Methods of treating ovarian cancer with hemp extract

1. A method for treating ovarian cancer comprising:

a. administering to a patient via intravaginal administration, a composition comprising a cannabis extract (CE) and, administering to said patient a chemotherapeutic agent;

b. wherein the chemotherapeutic agent is selected from the group consisting of: paclitaxel, altretamine, capecitabine, cyclosphosphamide, etoposide, gemcitabine, ifosfamide, itinotecan, doxorubicin, melphalan, pemetrexed, topotecan, binorelbine, carboplatin, cisplatin, docetaxel, and combinations thereof; and

c. wherein the composition comprising the cannabis extract comprises cannabidiol (CBD) at between 50% and 99% by weight of the CE, and has a pH of between 3.5 and 6.

2. The method of claim 1 wherein the method comprises a first step of determining chemoresistance of a cancerous tissue in a patient and a subsequent step of administering to the patient an effective amount of the cannabis extract and an effective amount of the chemotherapeutic agent upon confirmation of chemoresistance.

3. The method of claim 1 wherein the composition comprising the cannabis extract comprises:

a carrier, said carrier being between 1% and 90% by weight of the composition, and wherein the CE is between 1% and 99% by weight of the composition;

at least one additional cannabinoid selected from Δ-9-tetrahydrocannabinol (Δ 9 -THC, tetrahydrocannabinolic acid (THCA), tetrahydrocannabivarin (THCV), Δ-8-tetrahydrocannabinol (Δ 8 -THC), cannabichromene (CBC), cannabichromene acid (CBCA), cannabigerol (CBG), cannabigerol acid (CBGA), cannabidiolic acid (CBDA), cannabidivarin (CBDV), cannabinol (CBN), cannabicyclol (CBL), and combinations thereof; and

wherein the additional cannabinoid is between 0.1% and 10% by weight of the CE.

4. The method of claim 3 wherein the composition further comprises at least one terpene selected from the group consisting of: β-myrcene, β-caryophyllene, linalool, α-pinene, citral, D-limonene, eucalyptol, and combinations thereof.

5. The method of claim 3 wherein the composition further comprises at least one polyphenol selected from the group consisting of: a catechin, quercetin, cannflavin AB/C, rutin, chlorogenic acid, and combinations thereof.

6. The method of claim 3 wherein the composition further comprises at least one fatty acid selected from the group consisting of: an omega 3 acid, an omega 6 acid, an omega 9 acid, and combinations thereof.

7. The method of claim 3 wherein the composition further comprises at least one phytonutrient, wherein the phytonutrient is selected from the group consisting of: a tocopherol, a sterol, carotene, an aliphatic alcohol, a mineral, and combinations thereof.

8. The method of claim 1 wherein the CE is a broad spectrum hemp extract (BSHE) or a full spectrum hemp extract (FSHE) and wherein each of the BSHE or FSHE comprises 50% to 99% by weight of CBD and at least one other cannabinoid at a concentration of 0.1% to 10% wherein the at least one other cannabinoid is selected from the group consisting of: Δ 9 -THC, THCA, THCV, Δ 8 -THC, CBC, CBCA, CBG, CBGA, CBDA, CBDV, CBN, CBL, and combinations thereof.

9. The method of claim 8 wherein the CE comprises CBD at a concentration of between 60% and 99% and at least one other cannabinoid selected from the group consisting of: Δ 9 -THC, THCA, THCV, Δ 8 -THC, CBC, CBCA, CBG, CBGA, CBDA, CBDV, CBN, CBL, and combinations thereof and wherein the CE comprises a total concentration of cannabinoids of between 65% and 99% by weight.

10. The method of claim 1 wherein the composition comprises at least one additional compound selected from the group consisting of: a terpene, a polyphenol, an essential fatty acid, a phytonutrient, and combinations thereof; and wherein the at least one additional compound makes up between 0.1% and 50% of the total weight of the composition.

11. The method of claim 3 wherein the composition comprises an oil or a fat as a carrier.

12. The method of claim 3 wherein the chemotherapeutic drug and the CE are administered as one composition or as two different compositions.

13. The method of claim 1 wherein the ovarian cancer is a chemoresistant cancer.

14. The method of claim 1 , the composition further comprising:

i. at least one terpene selected from the group consisting of: β-myrcene, β-caryophyllene, linalool, α-pinene, citral, D-limonene, eucalyptol, and combinations thereof;

ii. at least one polyphenol selected from the group consisting of: catechins, quercetin, cannflavin A/B/C, rutin, chlorogenic acid, and combinations thereof;

iii. at least one essential fatty acid selected from the group consisting of: an omega 3, an omega 6, an omega 9, and combinations thereof; and

iv. at least one phytonutrient selected from the group consisting of: a tocopherol, a sterol, carotene, an aliphatic alcohol, a mineral, and combinations thereof.