Treatment of HER2 positive cancers
In one aspect, the present invention provides a method for treating or ameliorating the effects of a HER2 positive cancer in a subject. In some embodiments, the method comprises administering a combination therapy comprising an anti-HER2 antibody and tucatinib. In some embodiments, the method further comprises administering a chemotherapeutic agent (e.g., an antimetabolite) to the subject. Pharmaceutical compositions and kits are also provided herein.
1. A method for treating a HER2-positive cancer in a subject, the method comprising administering tucatinib and trastuzumab to the subject, wherein:
the tucatinib is administered in an amount of about 300 mg twice per day; and
the trastuzumab is administered at an amount of about 6 mg to 8 mg per kg of the subject's body weight once every three weeks;
wherein the HER2-positive cancer is selected from the group consisting of: colorectal cancer, gastric cancer, lung cancer, biliary cancer, and esophageal cancer.
2. The method of claim 1 , wherein the tucatinib is administered orally.
3. The method of claim 1 , wherein the trastuzumab is administered orally.
4. The method of claim 1 , wherein the trastuzumab is administered subcutaneously.
5. The method of claim 1 , wherein the HER2-positive cancer is lung cancer.
6. The method of claim 1 , wherein the HER2-positive cancer is lung cancer, and the lung cancer is non-small cell lung cancer.
7. The method of claim 1 , wherein the HER2-positive cancer biliary cancer.
8. The method of claim 1 , wherein the HER2-positive cancer is biliary cancer, and the biliary cancer is cholangiocarcinoma.
9. The method of claim 1 , wherein the HER2-positive cancer is colorectal cancer.
10. The method of claim 1 , wherein the HER2-positive cancer is gastric cancer.
11. The method of claim 1 , wherein the HER2-positive cancer is esophageal cancer.
12. The method of claim 1 , wherein the subject had prior treatment with trastuzumab, pertuzumab, or T-DM1.
13. The method of claim 1 , wherein the HER2-positive cancer comprises a cell that has a wild-type KRAS exon 2 genotype, a wild-type NRAS genotype, or a wild-type BRAF genotype.
14. The method of claim 1 , wherein the subject has a HER2-positive cancer which is relapsed or refractory to a standard of care.
15. The method of claim 1 , wherein treating the subject results in a tumor growth inhibition (TGI) index of at least about 85%.
16. The method of claim 1 , wherein treating the subject results in a TGI index that is greater than the TGI index observed when using an anti-HER2 antibody or tucatinib alone.
17. The method of claim 1 , wherein the subject has one or more adverse events and is further administered an additional therapeutic agent to eliminate or reduce the severity of the one or more adverse events.
18. The method of claim 1 , wherein the subject is at risk of developing one or more adverse events and is further administered an additional therapeutic agent to prevent or reduce the severity of the one or more adverse events.
19. The method of claim 1 , wherein the subject is a human.