Vessel modification using heat therapy
A system includes an intravascular medical device and a therapeutic medical device. The intravascular medical device includes a heat therapy assembly and an elongated member coupled to the heat therapy assembly. The heat therapy assembly is configured to contract a wall of a vessel and deliver energy to the wall of the contracted vessel to heat the wall of the vessel. The therapeutic medical device is communicatively coupled to the heat therapy assembly and configured to control the heat therapy assembly to deliver the energy to ablate smooth muscle cells of the wall of the vessel and substantially denature one or more structural proteins of the wall of the vessel.
1 . A system, comprising:
an intravascular medical device comprising:
a heat therapy assembly configured to:
contract a wall of a vessel adjacent to a treatment site to a reduced diameter; and
deliver energy to the wall of the contracted vessel to heat the wall of the vessel; and
an elongated member coupled to the heat therapy assembly; and
a therapeutic medical device communicatively coupled to the heat therapy assembly and configured to control the heat therapy assembly to deliver the energy to:
ablate smooth muscle cells of the wall of the vessel; and
substantially denature one or more structural proteins of the wall of the vessel,
wherein, to contract the wall of the vessel, the heat therapy assembly comprises a contraction assembly configured to isolate a constriction volume of the vessel adjacent to the treatment site and create a vacuum in the constriction volume.
2 . The system of claim 1 , wherein the contraction assembly comprises:
a proximal balloon configured to inflate to seal a proximal end of the constriction volume; and
a distal balloon configured to inflate to seal a distal end of the constriction volume.
3 . The system of claim 1 , wherein the heat therapy assembly includes one or more openings configured to remove a fluid from the constriction volume to create the vacuum.
4 . The system of claim 1 ,
wherein the heat therapy assembly comprises a balloon comprising a cavity configured to contain a thermal medium, the balloon defining one or more surfaces configured to contact the wall of the vessel, and
wherein the one or more surfaces are configured to deliver the energy from the thermal medium to the wall of the vessel.
5 . The system of claim 1 , wherein the heat therapy assembly comprises one or more therapeutic elements configured to deliver the energy to the wall of the vessel.
6 . The system of claim 1 ,
wherein the heat therapy assembly comprises an expansion device,
wherein the expansion device is configured to radially expand to expand the wall of the vessel, and
wherein the therapeutic medical device is configured to control the expansion device to expand the wall of the vessel to a particular diameter.
7 . The system of claim 1 ,
wherein the one or more structural proteins comprise elastin and collagen, and
wherein after substantial denaturation, the one or more structural proteins cross-link to form a scaffold.
8 . The system of claim 7 , wherein greater than about 50% of structural proteins at the treatment site are denatured.
9 . The system of claim 1 , wherein, to ablate the smooth muscle cells and substantially denature the one or more structural proteins, the therapeutic medical device is configured to control the heat therapy assembly to maintain a temperature of the smooth muscle cells within a target temperature range.
10 . The system of claim 9 ,
wherein the target temperature range is defined by a lower temperature threshold value associated with death of the smooth muscle cells and denaturation of the one or more structural proteins, and
wherein the lower temperature threshold value is greater than about 60° C.
11 . The system of claim 9 ,
wherein the target temperature range is defined by an upper temperature threshold value associated with bubble formation of one or more fluids in the wall of the vessel, and
wherein the upper temperature threshold is less than about 100° C.
12 . The system of claim 1 , wherein the contraction assembly comprises a vacuum balloon configured to deflate in the constriction volume to create the vacuum.
13 . The system of claim 12 , wherein the vacuum balloon is configured to deliver the energy to the wall of the vessel.
14 . A method comprising:
contracting a wall of a vessel adjacent to a treatment site to a reduced diameter, wherein the wall of the vessel includes smooth muscle cells and one or more structural proteins; and
heating the wall of the contracted vessel to ablate the smooth muscle cells and substantially denature the one or more structural proteins,
wherein contracting the wall of the vessel comprises sealing a constriction volume of the vessel adjacent to the treatment site and creating a vacuum in the constriction volume.
15 . The method of claim 14 ,
wherein the one or more structural proteins comprise elastin and collagen, and
wherein after substantial denaturation, the one or more structural proteins cross-link to form a scaffold.
16 . The method of claim 14 , wherein sealing the constriction volume comprises:
inflating a proximal balloon to seal a proximal end of the constriction volume; and
inflating a distal balloon to seal a distal end of the constriction volume.
17 . The method of claim 14 , wherein contracting the wall of the vessel further comprises removing a fluid from the constriction volume to create the vacuum.
18 . The system of claim 5 ,
wherein the one or more therapeutic elements comprise at least one thermoelectric element,
wherein the therapeutic medical device is configured to control an electrical current to at least one thermoelectric element, and
wherein at least one thermoelectric element comprises a plurality of Peltier devices.
19 . The method of claim 14 , wherein, to ablate the smooth muscle cells and substantially denature the one or more structural proteins, the method includes controlling a heat therapy assembly to maintain a temperature of the smooth muscle cells within a target temperature range.
20 . The method of claim 19 ,
wherein the target temperature range is defined by a lower temperature threshold value associated with death of the smooth muscle cells and denaturation of the one or more structural proteins, and
wherein the lower temperature threshold value is greater than about 60° C.
21 . The method of claim 19 ,
wherein the target temperature range is defined by an upper temperature threshold value associated with boiling of one or more fluids in the wall of the vessel, and
wherein the upper temperature threshold is less than about 100° C.
22 . The method of claim 14 ,
wherein creating the vacuum comprises deflating a vacuum balloon in the constriction volume.
23 . The method of claim 22 , wherein delivering energy to the wall of the vessel comprises delivering energy to the wall of the vessel from the vacuum balloon.