INTEGRATED PACKAGE FOR ADMINISTRATION OF LYOPHILIZED MEDICINES
An auto-disable prefillable integrated package apparatus includes a first chamber, a second chamber, a connection configured to form a communicable channel between the first chamber and the second chamber, a frangible membrane configured to form a rupturable barrier within the connector that separates the first chamber and the second chamber, and a hub configured to be communicably coupled to the second chamber.
1 . An auto-disable prefillable integrated package apparatus, comprising:
a first chamber;
a second chamber;
a connection configured to form a communicable channel between the first chamber and the second chamber;
a frangible membrane configured to form a rupturable barrier within the connector that separates the first chamber and the second chamber; and
a hub configured to be communicably coupled to the second chamber.
2 . The auto-disable prefillable integrated package apparatus of claim 1 , wherein the second chamber comprises a compressible inner volume.
3 . The auto-disable prefillable integrated package apparatus of claim 1 , further comprising a valve configured to prevent fluid flow from the second chamber into the first chamber via the connector.
4 . The auto-disable prefillable integrated package apparatus of claim 1 , further comprising a needle assembly configured to be communicatively coupled to the hub.
5 . The auto-disable prefillable integrated package apparatus of claim 1 , further comprising a bonded periphery.
6 . The auto-disable prefillable integrated package apparatus of claim 1 , wherein the frangible membrane is configured to rupture when a mechanical force above a rupture threshold is applied by a user to the connector.
7 . The auto-disable prefillable integrated package apparatus of claim 1 , wherein the hub comprises a port.
8 . The auto-disable prefillable integrated package apparatus of claim 3 , wherein the valve comprises a disc valve.
9 . The auto-disable prefillable integrated package apparatus of claim 1 , wherein the frangible membrane comprises a polymer compound.
10 . A multi-chamber integrated package apparatus, comprising:
a first chamber;
a second chamber;
a third chamber;
a first connector configured to form a communicable channel between the first chamber and the third chamber;
a second connector configured to form a communicable channel between the second chamber and the third chamber;
a first frangible membrane configured to form a rupturable barrier within the first connector separating the first chamber and the third chamber;
a second frangible membrane configured to form a rupturable barrier within the second connector separating the second chamber and the third chamber; and
a hub configured to be communicatively coupled to the third chamber.
11 . The multi-chamber integrated package apparatus of claim 10 , wherein the third chamber is configured to have a compressible inner volume.
12 . The multi-chamber integrated package apparatus of claim 10 , wherein the third chamber is configured to contain a lyophilized drug product.
13 . The multi-chamber integrated package apparatus of claim 12 , wherein the first chamber is configured to contain a reconstitution solution.
14 . The multi-chamber integrated package apparatus of claim 12 , wherein the second chamber is configured to contain a reconstitution solution.
15 . The multi-chamber integrated package apparatus of claim 10 , further comprising a needle assembly configured to be communicably coupled to the hub.
16 . The multi-chamber integrated package apparatus of claim 10 , wherein the first frangible membrane and the second frangible membrane are configured to rupture when a mechanical force above a rupture threshold is applied by a user to the corresponding one of the first connector and the second connector.
17 . A syringe-type integrated package apparatus, comprising:
a cylindrical body having a first chamber and a second chamber separated by a frangible membrane;
a plunger assembly;
a hub communicably coupled to the second chamber; and
a needle assembly configured to be communicably coupled to the hub.
18 . The syringe-type integrated package apparatus of claim 17 , wherein the frangible membrane is configured to rupture when a mechanical force above a rupture threshold is applied by a user to the plunger assembly in a direction that presses the plunger assembly into the cylindrical body.
19 . The syringe-type integrated package apparatus of claim 17 , wherein the first chamber is configured to contain a reconstitution solution.
20 . The syringe-type integrated package apparatus of claim 17 , wherein the second chamber is configured to contain a lyophilized drug product.