Substituted pyrrolo[1,2-b]pyridazines as anthelmintics

1. A compound of Formula (I):

or a pharmaceutically acceptable salt or stereoisomer thereof,

wherein:

each independently is a single or double bond;

R 1 is H, halogen, CN, alkyl, alkyl-NH 2 , alkyl-NH(alkyl), alkyl-N(alkyl) 2 , alkyl-O(alkyl), alkenyl, alkynyl, C(O)alkyl, C(O)NH 2 , C(O)NH(alkyl), C(O)N(alkyl) 2 , C(O)O(alkyl), Si(alkyl) 3 , NR a R b , OH, O(alkyl), O(alkenyl), O(alkynyl), OSi(alkyl) 3 , O(aryl), SF 5 , S(O) p alkyl, S(O) p haloalkyl, cycloalkyl, cycloalkenyl, cycloalkoxy, heterocyclyl, aryl, or heteroaryl, wherein the alkyl, alkyl-NH 2 , alkyl-NH(alkyl), alkyl-N(alkyl) 2 , alkyl-O(alkyl), alkenyl, alkynyl, C(O)alkyl, C(O)NH 2 , C(O)NH(alkyl), C(O)N(alkyl) 2 , C(O)O(alkyl), Si(alkyl) 3 , O(alkyl), O(alkenyl), O(alkynyl), O(aryl), OSi(alkyl) 3 , S(O) p alkyl, S(O) p haloalkyl, cycloalkyl, cycloalkenyl, cycloalkoxy, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more independently selected substituents;

R 1′ is H, halogen, alkyl, or haloalkyl;

R 2 is H, halogen, CN, alkyl, alkyl-NH 2 , alkyl-NH(alkyl), alkyl-N(alkyl) 2 , alkyl-O(alkyl), alkenyl, alkynyl, C(O)alkyl, C(O)NH 2 , C(O)NH(alkyl), C(O)N(alkyl) 2 , C(O)O(alkyl), NR a R b , OH, O(alkyl), O(aryl), SF 5 , S(O) p alkyl, S(O) p haloalkyl, cycloalkyl, cycloalkenyl, cycloalkoxy, heterocyclyl, aryl, or heteroaryl, wherein the alkyl, alkyl-NH 2 , alkyl-NH(alkyl), alkyl-N(alkyl) 2 , alkyl-O(alkyl), alkenyl, alkynyl, C(O)alkyl, C(O)NH 2 , C(O)NH(alkyl), C(O)N(alkyl) 2 , C(O)O(alkyl), O(alkyl), O(aryl), S(O) p alkyl, S(O) p haloalkyl, cycloalkyl, cycloalkenyl, cycloalkoxy, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more independently selected substituents;

R 3 is H, halogen, CN, alkyl, alkyl-NH 2 , alkyl-NH(alkyl), alkyl-N(alkyl) 2 , alkyl-O(alkyl), alkenyl, alkynyl, C(O)alkyl, C(O)NH 2 , C(O)NH(alkyl), C(O)N(alkyl) 2 , C(O)O(alkyl), NR a R b , OH, O(alkyl), O(aryl), SF 5 , S(O) p alkyl, S(O) p haloalkyl, cycloalkyl, cycloalkenyl, cycloalkoxy, heterocyclyl, aryl, or heteroaryl, wherein the alkyl, alkyl-NH 2 , alkyl-NH(alkyl), alkyl-N(alkyl) 2 , alkyl-O(alkyl), alkenyl, alkynyl, C(O)alkyl, C(O)NH 2 , C(O)NH(alkyl), C(O)N(alkyl) 2 , C(O)O(alkyl), O(alkyl), O(aryl), S(O) p alkyl, S(O) p haloalkyl, cycloalkyl, cycloalkenyl, cycloalkoxy, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more independently selected substituents;

R 4 is H, alkyl, alkenyl, alkynyl, C(O)alkyl, C(O)NH 2 , C(O)NH(alkyl), C(O)N(alkyl) 2 , C(O)O(alkyl), NR a R b , SF 5 , S(O) p alkyl, cycloalkyl, cycloalkenyl, carbocyclyl-(spirocyclic carbocyclyl), carbocyclyl-(spirocyclic heterocyclyl), heterocyclyl, heterocyclyl-(spirocyclic carbocyclyl), heterocyclyl-(spirocyclic heterocyclyl), aryl, or 5- to 10-membered heteroaryl, wherein the alkyl, alkenyl, alkynyl, C(O)alkyl, C(O)NH 2 , C(O)NH(alkyl), C(O)N(alkyl) 2 , C(O)O(alkyl), S(O) p alkyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, or 5- to 10-membered heteroaryl is optionally substituted with one or more independently selected substituents;

each R a is independently H or alkyl, wherein each alkyl is optionally and independently substituted with one or more independently selected substituents;

each R b is independently H or alkyl, wherein each alkyl is optionally and independently substituted with one or more independently selected substituents; or

any R a and R b , taken together with the nitrogen atom to which they are attached, independently forms a 3- to 8-membered heterocyclyl;

wherein each 3- to 8-membered heterocyclyl independently contains 0, 1, 2, or 3 additional heteroatoms independently selected from the group consisting of N, O, Si, and S; and

wherein each 3- to 8-membered heterocyclyl is optionally and independently substituted with one or more independently selected substituents;

L is (L1), (L2), (L3), (L4), (L5), (L6), (L7), (L8), (L9), (L10), (L 11), (L12), (L13), (L14), (L15), (L16), or (L17):

—C(X)NR′-(L1), —NR′C(X)-(L2), —NR′C(X)NR′-(L3), —S(NR′)(O)CH 2 -(L4), —CH 2 S(NR′)(O)-(L5), —S(O) 2 NR′-(L6), —NR′S(O) 2 -(L7), —S(O) 2 CH 2 -(L8), —CH 2 S(O) 2 -(L9), —CH(CF 3 )NR′-(L10), —NR′CH(CF 3 )-(L11), —CH(CHF 2 )NR′-(L12), —NR′CH(CHF 2 )-(L13),

each X is independently NR′, O, or S;

R′ is H, alkyl, haloalkyl, cycloalkyl, aralkyl, or aryl, wherein the alkyl, haloalkyl, cycloalkyl, aralkyl, or aryl is optionally substituted with one or more independently selected substituents; or

two R′, together with the atoms to which they are attached, form a 2- to 4-membered carbon chain resulting in a 5- to 7-membered heterocyclyl;

Y 1 is C, CR 5 , or N;

Y 2 is CR 5 , —CR 5 R 5′ —, N, —NR′—, —O—, or —S—;

Y 3 is CR 5 , —CR 5 R 5′ —, N, —NR′—, —O—, or —S—;

Y 4 is CR 5 , —CR 5 R 5′ —, N, —NR′—, —O—, or —S—;

Y 5 is CR 5 , —CR 5 R 5′ —, N, —NR′—, —O—, or —S—;

Y 6 is C, CR 5 , or N;

W is absent, CR 6 , —CR 6 R 7 —, N, —NR′—, —O—, or —S(O) p —;

W 1 is CR 6 , —CR 6 R 7 —, N, —NR′—, —O—, or —S(O) p —;

Z is CR 7 , —CR 6 R 7 —, N, —NR′—, —O—, or —S(O) p —;

Q is CR 9 ;

each R 5 is independently H, halogen, CN, NO 2 , alkyl, alkyl-NH 2 , alkyl-NH(alkyl), alkyl-N(alkyl) 2 , alkyl-O(alkyl), alkenyl, alkynyl, C(O)alkyl, C(O)NH 2 , C(O)NH(alkyl), C(O)N(alkyl) 2 , C(O)O(alkyl), NR c R d , NHC(O)alkyl, OH, O(alkyl), OC(O)alkyl, SF 5 , S(O) p alkyl, S(O) p haloalkyl, cycloalkyl, cycloalkoxy, aryl, or heteroaryl, wherein each alkyl, alkyl-NH 2 , alkyl-NH(alkyl), alkyl-N(alkyl) 2 , alkyl-O(alkyl), alkenyl, alkynyl, C(O)alkyl, C(O)NH 2 , C(O)NH(alkyl), C(O)N(alkyl) 2 , C(O)O(alkyl), O(alkyl), S(O) p alkyl, S(O) p haloalkyl, cycloalkyl, cycloalkoxy, aryl, and heteroaryl is optionally and independently substituted with one or more independently selected substituents;

each R 5′ is independently H, halogen, CN, NO 2 , alkyl, alkyl-NH 2 , alkyl-NH(alkyl), alkyl-N(alkyl) 2 , alkyl-O(alkyl), alkenyl, alkynyl, C(O)alkyl, C(O)NH 2 , C(O)NH(alkyl), C(O)N(alkyl) 2 , C(O)O(alkyl), NR c R d , NHC(O)alkyl, OH, O(alkyl), OC(O)alkyl, SF 5 , S(O) p alkyl, S(O) p haloalkyl, cycloalkyl, cycloalkoxy, aryl, or heteroaryl, wherein each alkyl, alkyl-NH 2 , alkyl-NH(alkyl), alkyl-N(alkyl) 2 , alkyl-O(alkyl), alkenyl, alkynyl, C(O)alkyl, C(O)NH 2 , C(O)NH(alkyl), C(O)N(alkyl) 2 , C(O)O(alkyl), O(alkyl), S(O) p alkyl, S(O) p haloalkyl, cycloalkyl, cycloalkoxy, aryl, and heteroaryl is optionally and independently substituted with one or more independently selected substituents; or

any R 5 and R 5′ , taken together with the carbon atom to which they are attached, independently forms a 2- to 6-membered chain resulting in a 3- to 7-membered cyclyl;

wherein each 3- to 7-membered cyclyl optionally and independently contains 1 or 2 heteroatoms independently selected from the group consisting of N, O, Si, and S; and

wherein each 3- to 7-membered cyclyl is optionally and independently substituted with one or more independently selected substituents;

each R c is independently H or alkyl, wherein each alkyl is optionally and independently substituted with one or more independently selected substituents;

each R d is independently H or alkyl, wherein each alkyl is optionally and independently substituted with one or more independently selected substituents; or

any R c and R d , taken together with the nitrogen atom to which they are attached, independently forms a 3- to 8-membered heterocyclyl;

wherein each 3- to 8-membered heterocyclyl independently contains 0, 1, 2, or 3 additional heteroatoms independently selected from the group consisting of N, O, Si, and S; and

wherein each 3- to 8-membered heterocyclyl is optionally and independently substituted with one or more independently selected substituents;

each R 6 is independently H, halogen, alkyl, alkenyl, alkynyl, O(alkyl), cycloalkyl, or cycloalkoxy, wherein each alkyl, alkenyl, alkynyl, O(alkyl), cycloalkyl, and cycloalkoxy is optionally and independently substituted with one or more independently selected substituents;

each R 7 is independently H, halogen, alkyl, alkenyl, alkynyl, O(alkyl), cycloalkyl, or cycloalkoxy, wherein each alkyl, alkenyl, alkynyl, O(alkyl), cycloalkyl, and cycloalkoxy is optionally and independently substituted with one or more independently selected substituents; or

any R 6 and R 7 , taken together with the carbon atom to which they are attached, independently forms a 2- to 6-membered chain resulting in a 3- to 7-membered cyclyl;

wherein each 3- to 7-membered cyclyl optionally and independently contains 1 or 2 heteroatoms independently selected from the group consisting of N, O, Si, and S; and

wherein each 3- to 7-membered cyclyl is optionally and independently substituted with one or more independently selected substituents;

R 8 is H or C 1 -C 4 alkyl;

R 9 is H, halogen, alkyl, haloalkyl, alkenyl, alkynyl, or cycloalkyl;

each p is independently 0, 1, or 2; and

q is 0 or 1;

wherein each optional substituent is independently selected from the group consisting of halogen, CN, NO 2 , alkyl, haloalkyl, CH(NH), CH(NOH), C(NH)NH 2 , C(O)alkyl, C(O)haloalkyl, C(O)NH 2 , C(O)NH(alkyl), C(O)NH(haloalkyl), C(O)N(alkyl) 2 , C(O)N(haloalkyl) 2 , C(O)OH, C(O)O(alkyl), C(O)O(haloalkyl), C(O)OC(O)R, C(O)SR, C(S)NH 2 , Si(R) 3 , NH 2 , NH(alkyl), NHC(NH)NH 2 , NHNH 2 , NH(aryl), N(alkyl) 2 , N(aryl) 2 , OH, O(alkyl), O(haloalkyl), OC(O)NH 2 , OC(O)OR, OSi(R) 3 , OP(O)(OR)(OR), OS(O) 2 OH, O(aryl), ═O, P(R) 3 , P(O)R, P(O)(R) 2 , P(O)(OR)(OR), P(O)(OR)NH 2 , SH, SF 5 , S(alkyl), S(haloalkyl), S(O)alkyl, S(O)haloalkyl, S(O)(NH)R, S(O) 2 alkyl, S(O) 2 haloalkyl, S(O) 2 NH 2 , S(O) 2 OH, S(O) 2 O(alkyl), cycloalkyl, cycloalkenyl, heterocyclyl, aryl, and heteroaryl; and

each R is independently alkyl, haloalkyl, or aryl;

with the proviso that no more than three of Y 1 , Y 2 , Y 3 , Y 4 , Y 5 , and Y 6 are heteroatoms.

2. The compound according to claim 1 , wherein the compound is of Formula (IA):

or a pharmaceutically acceptable salt or stereoisomer thereof,

wherein:

each independently is a single or double bond;

R 1 is H, halogen, alkyl, alkyl-NH 2 , alkyl-NH(alkyl), alkyl-N(alkyl) 2 , alkyl-O(alkyl), alkenyl, alkynyl, NR a R b , O(alkyl), O(alkenyl), O(alkynyl), cycloalkyl, cycloalkenyl, or heterocyclyl, wherein the alkyl, alkyl-NH 2 , alkyl-NH(alkyl), alkyl-N(alkyl) 2 , alkyl-O(alkyl), alkenyl, alkynyl, O(alkyl), O(alkenyl), O(alkynyl), cycloalkyl, cycloalkenyl, or heterocyclyl is optionally substituted with one or more independently selected substituents;

R 2 is H, halogen, CN, alkyl, alkyl-NH 2 , alkyl-NH(alkyl), alkyl-N(alkyl) 2 , alkyl-O(alkyl), alkenyl, alkynyl, OH, or O(alkyl), wherein the alkyl, alkyl-NH 2 , alkyl-NH(alkyl), alkyl-N(alkyl) 2 , alkyl-O(alkyl), alkenyl, alkynyl, or O(alkyl) is optionally substituted with one or more independently selected substituents;

R 3 is H, halogen, CN, alkyl, alkyl-NH 2 , alkyl-NH(alkyl), alkyl-N(alkyl) 2 , alkyl-O(alkyl), alkenyl, alkynyl, OH, or O(alkyl), wherein the alkyl, alkyl-NH 2 , alkyl-NH(alkyl), alkyl-N(alkyl) 2 , alkyl-O(alkyl), alkenyl, alkynyl, or O(alkyl) is optionally substituted with one or more independently selected substituents;

R 4 is cycloalkyl, cycloalkenyl, heterocyclyl, phenyl, or 5- or 6-membered heteroaryl, wherein the cycloalkyl, cycloalkenyl, heterocyclyl, phenyl, or 5- or 6-membered heteroaryl is optionally substituted with one or more independently selected substituents;

L is (L1), (L2), (L6), (L7), (L16), or (17):

—C(X)NR′-(L1), —NR′C(X)-(L2), —S(O) 2 NR′-(L6), —NR′S(O) 2 -(L7),

R′ is H, alkyl, haloalkyl, or aralkyl, wherein the alkyl, haloalkyl, or aralkyl is optionally substituted with one or more independently selected substituents; or

Y 1 is C or N;

Y 2 is CR 5 or N;

Y 3 is CR 5 or N;

Y 4 is CR 5 or N;

Y 5 is CR 5 or N;

Y 6 is C or N;

W is absent, CR 6 , or —CR 6 R 7 —;

W 1 is CR 6 or —CR 6 R 7 —;

Z is CR 7 , —CR 6 R 7 —, or —O—;

each R 5 is independently H, halogen, CN, alkyl, alkenyl, alkynyl, or O(alkyl), wherein each alkyl, alkenyl, alkynyl, and O(alkyl) is optionally and independently substituted with one or more independently selected substituents;

each R 5 is independently H, halogen, CN, alkyl, alkenyl, alkynyl, or O(alkyl), wherein each alkyl, alkenyl, alkynyl, and O(alkyl) is optionally and independently substituted with one or more independently selected substituents;

each R 6 is independently H, halogen, alkyl, alkenyl, alkynyl, or O(alkyl), wherein each alkyl, alkenyl, alkynyl, and O(alkyl) is optionally and independently substituted with one or more independently selected substituents;

each R 7 is independently H, halogen, alkyl, alkenyl, alkynyl, or O(alkyl), wherein each alkyl, alkenyl, alkynyl, and O(alkyl) is optionally and independently substituted with one or more independently selected substituents; or

any R 6 and R 7 , taken together with the carbon atom to which they are attached, independently forms a 2- to 6-membered chain resulting in a 3- to 7-membered cyclyl;

wherein each 3- to 7-membered cyclyl optionally and independently contains 1 or 2 heteroatoms independently selected from the group consisting of N, O, Si, and S; and

wherein each 3- to 7-membered cyclyl is optionally and independently substituted with one or more independently selected substituents; and

R 9 is H, halogen, alkyl, or haloalkyl;

wherein each optional substituent is independently selected from the group consisting of halogen, CN, alkyl, haloalkyl, acyl, C(O)alkyl, C(O)haloalkyl, C(O)NH 2 , C(O)NH(alkyl), C(O)NH(haloalkyl), C(O)N(alkyl) 2 , C(O)N(haloalkyl) 2 , C(O)OH, C(O)O(alkyl), C(O)O(haloalkyl), C(S)NH 2 , Si(R) 3 , NH 2 , NH(alkyl), N(alkyl) 2 , OH, O(alkyl), O(haloalkyl), O(acyl), OSi(R) 3 , OS(O) 2 OH, SH, SF 5 , S(alkyl), S(haloalkyl), S(O)alkyl, S(O) 2 alkyl, S(O) 2 haloalkyl, S(O) 2 O(alkyl), and cycloalkyl.

3. The compound according to claim 1 , or a pharmaceutically acceptable salt or stereoisomer thereof, wherein L is (L1) or (L2):

—C(X)NR′-(L1) or —NR′C(X)-(L2).

4. The compound according to claim 1 , or a pharmaceutically acceptable salt or stereoisomer thereof, wherein each X is independently O or S.

5. The compound according to claim 1 , or a pharmaceutically acceptable salt or stereoisomer thereof, wherein:

W is —CR 6 R 7 —;

W 1 is —CR 6 R 7 —; and

Z is —O—.

6. The compound according to claim 1 , or a stereoisomer thereof, wherein the compound, or stereoisomer thereof, is of Formula (IA-1):

or a pharmaceutically acceptable salt thereof,

wherein:

 is Ring System A, Ring System B, Ring System C, Ring System D, Ring System E, Ring System F, Ring System G, Ring System H, Ring System I, Ring System J, Ring System K, Ring System L, Ring System M, Ring System N, Ring System O, Ring System P, Ring System Q, Ring System R, Ring System S, Ring System T, Ring System U, Ring System V, Ring System W, Ring System X, Ring System Y, Ring System Z, Ring System AA, Ring System AB, Ring System AC, Ring System AD, or Ring System AE:

7. The compound according to claim 1 , wherein the compound is of Formula (Ie):

or a pharmaceutically acceptable salt or stereoisomer thereof,

wherein:

is a single or double bond;

W is absent or —CR 6 R 7 —;

each R 10 is independently halogen, CN, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C(O)C 1 -C 6 alkyl, C(O)C 1 -C 6 haloalkyl, C(O)NH 2 , C(O)NH(C 1 -C 6 alkyl), C(O)NH(C 1 -C 6 haloalkyl), C(O)N(C 1 -C 6 alkyl) 2 , C(O)N(C 1 -C 6 haloalkyl) 2 , C(O)O(C 1 -C 6 alkyl), C(O)O(C 1 -C 6 haloalkyl), NH 2 , NH(C 1 -C 6 alkyl), N(C 1 -C 6 alkyl) 2 , OH, O(C 1 -C 4 alkyl), O(C 1 -C 4 haloalkyl), O(phenyl), SF 5 , S(C 1 -C 6 alkyl), S(C 1 -C 6 haloalkyl), S(O)C 1 -C 6 alkyl, S(O)C 1 -C 6 haloalkyl, S(O) 2 C 1 -C 6 alkyl, S(O) 2 C 1 -C 6 haloalkyl, C 3 -C 5 cycloalkyl, 3- to 7-membered heterocyclyl, phenyl, or 5- or 6-membered heteroaryl, wherein each 3- to 7-membered heterocyclyl independently contains 1, 2, or 3 heteroatoms independently selected from the group consisting of N, O, Si, and S; and

m is 0, 1, 2, 3, 4, or 5.

8. The compound according to claim 7 , or a pharmaceutically acceptable salt or stereoisomer thereof, wherein:

each R 10 is independently halogen; and

m is 2 or 3.

9. The compound according to claim 7 , or a pharmaceutically acceptable salt or stereoisomer thereof, wherein:

R 1 is C 1 -C 4 alkyl or NR a R b ;

R 2 is H, halogen, CN, C 1 -C 3 alkyl or C 1 -C 3 haloalkyl;

R 3 is H, halogen, CN, C 1 -C 3 alkyl or C 1 -C 3 haloalkyl;

R′ is H,

W is —CH 2 —;

W 1 is —CH 2 —;

Z is —O—;

each R 10 is independently F or Cl; and

m is 2 or 3.

10. The compound according to claim 9 , or a pharmaceutically acceptable salt or stereoisomer thereof, wherein:

R 1 is C 1 -C 4 alkyl or NR a R b ;

R 2 is H;

R 3 is halogen or C 1 -C 3 alkyl; and

 is:

11. The compound according to claim 10 , or a pharmaceutically acceptable salt or stereoisomer thereof, wherein R 1 is CH(CH 3 ) 2 , C(CH 3 ) 3 , N(CH 3 ) 2 , or azetidin-1-yl, wherein the azetidin-1-yl is optionally substituted with one or more substituents independently selected from the group consisting of F and CH 3 .

12. The compound according to claim 11 , or a pharmaceutically acceptable salt or stereoisomer thereof, wherein R 3 is Cl or CH 3 .

13. The compound according to claim 12 , or a pharmaceutically acceptable salt or stereoisomer thereof, wherein R 1 is CH(CH 3 ) 2 , C(CH 3 ) 3 , or N(CH 3 ) 2 .

14. The compound according to claim 13 , or a pharmaceutically acceptable salt or stereoisomer thereof, wherein:

Y 2 is CR 5 ;

Y 3 is CR 5 ;

Y 4 is CR 5 ;

Y 5 is CR 5 ; and

each R 5 is independently H.

15. The compound according to claim 9 , or a pharmaceutically acceptable salt or stereoisomer thereof, wherein:

(a) Y 2 is N;

Y 3 is CR 5 ;

Y 4 is CR 5 ; and

Y 5 is CR 5 ; or

(b) Y 2 is CR 5 ;

Y 3 is N;

Y 4 is CR 5 ; and

Y 5 is CR 5 ; or

(c) Y 2 is CR 5 ;

Y 3 is CR 5 ;

Y 4 is N; and

Y 5 is CR 5 ; or

(d) Y 2 is CR 5 ;

Y 3 is CR 5 ;

Y 4 is CR 5 ; and

Y 5 is N; or

(e) Y 2 is CR 5 ;

Y 3 is N;

Y 4 is N; and

Y 5 is CR 5 ; or

(f) Y 2 is CR 5 ;

Y 3 is N;

Y 4 is CR 5 ; and

Y 5 is N; or

(g) Y 2 is CR 5 ;

Y 3 is CR 5 ;

Y 4 is N; and

Y 5 is N; or

(h) Y 2 is N;

Y 3 is N;

Y 4 is CR 5 ; and

Y 5 is CR 5 ; or

(i) Y 2 is N;

Y 3 is CR 5 ;

Y 4 is N; and

Y 5 is CR 5 .

16. The compound according to claim 9 , or a pharmaceutically acceptable salt or stereoisomer thereof, wherein:

Y 2 is CR 5 ;

Y 3 is CR 5 ;

Y 4 is CR 5 ; and

Y 5 is CR 5 .

17. A veterinary composition comprising a pharmaceutically acceptable carrier and the compound according to claim 1 , or a pharmaceutically acceptable salt or stereoisomer thereof.

18. The veterinary composition according to claim 17 , wherein the veterinary composition further comprises one or more additional active agents.

19. A compound or a stereoisomer thereof, wherein the compound, or stereoisomer thereof, is selected from the group consisting of:

or a pharmaceutically acceptable salt thereof.

20. The compound according to claim 19 , wherein the compound is:

21. The compound according to claim 19 , wherein the compound is:

22. The compound according to claim 19 , wherein the compound is:

23. The compound according to claim 19 , wherein the compound is:

24. The compound according to claim 19 , wherein the compound is:

25. The compound according to claim 19 , wherein the compound is:

26. The compound according to claim 19 , wherein the compound is:

27. The compound according to claim 19 , wherein the compound is:

28. The compound according to claim 19 , wherein the compound is:

29. The compound according to claim 19 , wherein the compound is:

30. A veterinary composition comprising a pharmaceutically acceptable carrier and the compound according to claim 19 , or a pharmaceutically acceptable salt or stereoisomer thereof.

31. The veterinary composition according to claim 30 , wherein the veterinary composition further comprises one or more additional active agents.