Injectable antibiotic formulations and use thereof
Provided herein are pharmaceutically acceptable compositions containing macrolide antibiotics, in particular azithromycin. In particular, compositions containing azithromycin with low toxicity, especially for administration to felines, are provided herein.
1. A non-aqueous composition, comprising:
(i) a macrolide;
(ii) at least two solvents; and
(iii) a surfactant;
wherein a first solvent is triacetin, and wherein the triacetin is present in an amount of about 23 to 70% w/w, wherein a second solvent is selected from the group consisting of a triglyceride, acetylated monoglyceride, propyldicaprylates/dicaprates and caprylic/capric triglycerides, and wherein the second solvent is present in an amount of about 20-60%.
2. The composition of claim 1 , wherein the macrolide is azithromycin.
3. The composition of claim 1 , wherein the surfactant is selected from the group consisting of castor oil, hydrogenated castor oil, Polyoxyl 15 Hydroxystearate, polyethylene glycol 40 hydrogenated castor oil, propyl dicaprylate/dicaprate, D-α-tocopherol polyethylene glycol 1000 succinate (TPGS), polysorbate or lecithin.
4. The composition of claim 3 , wherein the surfactant is Polyoxyl 15 Hydroxystearate.
5. The composition of claim 2 , wherein azithromycin is present in an amount of about 7.0% w/w.
6. The composition of claim 1 , wherein the composition is formulated for injection.
7. The composition of claim 1 , wherein the second solvent is a triglyceride solvent.
8. The composition of claim 7 , wherein the triglyceride solvent is caprylic or caprylic/capric triglycerides.
9. The composition of claim 7 , wherein the triglyceride solvent is present in an amount of about 54.0% w/w.
10. The composition of claim 8 , wherein the triglyceride solvent is a C8 triglyceride, a C10 triglyceride, or a mixture thereof.
11. The composition of claim 1 , wherein the triacetin is present in an amount of about 38% w/w.
12. The composition of claim 4 , wherein the Polyoxyl 15 Hydroxystearate is present in an amount of about 1% w/w.
13. The composition of claim 1 , wherein the macrolide is a mono- or di-hydrate macrolide.
14. A method of treating an infection in a subject weighing less than about 100 pounds, comprising administering an effective amount of a composition of claim 1 .
15. The method of claim 14 , further comprising administering an additional antibiotic in combination with a non-aqueous composition comprising:
(i) a macrolide;
(ii) at least two solvents; and
(iii) a surfactant;
wherein a first solvent is triacetin, and wherein the triacetin is present in an amount of about 23 to 70% w/w, wherein a second solvent is selected from the group consisting of a triglyceride, acetylated monoglyceride, propyldicaprylates/dicaprates and caprylic/capric triglycerides, and wherein the second solvent is present in an amount of about 20-60%.
16. The method of claim 14 , wherein the subject is a feline.
17. The method of claim 14 , wherein the composition is administered by injection.