Granted Patent
B2
US 12,226,550 · App. 18/086,506 · Granted Feb 18, 2025
Method of manufacturing a bioimplant
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Abstract
Provided is a bioimplant which is capable to inhibit the biofilm formation over a long period of time after an operation. The bioimplant of the present invention comprises a base material of metal, ceramic, or plastic and a thermal spraying film of a calcium phosphate-based material formed at least partially thereon and the silver concentration in the thermal-spray film is 0.05 wt % to 3.00 wt %.
Claims (14)
1. A method of manufacturing a bioimplant, comprising: providing a base material of the bioimplant;
forming a coating comprising a calcium phosphate-based material and a silver material on at least a part of a surface of the base material;
after forming the coating, heating the coating at a predetermined temperature under a predetermined pressure to form oxyapatite in the coating; and
immersing the coating in purified water to convert oxyapatite present in the coating to hydroxyapatite, wherein the immersing results in fine crystals of the hydroxyapatite being formed on a surface of the coating, wherein a size of the fine crystals of hydroxyapatite is in a range of 0.01 μm to 2.00 μm in length, thickness or width, and
wherein a temperature of the purified water is in a range of 60 to 100 degrees Celsius.
2. The method according to claim 1 , wherein said calcium phosphate-based material is a compound or a mixture of two or more compounds selected from the group consisting of hydroxyapatite, alpha-tricalcium phosphate, beta-tricalcium phosphate, and tetracalcium phosphate.
3. The method according to claim 1 , wherein the base material comprises a metal.
4. The method according to claim 1 , wherein the base material comprises ceramic.
5. The method according to claim 1 , wherein the base material comprises a plastic.
6. The method according to claim 1 , wherein:
the heating is performed at a temperature range of 550 to 850 degrees Celsius for a period of time in the range of 1 to 5 hours; and
the immersing is performed for a period of time in the range of 10 to 60 μminutes.
7. The method according to claim 1 , wherein the resulting coating comprises a silver concentration in the range of 0.05 wt % to 3.00 wt %.
8. The method according to claim 1 , wherein the forming the coating is performed by applying a thermal sprayed film comprising a calcium phosphate-based material and a silver material.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 15, 2026
From: KYOCERA CORPORATION
To: KYOCERA MEDICAL CORPORATION
Reel/Frame 074671/0210 →
Priority Claims (1)
JP 2012-022205
· Feb 3, 2012
· national
Continuity (4)
Continuation In Part
14376183
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