IP Library › Granted Patent US 50,453
Granted Patent E1
US 50,453 · App. 18/089,898 · Granted Jun 10, 2025

Indole derivatives as CFTR modulators

Inventors: Sara S. Hadida Ruah (La Jolla, CA); Peter D. J. Grootenhuis (San Diego, CA); Fredrick Van Goor (San Diego, CA); Jinglan Zhou (San Diego, CA); Brian Bear (Oceanside, CA); Mark T. Miller (San Diego, CA); Jason McCartney (Cardiff by the Sea, CA); Mehdi Michel Djamel Numa (San Diego, CA); Xiaoqing Yang (San Diego, CA)
Assignee: Vertex Pharmaceuticals Incorporated
A61K31/47A61K31/404A61K31/4045A61K31/405A61K31/407A61K31/41A61K31/4184A61K31/4192A61K31/454A61K31/5377A61K45/06C07D209/08C07D233/64C07D403/12C07D405/12C07D405/14C07D471/04C07D487/04G01N33/5035G01N2333/705G01N2500/10
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Quick Facts
Patent No.
US 50,453
App. No.
18/089,898
Granted
Jun 10, 2025
Kind
E1
Abstract

Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

Claims (6)

1. A compound of formula:

or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising

(i) a compound of formula:

(ii) a pharmaceutically acceptable carrier.

3. The composition of claim 2 , further comprising an additional agent wherein the additional agent is N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 14, 2025
From: YANG, XIAOQING
To: VERTEX PHARMACEUTICALS INCORPORATED
Reel/Frame 070512/0247 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 14, 2025
From: HADIDA RUAH, SARA S.; GROOTENHUIS, PETER D.J.; VAN GOOR, FREDRICK; ZHOU, JINGLAN; BEAR, BRIAN; MILLER, MARK T.; MCCARTNEY, JASON; NUMA, MEHDI MICHEL DJAMEL
To: VERTEX PHARMACEUTICALS INCORPORATED
Reel/Frame 070512/0265 →
Continuity (3)
Continuation In Part 11786001 · Apr 9, 2007
Provisional Application 60790459 · Apr 7, 2006
Reissue 11975297 · Oct 18, 2007
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