Granted Patent
B2
US 12,213,951 · App. 18/124,460 · Granted Feb 4, 2025
Treatment of autism with cannabidiol
Inventors:
Terri Sebree (Gladwyne, PA); Marcel Bonn-Miller (Lexington, NC); Donna Gutterman (Raleigh, NC)
Assignee:
Harmony Biosciences Management, Inc.
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Abstract
The present technology relates to a method of treating one or more behavioral symptoms of Autism Spectrum Disorder (ASD) in a subject by transdermally administering an effective amount of cannabidiol (CBD) to the subject wherein one or more behavioral symptoms of ASD are treated in the subject.
Claims (10)
1. A method of treating a human suffering from an autism spectrum disorder comprising:
transdermally administering via a gel or cream a therapeutically effective amount of purified cannabidiol to the human suffering from the autism spectrum disorder to effectively treat the autism spectrum disorder in the human in need thereof,
wherein the gel or cream is administered to the upper arm.
2. The method of claim 1 , wherein the cannabidiol is (-)-cannabidiol.
3. The method of claim 1 , wherein the therapeutically effective amount of cannabidiol is 250 mg total daily.
4. The method of claim 1 , wherein the therapeutically effective amount of cannabidiol is 500 mg total daily.
5. The method of claim 1 , wherein the cannabidiol is formulated as a permeation-enhanced gel.
6. The method of claim 1 , wherein the cannabidiol is administered in a single-daily dose.
7. The method of claim 1 , wherein the cannabidiol is administered in two daily doses.
8. The method of claim 1 , wherein the therapeutically effective amount of cannabidiol is between about 50 mg to 500 mg total daily.
Assignments (3)
SUPPLEMENTAL CONFIRMATORY GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS
Recorded May 18, 2026
From: HARMONY BIOSCIENCES MANAGEMENT, INC. (F/K/A ZYNERBA PHARMACEUTICALS, INC.)
To: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 075642/0639 →
CHANGE OF NAME
Recorded Dec 12, 2024
From: ZYNERBA PHARMACEUTICALS, INC.
To: HARMONY BIOSCIENCES MANAGEMENT, INC.
Reel/Frame 069612/0961 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Mar 21, 2023
From: SEBREE, TERRI; BONN-MILLER, MARCEL; GUTTERMAN, DONNA
To: ZYNERBA PHARMACEUTICALS, INC.
Reel/Frame 063052/0055 →
Continuity (8)
Continuation
16144632
· Sep 27, 2018
Provisional Application
62632532
· Feb 20, 2018
Provisional Application
62564834
· Sep 28, 2017
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