IP Library › Granted Patent US 12,508,427
Granted Patent B2
US 12,508,427 · App. 18/119,329 · Granted Dec 30, 2025

Closed-loop vagus nerve stimulation for the treatment of obesity

Inventors: Dominique Durand (Shaker Heights, OH); Joseph Marmerstein (Cleveland, OH); Grant McCallum (South Euclid, OH)
Assignee: CASE WESTERN RESERVE UNIVERSITY
A61N1/36139A61N1/36053A61N1/36085A61N1/3727
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Quick Facts
Patent No.
US 12,508,427
App. No.
18/119,329
Granted
Dec 30, 2025
Kind
B2
Abstract

Obesity and other medical conditions can be managed using a closed-loop system, which uses one or more implantable recording electrodes, a processing device, and one or more implantable stimulating electrodes. The one or more implantable recording electrodes can record signals from a portion of one or more subdiaphragmatic branches of a patient's vagus nerve. The processing device can be configured to: receive the signals from the portion of the one or more subdiaphragmatic branches of the patient's vagus nerve, perform signal processing to decode the signals from the portion of the one or more subdiaphragmatic branches of the patient's vagus nerve, and configure a stimulation to decrease the patient's hunger and/or increase the patient's satiety based on the decoded signals. The one or more implantable stimulating electrodes can deliver the configured stimulation to another portion of one or more subdiaphragmatic branches of the patient's vagus nerve.

Claims (35)

1 . A system comprising:

one or more implantable recording electrodes configured to be implanted within a patient's body to record vagal activity signals from a portion of one or more subdiaphragmatic branches of a patient's vagus nerve;

an external processing device coupled to the one or more implantable recording electrodes and one or more implantable stimulating electrodes and configured to receive user inputs, the processing device further configured to:

during a training period:

receive one or more user inputs indicating times of hunger, amount and length of food intake, and/or satiety feelings after meals of the patient and the vagal activity signals from the portion of the one or more subdiaphragmatic branches of the patient's vagus nerve, and

match at least a portion of spike clusters of the vagal activity signals with each of the times of hunger, amount and length of food intake, and/or satiety feelings after meals; and

after the training period;

receive the vagal activity signals from the portion of the one or more subdiaphragmatic branches of the patient's vagus nerve,

perform signal processing to decode the vagal activity signals from the portion of the one or more subdiaphragmatic branches of the patient's vagus nerve into a hunger, eating, and/or satiation event based on the match, and

configure a stimulation of an optimal type and timing based on the hunger, eating, and/or satiation event to decrease the patient's hunger and/or increase the patient's satiety; and

the one or more implantable stimulating electrodes configured to be implanted within the patient's body to deliver the configured stimulation to another portion of one or more subdiaphragmatic branches of the patient's vagus nerve to decrease the patient's hunger and/or increase the patient's satiety.

2 . The system of claim 1 , wherein the processing device is located outside a body of the patient.

3 . The system of claim 1 , wherein the one or more recording electrodes and the one or more stimulation electrodes are configured to be at least partially implanted within a portion of the one or more subdiaphragmatic branches of the patient's vagus nerve.

4 . The system of claim 1 , wherein the one or more recording electrodes, the processing device, and the one or more stimulating electrodes are combined in a single, implantable device.

5 . The system of claim 1 , wherein the stimulation is configured to treat obesity.

6 . The system of claim 1 , wherein the stimulation is configured to treat a gastric disease and/or a metabolic disease.

7 . The system of claim 1 , wherein the processing device is a signal processing chip or a computing device.

8 . The system of claim 1 , wherein the processing device saves the decoded vagal activity signals for future analysis.

9 . The system of claim 1 , wherein at least one of the one or more recording electrodes and the one or more stimulating electrodes comprise carbon nanotube yarn.

10 . The system of claim 9 , wherein at least one of the one or more recording electrodes and the one or more stimulating electrodes is configured to be implanted intrafascicularly.

11 . A method comprising:

during a training period:

receiving, by a system comprising a processor, one or more user inputs indicating times of hunger, amount and length of food intake, and/or satiety feelings after meals of a patient;

receiving, by the system, vagal activity signals recorded by one or more implanted recording electrodes in electrical communication with a portion of one or more subdiaphragmatic branches of a vagus nerve of the patient; and

matching at least a portion of spike clusters of the vagal activity signals with each of the times of hunger, amount and length of food intake, and/or satiety feelings after meals; and

after the training period:

receiving, by the system, the vagal activity signals recorded by the one or more implanted recording electrodes;

performing, by the system, signal processing to decode the vagal activity signals into a hunger, eating, and/or satiation event based on the matching during the training period;

configuring, by the system, a stimulation of an optimal type with an optimal timing based on the hunger, eating, and/or satiation event to decrease the patient's hunger and/or increase the patient's satiety; and

sending, by the system, the stimulation to one or more implantable stimulating electrodes implanted within the patient's body to be applied to another portion of one or more subdiaphragmatic branches of the patient's vagus nerve.

12 . The method of claim 11 , wherein the stimulation is configured to treat at least one of obesity, irritable bowel disease, diabetes, and/or hypertension.

13 . The method of claim 11 , wherein the stimulation is configured to reduce vagal activity or increase vagal activity based on the decoded vagal activity signals.

14 . The method of claim 13 , wherein the stimulation is configured to reduce the vagal activity when the vagal activity signals related to hunger are received.

15 . The method of claim 13 , wherein the stimulation is configured to increase the vagal activity when the vagal activity signals related to satiety are received.

16 . The method of claim 11 , wherein the system is located outside the patient's body.

Assignments (3)
CONFIRMATORY LICENSE Recorded Jan 31, 2024
From: CASE WESTERN RESERVE UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 066387/0029 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 16, 2023
From: DURAND, DOMINIQUE; MARMERSTEIN, JOSEPH; MCCALLUM, GRANT
To: CASE WESTERN RESERVE UNIVERSITY
Reel/Frame 065891/0580 →
CONFIRMATORY LICENSE Recorded Jun 26, 2023
From: CASE WESTERN RESERVE UNIVERSITY
To: UNITED STATES GOVERNMENT
Reel/Frame 064090/0760 →
Continuity (2)
Provisional Application 63317997 · Mar 9, 2022
Related Publication 20230310863A1 · Oct 5, 2023
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