Granted Patent B2

US 12,662,488 · App. 18/117,978 · Granted Jun 23, 2026

Inventors: Christopher G. Nasveschuk (Stoneham, MA); Fabian Dey (Basel, CH); Annick Goergler (Colmar, FR); Roger Norcross (Basel, CH); Philipp Schmid (Basel, CH)

Assignee: C4 Therapeutics, Inc.

C07D487/10A61P35/00C07D519/00

Abstract

Claims (32)

1 . A method of treating cancer in a subject in need thereof comprising administering an effective amount of a compound of formula:

or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutical composition,

wherein:

Y is NH or CH 2 ;

n is 0 or 1;

A is selected from the group consisting of

i.) aryl;

ii.) aryl substituted by R 1 ;

iii.) heteroaryl; and

iv.) heteroaryl substituted by R 2 ;

R 1 is selected from the group consisting of

i.) —C(═O)—O—C 1-6 -alkyl;

ii.) —COOH;

iii.) —NH—C(═O)—C 1-6 -alkyl;

iv.) —NH 2 ; and

v.) —NO 2 ;

R 2 is selected from the group consisting of

i.) —COOH;

ii.) —C(═O)—O—C 1-6 -alkyl;

iii.) —NH 2 ; and

iv.) —NO 2 .

2 . The method of claim 1 , wherein the subject is a human.

3 . The method of claim 2 , wherein A is aryl.

4 . The method of claim 2 , wherein A is heteroaryl.

5 . The method of claim 3 , wherein Y is NH and n is 0.

6 . The method of claim 3 , wherein Y is NH and n is 1.

7 . The method of claim 3 , wherein Y is CH 2 and n is 0.

8 . The method of claim 3 , wherein Y is CH 2 and n is 1.

9 . The method of claim 4 , wherein Y is NH and n is 0.

10 . The method of claim 4 , wherein Y is NH and n is 1.

11 . The method of claim 4 , wherein Y is CH 2 and n is 0.

12 . The method of claim 4 , wherein Y is CH 2 and n is 1.

Assignments (4)

Priority Claims (1)

Continuity (3)

References Cited (185)