Methods, compositions, and systems for device implantation
Methods, systems, and compositions are provided for implanting an implantable device into a biological tissue (e.g., muscle, brain). A subject implantable device includes: (i) a biocompatible substrate, (ii) a conduit (e.g., an electrode, a waveguide) that is disposed on the biocompatible substrate, and (iii) an engagement feature (e.g., a loop) for reversible engagement with an insertion needle. The biocompatible substrate can be flexible (e.g., can include polyimide). The implantable device is implanted using an insertion needle that includes an engagement feature corresponding to the engagement feature of the implantable device. To implant, an implantable device is reversibly engaged with an insertion needle, the device-loaded insertion needle is inserted into a biological tissue (e.g., to a desired depth), and the insertion needle is retracted, thereby disengaging the implantable device from the insertion needle and allowing the implantable device to remain implanted in the biological tissue.
1. A system for implanting an implantable device, comprising:
(a) an implantable device comprising:
a biocompatible substrate;
a conduit embedded in the biocompatible substrate; and
an engagement feature that is: (i) fabricated within the biocompatible substrate at or near an end of the implantable device, and (ii) configured for reversible engagement with a corresponding engagement feature of an insertion needle; and
(b) an insertion needle comprising an engagement feature that: (i) is a static protrusion on an external surface of the insertion needle, and (ii) corresponds to, and is configured to reversibly engage, the engagement feature of the implantable device.
2. The system of claim 1 , wherein the conduit is a conductor of electrons and is an electrode for stimulating or recording.
3. The system of claim 1 , wherein the conduit is a waveguide.
4. The system of claim 1 , wherein the implantable device comprises two or more conduits.
5. The system of claim 4 , wherein the two or more conduits include two or more electrodes.
6. The system of claim 1 , wherein the biocompatible substrate comprises the engagement feature of the implantable device.
7. The system of claim 1 , wherein the engagement feature of the implantable device is a loop.
8. The system of claim 1 , wherein the biocompatible substrate of the implantable device is a non-conductive substrate.
9. The system of claim 1 , wherein the biocompatible substrate of the implantable device comprises an inert polymeric material.
10. The system of claim 1 , wherein the biocompatible substrate of the implantable device comprises polyimide.
11. The system of claim 1 , wherein the biocompatible substrate of the implantable device includes one or more anchor arms configured to flex orthogonal to the body of the implantable device, while remaining connected to the implantable device, in order to facilitate anchoring of the implantable device.
12. The system of claim 1 , wherein the implantable device is a member of a cartridge comprising a plurality of the implantable devices.
13. The system of claim 1 , wherein the engagement feature of the insertion needle is positioned in a distal region of the insertion needle.
14. The system of claim 1 , wherein the engagement feature of the insertion needle is positioned within 100 μm of the distal end of the insertion needle.
15. The system of claim 1 , wherein the insertion needle has a maximum cross sectional area of 4000 μm 2 or less.
16. The system of claim 1 , wherein the engagement feature of the insertion needle is a flange.
17. The system of claim 16 , wherein the insertion needle comprises two connected wires and one of the two wires is shorter than the other such that the distal end of the shorter wire forms the flange.
18. The system of claim 16 , wherein the flange is a notch or a ledge.
19. The system of claim 1 , wherein the engagement feature of the insertion needle is reversibly engaged with the engagement feature of the implantable device.
20. The system of claim 19 , wherein the insertion needle is configured to penetrate through the engagement feature of the implantable device.