Modulating angiogenesis by proteomimetics of vascular endothelial growth factor
Provided herein are novel VEGF mimics, pharmaceutical compositions thereof, and methods of their use in increasing or reducing angiogenesis.
1. A sulfono-γ-AA peptide according to Formula 1 and having the structure:
2. A method of reducing cell migration in a population of cells, the method comprising administering to the cells the sulfono-γ-AA peptide of claim 1 .
3. A method of reducing capillary tube formation in a population of cells, the method comprising administering to the cells the sulfono-γ-AA peptide of claim 1 .
4. A pharmaceutical composition comprising:
the sulfono-γ-AA peptide of claim 1 ; and
a pharmaceutically acceptable carrier.
5. The pharmaceutical composition of claim 4 , further comprising at least one of:
a sulfono-γ-AA peptide according to Formula 3 and having the structure:
and
a sulfono-γ-AA peptide according to Formula 2 and having the structure:
6. A method of reducing angiogenesis in a subject in need thereof comprising administering to the subject a therapeutically acceptable amount of the pharmaceutical composition of claim 4 .
7. The method of claim 6 , wherein the subject in need thereof has, or is suspected of having, a cancer or retinopathy.
8. A sulfono-γ-AA peptide according to Formula 3 and having the structure:
9. A method of reducing cell migration in a population of cells, the method comprising administering to the cells the sulfono-γ-AA peptide of claim 8 .
10. A method of reducing capillary tube formation in a population of cells, the method comprising administering to the cells the sulfono-γ-AA peptide of claim 8 .
11. A pharmaceutical composition comprising:
the sulfono-γ-AA peptide of claim 8 ; and
a pharmaceutically acceptable carrier.
12. A method of reducing angiogenesis in a subject in need thereof comprising administering to the subject a therapeutically acceptable amount of the pharmaceutical composition of claim 11 .
13. The method of claim 12 , wherein the subject in need thereof has, or is suspected of having, a cancer or retinopathy.
14. A sulfono-γ-AA peptide according to Formula 2 and having the structure:
15. A method of increasing cell migration in a population of cells, the method comprising administering to the cells the sulfono-γ-AA peptide of claim 14 .
16. A method of increasing capillary tube formation in a population of cells, the method comprising administering to the cells the sulfono-γ-AA peptide of claim 14 .
17. A pharmaceutical composition comprising:
the sulfono-γ-AA peptide of claim 14 ; and
a pharmaceutically acceptable carrier.
18. A method of increasing angiogenesis in a subject in need thereof comprising administering to the subject a therapeutically acceptable amount of the pharmaceutical composition of claim 17 .
19. The method of claim 18 , wherein the subject in need thereof has, or is suspected of having, ischemic heart disease.
20. The method of claim 18 , wherein the subject in need thereof has a wound or damage to an organ.