Acyclic thiol prodrugs
Disclosed herein are acyclic thiol prodrugs, and pharmaceutical compositions thereof. The prodrugs and pharmaceutical compositions thereof may be used to treat or prevent medical disorders such as, for example cystinosis, cystinuria, cancer neurodegenerative disease, Parkinson's disease, Huntington's disease, malaria, nonalcoholic fatty liver disease, radiation poisoning, arsenic poisoning, radioprotection, Wilson's disease or rheumatoid arthritis.
1. A compound of structural formula:
and pharmaceutically acceptable salts, hydrates or solvates thereof.
2. A compound of structural formula:
and pharmaceutically acceptable salts, hydrates or solvates thereof.
3. A compound of structural formula:
and pharmaceutically acceptable salts, hydrates or solvates thereof.
4. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable vehicle.
5. A pharmaceutical composition comprising the compound of claim 2 and a pharmaceutically acceptable vehicle.
6. A pharmaceutical composition comprising the compound of claim 3 and a pharmaceutically acceptable vehicle.