Devices, methods, and systems to collect, concentrate, store, and analyze chemical substances
Concentrating devices, systems, and methods include those for separating fluids to be sensed (e.g., analytes, such as volatile organic compounds (VOCs) and/or other chemical substances) from other fluid (e.g., a carrier gas, air, etc.) of a fluid mixture received from a target area of a subject's anatomy (e.g., a subject's skin, a wound on a subject, etc.). In some cases, the concentration system may include a housing and a rotor positioned in a compartment of the housing. The housing may receive a fluid mixture in the compartment and rotation of the rotor relative to the housing may separate fluid to be sensed in the fluid mixture from other fluid of the fluid mixture.
1 . A gas concentrator, comprising;
a housing defining a compartment, an inlet to the compartment, and an outlet from the compartment;
a rotor positioned in the compartment and configured to rotate about a rotational axis and relative to the housing; and
wherein the housing is configured to receive through the inlet and into the compartment a gas mixture including a first gas and rotation of the rotor relative to the housing separates the first gas from a second gas of the gas mixture and causes the first gas to move radially outward,
wherein the outlet is a first outlet and the housing defines a second outlet, the second outlet is positioned closer to the rotational axis of the rotor than the first outlet; and
wherein the rotor comprises:
one or more slots extending radially outward and through the rotor from a first side of the rotor to a second side of the rotor and the first gas passing through the one or more slots is configured to exit through the first outlet;
a first rotator cover covering at least a portion of the first side of the rotor and at least part of the one or more slots, the first rotator cover defining an inlet port for the gas mixture to the one or more slots; and
a second rotator cover covering at least a portion of the second side of the rotor and at least part of the one or more slots, the second rotator cover defining a first outlet port from the one or more slots and a second outlet port from the one or more slots that is spaced radially inward from the first outlet port; and
wherein the first outlet port is configured to be in fluid communication with the first outlet and the second outlet port is configured to be in fluid communication with the second outlet.
2 . The gas concentrator of claim 1 , wherein rotation of the rotor relative to the housing causes the first gas to exit the compartment through the outlet.
3 . The gas concentrator of claim 1 , wherein:
the gas mixture enters the compartment at a radial location closer to the rotational axis of the rotor than a radial location at which the first gas exits the compartment; and
the rotation of the rotor causes the first gas to move radially outward from the rotational axis to the radial location at which the first gas exits the compartment.
4 . The gas concentrator of claim 1 , wherein the rotor comprises one or more holes extending through the rotor from a first side of the rotor to a second side of the rotor and gas passing through the one or more holes is configured to exit through the second outlet.
5 . The gas concentrator of claim 1 , further comprising:
a plurality of rotors positioned in the compartment and configured to rotate relative to the housing.
6 . The gas concentrator of claim 5 , wherein each rotor of the plurality of rotors comprises one or more holes extending through the rotor from a first side of the rotor to a second side of the rotor.
7 . The gas concentrator of claim 1 , further comprising:
a detector in fluid communication with the compartment and configured to detect one or more parameters of the first gas.
8 . The gas concentrator of claim 7 , wherein the detector is located in the compartment.
9 . A fluid concentration system, comprising:
a fluid concentrator comprising:
a housing defining a compartment, an inlet to the compartment, and an outlet from the compartment;
a rotor positioned in the compartment and configured to rotate relative to the housing; and
wherein rotation of the rotor relative to the housing is configured to cause a fluid mixture received in the compartment to rotate and a fluid to be sensed of the fluid mixture to move radially outward toward the outlet;
a fluid path in communication with the outlet and configured to transport the fluid to be sensed from the outlet;
a collector in communication with the fluid path, wherein the collector is configured to adsorb the fluid to be sensed;
a detector in communication with the fluid path; and
wherein the detector comprises a colorimetric sensor array configured to detect a parameter of the fluid to be sensed.
10 . The fluid concentration system of claim 9 , further comprising:
a plurality of fluid concentrators including the fluid concentrator, each of the plurality of fluid concentrators comprising:
a housing defining a compartment, an inlet to the compartment, and an outlet from the compartment;
a rotor positioned in the compartment and configured to rotate relative to the housing; and
wherein rotation of the rotor relative to the housing is configured to cause a fluid mixture received in the compartment to rotate and a fluid to be sensed of the fluid mixture to move toward the outlet; and
wherein each of the plurality of fluid concentrators of the plurality of fluid concentrators is in fluid communication with one other of the plurality of fluid concentrators.
11 . The fluid concentration system of claim 10 , further comprising:
wherein a first fluid concentrator of the plurality of fluid concentrators receives the fluid mixture through the inlet of the first fluid concentrator; and
wherein the fluid path fluidly couples the outlet of one of the plurality of fluid concentrators to the inlet of another of the plurality of fluid concentrators.
12 . The fluid concentration system of claim 10 , wherein:
for two or more of the plurality of fluid concentrators, the outlet is a first outlet and the housing defines a second outlet, the second outlet is positioned closer to a rotational axis of the rotor than the first outlet;
the first outlet of a first fluid concentrator of the plurality of fluid concentrators is fluidly coupled to a first outlet of another other fluid concentrator of the plurality of fluid concentrators; and
the second outlet of the first fluid concentrator is fluidly coupled to an inlet of a second fluid concentrator of the plurality of fluid concentrators.
13 . A method comprising:
receiving a mixture of fluid at a fluid concentrator, the mixture of fluid comprising a fluid of volatile organic compounds (VOCs) from a subject and other fluid;
separating, using the fluid concentrator, the fluid of VOCs from the subject from the other fluid of the mixture of fluid, wherein separating the fluid of VOCs from the subject from other fluid of the mixture of fluid comprises rotating the mixture of fluid to cause the fluid of VOCs from the subject to move radially outward relative to the other fluid of the mixture of fluid; and
outputting from the fluid concentrator the separated fluid of VOCs from the subject;
outputting the other fluid of the mixture of fluid from the fluid concentrator to the subject for mixing with VOCs from the subject; and
receiving the other fluid that has mixed with VOCs from the subject at the fluid concentrator;
wherein the subject is a mammalian body and the VOCs are from the mammalian body.
14 . The method of claim 13 , further comprising:
wherein the fluid concentrator is a first fluid concentrator and the other fluid of the mixture of fluid is outputted from the first fluid concentrator to an inlet of a second fluid concentrator.