IP Library › Granted Patent US 12,617,822
Granted Patent B2
US 12,617,822 · App. 18/046,354 · Granted May 5, 2026

Arc-based capsids and uses thereof

Inventors: Colin Malone (South Orange, NJ); Ian Peikon (Bethpage, NY); Zachary Gilbert (Brooklyn, NY); Andrey Pisarev (Brooklyn, NY); Adam Fraites (Boston, MA); Jessica Crisp (Phoenix, AZ)
Assignee: Aera Therapeutics, Inc.
C07K14/15A61K9/1658A61K38/00A61K39/39A61K48/0008C07K14/005C07K14/16C07K14/161C07K14/435C07K14/46C07K16/00C12N9/22C12N15/11C12N15/111C12N15/85C12N15/87C12N15/907A61K39/0011A61K2039/55555A61K2039/80C12N2310/12C12N2310/141C12N2310/20C12N2310/3519C12N2310/531C12N2320/32
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Quick Facts
Patent No.
US 12,617,822
App. No.
18/046,354
Granted
May 5, 2026
Kind
B2
Abstract

Disclosed herein, in certain embodiments, are recombinant Arc and endogenous Gag polypeptides, and methods of using recombinant Arc and endogenous Gag polypeptides.

Claims (11)

1 . A capsid comprising a recombinant endogenous Gag polypeptide and a heterologous cargo, wherein (a) the endogenous Gag polypeptide comprises (i) at least one capsid forming subunit from an endogenous Gag polypeptide that is not an Arc polypeptide and (ii) an RNA binding domain modified to bind to a heterologous cargo, and (b) the RNA binding domain is fused to the at least one capsid forming subunit through a linker.

2 . The capsid of claim 1 , wherein the cargo is an RNA and is bound to the RNA binding domain.

3 . The capsid of claim 1 , wherein the at least one capsid forming subunit is from an endogenous Gag polypeptide that is not an Arc polypeptide.

4 . The capsid of claim 1 , wherein the endogenous Gag polypeptide is a Paraneoplastic Ma antigen family polypeptide, a retrotransposon Gag-like (RTL) family polypeptide, or a SCAN domain family polypeptide.

5 . The capsid of claim 1 , wherein the linker is non-cleavable.

6 . The capsid of claim 5 , wherein the linker is selected from (EAAAK) n (SEQ ID NO: 70), or (EAAAR) n (SEQ ID NO: 71), where n is from 1 to 5, and up to 30 residues of glutamic acid-proline or lysine-proline repeats.

7 . The capsid of claim 5 , wherein the linker comprises (a) (GGGGS) n (SEQ ID NO: 72) or (GGGS) n (SEQ ID NO: 73), wherein n is 1 to 10, (b) KESGSVSSEQLAQFRSLD (SEQ ID NO: 74), or (c) EGKSSGSGSESKST (SEQ ID NO: 75).

8 . The capsid of claim 1 , wherein the linker is cleavable.

9 . The capsid of claim 8 , wherein the linker is cleaved by endogenous enzymes.

10 . The capsid of claim 1 , wherein the linker is fused to the C-terminus of the at least one capsid forming subunit.

11 . The capsid of claim 1 , wherein the linker is fused to the N-terminus of the at least one capsid forming subunit.

Assignments (2)
CHANGE OF NAME Recorded Jul 22, 2023
From: VNV NEWCO INC.
To: AERA THERAPEUTICS, INC.
Reel/Frame 064347/0692 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 13, 2023
From: MALONE, COLIN; PEIKON, IAN; GILBERT, ZACHARY; PISAREV, ANDREY; FRAITES, ADAM; CRISP, JESSICA
To: VNV NEWCO INC.
Reel/Frame 062376/0981 →
Continuity (4)
Continuation 17382102 · Jul 21, 2021
Continuation 17277119
Provisional Application 62733015 · Sep 18, 2018
Related Publication 20230312657A1 · Oct 5, 2023
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