IP Library Granted Patent US 11,969,399
Granted Patent B2
US 11,969,399 · App. 18/108,940 · Granted Apr 30, 2024

Compositions and methods for remediating chemical warfare agent exposed skin

Inventors: Scott Noblitt (Fort Collins, CO); Edwin D. Neas (Nunn, CO)
Assignee: Armis Biopharma, Inc.
A61K31/19A61K9/06A61K31/327A61K33/40A61P17/02A61P39/02
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Quick Facts
Patent No.
US 11,969,399
App. No.
18/108,940
Granted
Apr 30, 2024
Kind
B2
Abstract

The present invention relates to chemical and biological warfare agent decontaminating compositions and methods for using the same to decontaminate animal skin and wounds thereon exposed to the agents. The compositions may comprise a peracid, a hydroperoxide, and a peroxyacid.

Claims (19)

1. A method of decontaminating an animal wound exposed to a chemical warfare agent, comprising contacting the wound with a decontaminating composition in an amount sufficient to decontaminate the wound, wherein the decontamination composition comprises active decontaminating compounds, and wherein the active decontaminating compounds consist of:

peracetic acid in an amount ranging from about 2% to about 6% by weight;

hydrogen peroxide in an amount ranging from about 3.2% to about 20% by weight; and

acetic acid in an amount ranging from about 2.8% to about 20% by weight.

2. The method of claim 1 , wherein the animal is exposed to a chemical warfare agent selected from the group consisting of a V-series nerve agent, G-series nerve agent, A-series nerve agent, mustard agent, and any combination thereof.

3. The method of claim 1 , wherein the composition is formulated in a form selected from the group consisting of a gel, sol, liquid, lotion, irrigation gel, and spray.

4. The method of claim 1 , wherein the decontamination composition is contacted with the wound by at least one of:

soaking the wound in a solution of the composition,

dispensing a pressurized solution of the composition onto the wound, or

applying a coating or layer of the composition on wound.

5. The method of claim 1 , wherein the animal is a human.

6. The method of claim 1 , wherein the decontaminating composition further comprises a stabilizer selected from the group consisting of etidronic acid, disodium ethyelendiamine tetraacetic acid, ethylenediaminetetraacetic acid, tetrasodium ethylene diamine tetraacetate, citramalic acid, dipicolinic acid, dipicolinic acid N-oxide, and a combination thereof.

7. The method of claim 1 , wherein the active decontaminating compounds consist of:

peracetic acid in an amount ranging from about 2% to about 6% by weight;

hydrogen peroxide in an amount ranging from about 5% to about 20% by weight; and

acetic acid in an amount ranging from about 5% to about 20% by weight.

8. The method of claim 1 , wherein the decontaminating composition is contacted with the wound by:

applying the composition to the wound for a period of time, followed by wiping the site of application to remove the composition.

9. The method of claim 8 , wherein the period of time is 15 minutes.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 13, 2023
From: NOBLITT, SCOTT; NEAS, EDWIN
To: ARMIS BIOPHARMA, INC.
Reel/Frame 062948/0964 →
Continuity (9)
Division 17326507 · May 21, 2021
Continuation In Part PCTUS2021012540 · Jan 7, 2021
Continuation 16900816 · Jun 12, 2020
Continuation 16736546 · Jan 7, 2020
Continuation In Part 16736546 · Jan 7, 2020
Provisional Application 63004858 · Apr 3, 2020
Provisional Application 62861810 · Jun 14, 2019
Provisional Application 62530045 · Jul 7, 2017
Related Publication 20230190688A1 · Jun 22, 2023