Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2”). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.
1. A compound selected from:
Ex. 170
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(+/−) Ex. 389
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(+/−) Ex. 395
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, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
2. The compound of claim 1 , which is:
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
3. The compound of claim 1 , which is:
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
4. The compound of claim 1 , which is:
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
5. The compound of claim 1 , which is:
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
6. The compound of claim 1 , which is:
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
7. The compound of claim 1 , which is:
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
8. The compound of claim 1 , which is:
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
9. The compound of claim 1 , which is:
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
10. The compound of claim 1 , which is:
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
11. The compound of claim 1 , which is:
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
12. The compound of claim 1 , which is:
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
13. The compound of claim 1 , which is:
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
14. The compound of claim 1 , which is:
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
15. The compound of claim 1 , which is:
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
16. A pharmaceutical composition comprising a compound selected from:
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Ex. 207
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Ex. 215
Ex. 216
Ex. 241
Ex. 242
Ex. 252
Ex. 272
Ex. 273
Ex. 286
Ex. 301
Ex. 330
Ex. 360
Ex. 366
(+/−) Ex. 389
(+/−) Ex. 394
(+/−) Ex. 395
Ex. 397
Ex. 407
Ex. 413
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer, and a pharmaceutically acceptable excipient.
17. The pharmaceutical composition of claim 16 , wherein the compound is
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
18. The pharmaceutical composition of claim 16 , wherein the compound is
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
19. The pharmaceutical composition of claim 16 , wherein the compound is
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
20. The pharmaceutical composition of claim 16 , wherein the compound is
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
21. The pharmaceutical composition of claim 16 , wherein the compound is
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
22. The pharmaceutical composition of claim 16 , wherein the compound is
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
23. The pharmaceutical composition of claim 16 , wherein the compound is
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
24. The pharmaceutical composition of claim 16 , wherein the compound is
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
25. The pharmaceutical composition of claim 16 , wherein the compound is
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
26. The pharmaceutical composition of claim 16 , wherein the compound is
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
27. The pharmaceutical composition of claim 16 , wherein the compound is
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
28. The pharmaceutical composition of claim 16 , wherein the compound is
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
29. The pharmaceutical composition of claim 16 , wherein the compound is
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.
30. The pharmaceutical composition of claim 16 , wherein the compound is
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.