Methods for the prevention and treatment of hearing loss
In one aspect, use of compounds as active agents to treat a hearing impairment and to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. Momelotinib and Fedratinib exhibit excellent protection against antibiotic-induced hearing loss in zebrafish and mice when administered prophylactically. In one aspect, Momelotinib or Fedratinib can be used as a therapy for the treatment and/or prevention of hearing loss. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
1. A method to prevent or treat hearing loss comprising: administering to a mammal-in need thereof an effective amount of a pharmaceutical composition containing a therapeutically active agent, wherein the therapeutically active agent is mornelotinib.
2. The method of claim 1 , comprising protecting the inner ear cells from death caused by an antibiotic.
3. The method of claim 2 , wherein the antibiotic is an aminoglycoside.
4. The method of claim 1 , comprising protecting the inner ear cells from death caused by noise.
5. The method of claim 1 , comprising protecting the inner ear cells from death caused by cisplatin treatment.
6. A kit comprising: an active agent, wherein the active agent is momelotinib or a pharmaceutically acceptable salt thereof; and one or more of:
(A) at least one antibiotic;
and (B) at least one cancer drug.
7. The kit of claim 6 , wherein the at least one antibiotic is an aminoglycoside.
8. The kit of claim 6 , wherein the at least one cancer drug is cisplatin.