IP Library › Granted Patent US 12,077,725
Granted Patent B2
US 12,077,725 · App. 18/064,565 · Granted Sep 3, 2024

Ionizable cationic lipids

Inventors: Daryl C. Drummond (Lincoln, MA); Dmitri B. Kirpotin (San Francisco, CA); Mark E. Hayes (Mill Valley, CA)
Assignee: Akagera Medicines, Inc.
C11C3/003C07D317/28C07F9/091
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Quick Facts
Patent No.
US 12,077,725
App. No.
18/064,565
Granted
Sep 3, 2024
Kind
B2
Abstract

The present disclosure provides compounds useful as ionizable cationic lipids. The ionizable cationic lipids are useful for preparing lipid nanoparticles for the delivery of therapeutic nucleic acids to cells. Cationic ionizable lipids were engineered with improved stability to oxidative degradation while in storage.

Claims (20)

1. A compound selected from the group consisting of AKG-UO-1, AKG-UO-1A, AKG-UO-1B, AKG-UO-2, AKG-UO-4, AKG-UO-4A, AKG-UO-5, AKG-UO-6, AKG-UO-7, AKG-UO-8, AKG-UO-9, AKG-UO-10, Compound 17, Compound 18, Compound 19, Compound 23, Compound 24, and Compound 25:

2. The compound of claim 1 , wherein the compound is selected from the group consisting of AKG-UO-1, AKG-UO-2, AKG-UO-4, AKG-UO-5, Compound 17, Compound 18, Compound 19, Compound 23, Compound 24, and Compound 25:

3. The compound of claim 1 , wherein the compound is AKG-UO-1:

4. The compound of claim 1 , wherein the compound is AKG-UO-2:

5. The compound of claim 1 , wherein the compound is AKG-UO-4:

6. The compound of claim 1 , wherein the compound is AKG-UO-5:

7. The compound of claim 1 , wherein the compound is Compound 17:

8. The compound of claim 1 , wherein the compound is Compound 18:

9. The compound of claim 1 , wherein the compound is Compound 19:

10. The compound of claim 1 , wherein the compound is Compound 23:

11. The compound of claim 1 , wherein the compound is Compound 24:

12. The compound of claim 1 , wherein the compound is Compound 25:

13. The compound of claim 1 , wherein the compound is AKG-UO-1A:

14. The compound of claim 1 , wherein the compound is AKG-UO-1B:

15. The compound of claim 1 , wherein the compound is AKG-UO-4A:

16. The compound of claim 1 , wherein the compound is AKG-UO-6:

17. The compound of claim 1 , wherein the compound is AKG-UO-7:

18. The compound of claim 1 , wherein the compound is AKG-UO-8:

19. The compound of claim 1 , wherein the compound is AKG-UO-9:

20. The compound of claim 1 , wherein the compound is AKG-UO-10:

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 19, 2024
From: DRUMMOND, DARYL C.; KIRPOTIN, DMITRI B.; HAYES, MARK E.
To: AKAGERA MEDICINES, INC.
Reel/Frame 066819/0702 →
Continuity (3)
Continuation 17456567 · Nov 24, 2021
Provisional Application 63118534 · Nov 25, 2020
Related Publication 20230126953A1 · Apr 27, 2023
Cited By (4)
US 12,331,264 US 12,559,450 US 12,605,464 US 12,606,773