Granted Patent
B2
US 12,397,026 · App. 18/137,752 · Granted Aug 26, 2025
Dietary supplement
Inventors:
Sophie Moille (Evian-les-Bains, FR); Irma Silva Zolezzi (Carrouge, CH); Edwin Alberto Habeych Narvaez (Lausanne, CH); Nicola Galaffu (Ornex, FR); Bertrand Bourqui (Murist, CH); Sara Colombo Mottaz (La Conversion, CH)
Assignee:
Societe des Produits Nestle S.A.
A61K35/747A23L33/135A23L33/16A23L33/40A61K9/0053A61K9/0095A61K9/107A61K9/14A61K9/145A61K33/26A61K33/42A61K35/741A61P3/02A61P3/10A61P7/06A23V2002/00A23V2400/175A23V2400/531A23V2400/533
View Patent ↗
Loading inventors, assignments & file history…
Abstract
An oral composition comprising at least one probiotic bacteria selected from the genera: Lactobacillus, Bifidobacterium , and Bacillus , and ferric pyrophosphate.
Claims (15)
1. An oral composition comprising:
at least one probiotic bacteria selected from the group consisting of: Lactobacillus rhamnosus CGMCC 1.3724, Bifidobacterium lactis CNCM I-3446, and a mixture thereof;
ferric pyrophosphate, wherein the ferric pyrophosphate has a particle size distribution D 90 of 200 microns or less, a particle size distribution D 97 of 25 microns or less, and an average particle size of about 0.001 microns to about 10 microns; and
at least one pharmaceutically acceptable additive or excipient selected from the group consisting of stabilizers, fillers, emulsifiers, surfactants, solubilising agents, adsorbents, flowing agents, buffers, lubricants, wetting agents, carriers, antioxidants, thickeners, anticaking agents, coating agents, taste masking agents, preservatives, flavouring agents and dyes.
2. The composition according to claim 1 , wherein the ferric pyrophosphate is in the form of a colloid.
3. The composition according to claim 1 , wherein the at least one probiotic bacteria is the mixture of Lactobacillus rhamnosus CGMCC 1.3724 and Bifidobacterium lactis CNCM I-3446.
4. The composition according to claim 1 , wherein the at least one probiotic bacteria comprises Lactobacillus rhamnosus CGMCC 1.3724.
5. The composition according to claim 1 , wherein the at least one probiotic bacteria comprises Bifidobacterium lactis CNCM I-3446.
6. The composition according to claim 1 , further comprising one or more micronutrients.
7. The composition according to claim 1 , in the form of a dietary supplement.
8. The composition of claim 1 , wherein the composition is an emulsion comprising at least one emulsifier.
9. The composition of claim 8 , wherein the at least one emulsifier comprises at least one of fatty acid ester.
10. The composition of claim 1 , wherein the particle size distribution D 90 of the ferric pyrophosphate is 100 microns or less.
11. The composition of claim 1 , wherein the particle size distribution D 97 of the ferric pyrophosphate is 15 microns or less.
12. The composition of claim 1 , wherein the ferric pyrophosphate has an average particle size of about 0.1 microns to about 0.5 microns.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 30, 2025
From: MOILLE, SOPHIE; SILVA ZOLEZZI, IRMA; NARVAEZ, EDWIN ALBERTO-HABEYCH; GALAFFU, NICOLA; BOURQUI, BERTRAND; MOTTAZ, SARA COLOMBO
To: NESTEC S.A.
Reel/Frame 072290/0812 →
MERGER
Recorded Jul 30, 2025
From: NESTEC S.A.
To: SOCIETE DES PRODUITS NESTLE S.A.
Reel/Frame 072291/0086 →
Priority Claims (1)
EP 1517552
· Jun 11, 2015
· regional
Continuity (2)
Division
15573601
References Cited (76)
US 6812022B1
· Aonuma
· 2004
[cited by examiner]
US 9241923B2
· Kuang et al.
· 2016
[cited by applicant]
US 9414621B2
· Benyacoub
· 2016
[cited by examiner]
US 20070116699A1
· Holsworth
· 2007
[cited by applicant]
US 20080233239A1
· Avramis
· 2008
[cited by examiner]
CA 2347891
· 2001
[cited by applicant]
CN 101601421
· 2009
[cited by applicant]
CN 102014673
· 2011
[cited by applicant]
CN 102144670
· 2011
[cited by applicant]
CN 101869141
· 2012
[cited by applicant]
CN 102940037
· 2013
[cited by applicant]
CN 103988863
· 2014
[cited by applicant]
EP 0974269
· 2000
[cited by applicant]
EP 2258217
· 2010
[cited by applicant]
WO 0115714
· 2001
[cited by applicant]
WO 2008113665
· 2008
[cited by applicant]
WO 2009004076
· 2009
[cited by applicant]
WO 2009127566
· 2009
[cited by applicant]
WO 2011023689
· 2011
[cited by applicant]
WO 2011114916
· 2011
[cited by applicant]
WO 201217893
· 2012
[cited by applicant]
WO 2013055439
· 2013
[cited by applicant]
WO 2013055444
· 2013
[cited by applicant]
WO 2013141139
· 2013
[cited by applicant]
WO 2014148910
· 2014
[cited by applicant]
WO 2015121461
· 2015
[cited by applicant]
Sakaguchi et al. Int J Vitam Nutr Res., 2004, 74 (1), pp. 3-9.
[cited by examiner]
Juana Fernández-López et al(Chemical and technological properties of bologna-type sausages with added black quinoa wet-milling coproducts as binder replacer, Elsevier Food Chemistry 310 (2020) 125936) (Year: 2019).
[cited by applicant]
Navam Hettiarachchy et al (Gelling of Plant Based Proteins, Product Design and Engineering: Formation of Gels and Pastes, First Edition) (Year: 2013).
[cited by applicant]
Qian Guo et al(Microstructure and rheological properties of psyllium polysaccharide gel, Elsevier Food Hydrocolloids 23 (2009) 1542-1547) (Year: 2008).
[cited by applicant]
Alyssa Rimmer (5 New Ways to Use Quinoa, Simply Quinoa) (Year: 2017).
[cited by applicant]
“Email Correspondence with CGMCC”, 2021, 2 Pages.
[cited by applicant]
“The Chinese General Microbiological Culture Collection Center”, Retrieved from (www.cgmcc.net/english/deposit), Nov. 23, 2021, pp. 1-2.
[cited by applicant]
Barrett et al., “Probiotics for Preventing Gestational Diabetes”, Cochrane Database of Systematic Reviews, vol. 2, 2014, pp. 1-26.
[cited by applicant]
Lindsay et al., “Prematurity, Physiolgy”, American Journal of Obstetrics & Gynecology, 2014, p. S342.
[cited by applicant]
Lindsay et al., “Impact of Probiotics in Women with Gestational Diabetes Mellitus on Metabolic Health: A Randomized Controlled Trial”, American Journal of Obstetrics & Gynecology, 2015, pp. 496.e1-496.e11.
[cited by applicant]
Callaway et al., “Probiotics for the Prevention of Gestational Diabetes Mellitus in Overweight and Obese Women: Findings from the Spring Double-Blind Randomized Controlled Trial”, Diabetes Care, vol. 42, 2019, pp. 364-3…
[cited by applicant]
Datasheet for the Decision of Case No. T 1941 /12, Dec. 16, 2014, 22 Pages.
[cited by applicant]
“Masterpiece Organic Agriculture Nutrition Powder”, Mintel, Record Id 272224, 2004, 2 Pages.
[cited by applicant]
“Student's T-Test”, Wikipedia, 2022, 10 Pages.
[cited by applicant]
“Terms and Conditions of Access and use General”, 2017, 5 Pages.
[cited by applicant]
“Declaration of Edwin Habeych”, May 10, 2022, 2 Pages.
[cited by applicant]
Martinez et al., “Measuring the Potential Impact of New and Reformulated Bread and Breakfast Cereal Products on Nutrient Intakes”, United States Department of Agriculture, 2021, pp. 1-25.
[cited by applicant]
Fu et al., “Research Progress of Iron Supplements for Human Body”, HeilongJiang Medicine Journal, vol. 19, Issue No. 3, Dec. 31, 2006, pp. 207-208.
[cited by applicant]
Hao et al., “Interventions for Iron Deficiency Anemia”, Chinese Journal of Eugenics and Genetics, vol. 14, Issue No. 10, Dec. 31, 2006, pp. 3-5.
[cited by applicant]
Jiang et al., “Iron”, Pictorial Book of Health Food, May 31, 2015, pp. 129-132.
[cited by applicant]
Office Action Received for Application No. CN201680029716.1, mailed on Sep. 27, 2020, 21 Pages(8 Pages of English Translation and 13 Pages of Official Copy).
[cited by applicant]
Enlargement of the Six Product Images of Vanilla Mango Flavoured Formulated Milk for Pregnant Women, Mintel, Record ID: 2577737, 2014, 5 Pages.
[cited by applicant]
Application originally filed on Jun. 9, 2016 for PCT Patent Application No. PCT/EP2016/063170, 45 pages.
[cited by applicant]
Sakaguchi et al., “Iron Absorption and Bioavailability in Rats of Micronized Dispersible Ferric Pyrophosphate”, International Journal for Vitamin and Nutrition Research, vol. 74, Issue No. 1, 2004, pp. 3-9.
[cited by applicant]
Rossi et al., “Colloidal Iron(III) Pyrophosphate Particles”, Food Chemistry, vol. 151, 2014, pp. 243-247.
[cited by applicant]
Enos et al., “Probiotics and Nutrients for the First 1000 Days of Life in the Developing World”, Beneficial Microbes, vol. 4, Issue No. 1, Mar. 2013, p. 3-16.
[cited by applicant]
Hummelen et al., “Effect of Micronutrient and Probiotic Fortified Yogurt on Immune-Function of Anti-Retroviral Therapy Naive HIV Patients”, Nutrients, vol. 3, Issue No. 10, 2011, pp. 897-909.
[cited by applicant]
Hemsworth et al., “The Development of Micronutrient Supplemented Probiotic Yogurt for People Living with HIV: Laboratory Testing and Sensory Evaluation”, Innovative Food Science and Emerging Technologies, vol. 12, Issue…
[cited by applicant]
“Product data sheet FD-DVS YF-L812 Yo-Flex®”, Chr. Hansen, Aug. 12, 2011, 4 Pages.
[cited by applicant]
Notice of Oppostition for Appl No. 1673314.5-1105 dated Jan. 28, 2021.
[cited by applicant]
Choi et al., “Impact of Iron Encapsulation within the Interior Aqueous Phase of Water-in-Oil-in-Water Emulsions on Lipid Oxidation”, Food Chemistry, vol. 116, Issue No. 1, 2009, pp. 271-276.
[cited by applicant]
Gueimonde et al., “Viability and Diversity of Probiotic Lactobacillus and Bifidobacterium Populations Included in Commercial Fermented Milks”, Food Research International, vol. 37, Issue No. 9, Dec. 31, 2004, pp. 839-85…
[cited by applicant]
“Full Step Advanced Nutritional Supplement”, In nova, Product ID: 1766054, Jun. 2014, 2 Pages.
[cited by applicant]
“Anmum Materna Milk Powder for Pregnant Women”, In nova, Product ID: 1499535, Jun. 2014, 2 Pages.
[cited by applicant]
“Celia Mama Nutritional Milk Preparation with Vanilla Flavor”, Innova, Product ID: 1960070, Feb. 2015, 2 Pages.
[cited by applicant]
“Friso Mum Gold Nutritional Supplement for Pregnant and Breast Feeding Women”, Innova, Product ID: 1119373, Mar. 2012, 2 Pages.
[cited by applicant]
“Frisomum Gold Nutritional Supplement for Pregnant Women and Lactating Moms”, Innova, Product ID: 1888965, Dec. 2014, 2 Pages.
[cited by applicant]
“Babecare Milk Powder for Pregnant and Lactating Mothers”, Innova, Product ID: 1485661, May 2014, 2 Pages.
[cited by applicant]
Notification Receipt China General Microbiological Culture Collection Centre No. 1.3724, Nov. 5, 2004, 1 Page.
[cited by applicant]
European Office Action for Appl No. 16733415.5 dated Jan. 28, 2021.
[cited by applicant]
Written Opinion of the International Searching Authority received for PCT Patent Application No. PCT/EP2016/063170, mailed on Sep. 19, 2016, 3 Pages.
[cited by applicant]
“Vanilla Mango Flavoured Formulated Milk for Pregnant Women”, Mintel, Record ID: 2577737, Jul. 2014, 4 Pages.
[cited by applicant]
“Step O Nutritional Supplement for Pregnant and Lactating Women”, Mintel, Record ID: 1795506, May 2012, 4 Pages.
[cited by applicant]
“Nutritional Supplement for Pregnant Women & Breastfeeding Mothers”, Mintel, Record ID: 1740436, Mar. 2012, 5 Pages.
[cited by applicant]
Wegmuller et al., “Particle Size Reduction and Encapsulation Affect the Bioavailability of Ferric Pyrophosphate in Rats”, The Journal of Nutrition, vol. 134, Issue No. 12, 2004, pp. 3301-3304.
[cited by applicant]
Notice of Opposition for Appl No. 16733314.5 dated Jan. 28, 2021.
[cited by applicant]
Hartman-Craven et al., Relative bioavailability of iron and folic acid from a new powdered supplement compared to a traditioanl tablet in pregnant women, BMC Pregnancy and Childbirth, 2009, 9:33.
[cited by applicant]
Fidler et al., A micronsed, dispersible ferric pyrophosphate with high relative bioavailability in man, British Journal of Nutrition, (2004 ), 91, 107-112.
[cited by applicant]
Product Catalogue—Dr. Paul Lohmann (last visited May 22, 2020).
[cited by applicant]
Mayo Clinic, Gestational Diabetes—Symptoms and Causes (pp. 1-7) (last visited Nov. 11, 2019).
[cited by applicant]