IP Library › Patent Application 18061354
Patent Application
App. No. 18/061,354

SYNTHESIS AND NOVEL SALT FORMS OF (R)-5-((E)-2-PYRROLIDIN-3-YLVINYL)PYRIMIDINE

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Patent No.
US None
App. No.
18/061,354
Abstract

The present invention relates to the stereospecific synthesis of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine, its salt forms, and novel polymorphic forms of these salts.

Claims (2)

1 . A product (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine mono-citrate formed by a method through the intermediacy of tert-butyl(R)-3-vinylpyrrolidine-1-carboxylate.

2 . The product of claim 1 , wherein the tert-butyl(R)-3-vinylpyrrolidine-1-carboxylate is formed through the intermediacy of one or more of diethyl (R)-2-(1-(tert-butoxycarbonyl)pyrrolidin-3-yl)malonate, (R)-2-(1-(tert-butoxycarbonyl)pyrrolidin-3-yl)malonic acid, tert-butyl(R)-3-(2-hydroxyethyl)pyrrolidine-1-carboxylate, and tert-butyl(R)-3-(2-iodoethyl)pyrrolidine-1-carboxylate.

Assignments (5)
CORRECTIVE ASSIGNMENT TO CORRECT THE TYPOGRAPHICAL ERROR IN 2ND INVENTOR'S FIRST NAME FROM BALWINGER SINGH BHATTI TO BALWINDER SINGH BHATTI PREVIOUSLY RECORDED ON REEL 062066 FRAME 0148. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Feb 10, 2023
From: AKIREDDY, SRINIVASA RAO; BHATTI, BALWINDER SINGH; CUTHBERTSON, TIMOTHY J.; DULL, GARY MAURICE; MILLER, CRAIG HARRISON; MITCHENER, JOSEPH PIKE, JR.; MUNOZ, JULIO A.; OTTEN, PIETER ALBERT
To: TARGACEPT, INC.
Reel/Frame 062699/0981 →
RELEASE OF SECURITY INTEREST Recorded Feb 3, 2023
From: ORBIMED ROYALTY & CREDIT OPPORTUNITIES III, LP
To: OYSTER POINT PHARMA INC.
Reel/Frame 062582/0873 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 5, 2022
From: CATALYST BIOSCIENCES, INC.
To: OYSTER POINT PHARMA, INC.
Reel/Frame 062065/0807 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 5, 2022
From: AKIREDDY, SRINIVASA RAO; BHATTI, BALWINGER SINGH; CUTHBERTSON, TIMOTHY J.; DULL, GARY MAURICE; MILLER, CRAIG HARRISON; MITCHENER, JOSEPH PIKE, JR.; MUNOZ, JULIO A.; OTTEN, PIETER ALBERT
To: TARGACEPT, INC.
Reel/Frame 062066/0148 →
CHANGE OF NAME Recorded Dec 5, 2022
From: TARGACEPT, INC.
To: CATALYST BIOSCIENCES, INC.
Reel/Frame 062066/0201 →