IP Library Granted Patent US 12,048,707
Granted Patent B2
US 12,048,707 · App. 18/119,251 · Granted Jul 30, 2024

Compositions and methods for the treatment of meibomian gland dysfunction

Inventors: Yair Alster (Tel Aviv, IL); Omer Rafaeli (Udim, IL); Kirsten Angela MacFarlane (Menlo Park, CA); Cary Reich (Santa Barbara, CA); Shimon Amselem (Rehovot, IL); Doron Friedman (Carme-Yosef, IL)
Assignee: AZURA OPHTHALMICS LTD.
A61K31/60A61K8/22A61K8/23A61K9/0048A61K9/06A61K31/122A61K31/17A61K31/19A61K31/327A61K31/4015A61K31/555A61K33/04A61K35/04A61K9/0014
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Quick Facts
Patent No.
US 12,048,707
App. No.
18/119,251
Granted
Jul 30, 2024
Kind
B2
Abstract

Described herein are compositions and methods for the treatment of meibomian gland dysfunction. Said compositions and methods comprise keratolytic agents, such as salicylic acid, selenium disulfide, or the like. Topical administration of said compositions to the eyelid margin or surrounding areas provides therapeutic benefit to patients suffering from meibomian gland dysfunction.

Claims (1)

1. A method for treating dry eye disease in an individual in need thereof, the method comprising topically administering to the eyelid of the individual a composition comprising a keratolytic agent and an ophthalmically or pharmaceutically acceptable vehicle or carrier, the composition being administered in a manner suitable to deliver the keratolytic agent to an eyelid margin of the individual.

Assignments (2)
CHANGE OF NAME Recorded May 18, 2023
From: M.G. THERAPEUTICS LTD.
To: AZURA OPHTHALMICS LTD.
Reel/Frame 063693/0618 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 18, 2023
From: ALSTER, YAIR; RAFAELI, OMER; MACFARLANE, KIRSTEN ANGELA; REICH, CARY; AMSELEM, SHIMON; FRIEDMAN, DORON
To: M.G. THERAPEUTICS LTD.
Reel/Frame 064050/0896 →
Continuity (8)
Continuation 17236258 · Apr 21, 2021
Continuation 16919749 · Jul 2, 2020
Continuation 16562374 · Sep 5, 2019
Continuation 16019253 · Jun 26, 2018
Continuation 15269833 · Sep 19, 2016
Continuation 14732622 · Jun 5, 2015
Provisional Application 62065716 · Oct 19, 2014
Related Publication 20230218642A1 · Jul 13, 2023
Cited By (4)
US 12,427,158 US 12,447,162 US 12,458,661 US 12,697,352