IP Library › Granted Patent US 12,678,401
Granted Patent B2
US 12,678,401 · App. 18/143,944 · Granted Jul 14, 2026

Implantable devices for drug delivery with reduced burst release

Inventors: Rajesh A. Patel (South San Francisco, CA); Sunil Sreedharan (South San Francisco, CA); Sunil R. Bhonsle (South San Francisco, CA)
Assignee: ReacX Pharmaceuticals, Inc.
A61K9/0024A61K9/4808A61K9/4816A61K9/4833A61K31/197A61K31/4045A61K31/4458A61K31/485A61K31/506A61K38/26B29C48/06B29C48/21B29K2001/08B29K2023/083B29K2105/0035B29K2995/006B29L2031/753
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Quick Facts
Patent No.
US 12,678,401
App. No.
18/143,944
Filed
May 5, 2023
Granted
Jul 14, 2026
Kind
B2
Art Unit
1636
USPC
424/422
Abstract

The invention provides implantable drug delivery devices comprising a core comprising a polymer (or polymer blend) and one or more drugs or pharmaceutical substances, and an outer shell comprising a polymer (or polymer blend) and one or more porogen materials. The invention reduces burst release of drug. Pharmaceuticals such as triiodothyronine (T3) or ropinirole can be delivered by the devices.

Claims (27)

1 . An implantable device for delivery of a pharmaceutical substance or drug, wherein the implantable device, after implantation, comprises:

a core comprising: (i) a polymeric material consisting of poly(vinyl alcohol); and (ii) the pharmaceutical substance or drug; and

a porous outer shell comprising poly(vinyl alcohol) and poly-L-lactic acid-co-glycolic acid, wherein the porous outer shell is free of the pharmaceutical substance or drug, the porous outer shell having a thickness of about 1 micrometer to about 5 micrometers,

wherein the implantable device is rod-shaped and has a length of about 0.5 cm to 10 cm and a diameter of about 1 mm to about 8 mm, and wherein, after implantation into a patient, the drug diffuses through the porous outer shell.

2 . The implantable device of claim 1 , wherein the length of the implantable device is from about 0.5 cm to about 3 cm.

3 . The implantable device of claim 1 , wherein the length of the implantable device is from about 0.5 cm to about 2 cm.

4 . The implantable device of claim 1 , wherein the length of the implantable device is from about 0.5 cm to about 1.5 cm.

5 . The implantable device of claim 1 , wherein the length of the implantable device is from about 0.5 cm to about 1 cm.

6 . The implantable device of claim 1 , wherein the length of the implantable device is from about 1 cm to about 3 cm.

7 . The implantable device of claim 1 , wherein the length of the implantable device is about 0.5 cm.

8 . The implantable device of claim 1 , wherein the length of the implantable device is about 1 cm.

9 . The implantable device of claim 1 , wherein the diameter of the implantable device is about 1 to about 7 mm in diameter.

10 . The implantable device of claim 1 , wherein the diameter of the implantable device is about 1 to about 3 mm in diameter.

11 . The implantable device of claim 1 , wherein the diameter of the implantable device is about 1 mm.

12 . An implantable device for delivery of a pharmaceutical substance or drug, wherein the implantable device, after implantation, comprises:

a polymeric core consisting of poly(vinyl alcohol) and the pharmaceutical substance or drug; and

a porous outer shell consisting of poly(vinyl alcohol) and poly-L-lactic acid-co-glycolic acid, wherein the porous outer shell is free of the pharmaceutical substance or drug, the porous outer shell having a thickness of about 1 micrometer to about 5 micrometers,

wherein the implantable device is rod-shaped and has a length of about 0.5 cm to 10 cm in length, wherein the diameter of the implantable device is about 1 mm to about 7 mm, and wherein, after implantation into a patient, the drug diffuses through the porous outer shell.

13 . The implantable device of claim 12 , wherein the length of the implantable device is from about 0.5 cm to about 3 cm.

14 . The implantable device of claim 12 , wherein the length of the implantable device is from about 0.5 cm to about 2 cm.

15 . The implantable device of claim 12 , wherein the length of the implantable device is from about 0.5 cm to about 1.5 cm.

16 . The implantable device of claim 12 , wherein the length of the implantable device is from about 0.5 cm to about 1 cm.

17 . The implantable device of claim 12 , wherein the length of the implantable device is from about 1 cm to about 3 cm.

18 . The implantable device of claim 12 , wherein the diameter of the implantable device is about 1 to about 3 mm in diameter.

19 . The implantable device of claim 12 , wherein the diameter of the implantable device is about 1 mm.

20 . The implantable device of claim 1 , wherein the porous outer shell further comprises a porogen material adapted to dissolve or dissociate therefrom.

21 . The implantable device of claim 12 , wherein the porous outer shell further comprises a porogen material adapted to dissolve or dissociate therefrom.

Continuity (4)
Continuation 18076023 · Dec 6, 2022
Continuation 16338962 · Oct 5, 2017
Provisional Application 62404643 · Oct 5, 2016
Related Publication 20230301902A1 · Sep 28, 2023
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