IP Library Granted Patent US 12,691,179
Granted Patent B2
US 12,691,179 · App. 18/149,414 · Granted Jul 28, 2026

Somatostatin receptor-based cancer therapy

Inventor: Vikas Kundra (Bethesda, MD)
Assignee: Vikas Kundra
A61K47/46A61K35/28A61K38/179A61K38/31A61K47/6425A61K47/6901A61K51/00A61K51/083A61K51/088C07K14/71C12N15/88
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Quick Facts
Patent No.
US 12,691,179
App. No.
18/149,414
Granted
Jul 28, 2026
Kind
B2
Abstract

Methods and composition for cell-based therapy as well as somatostatin receptor-based therapy are described. For example, in certain aspects methods for administering an anti-tumor therapy using a signaling defective somatostatin receptor mutant are described. Furthermore, the invention provides compositions and methods involve a somatostatin constitutively active somatostatin receptor mutant.

Claims (8)

1 . A constitutively active somatostatin receptor type 2 (SSTR2) mutant, wherein the mutant is a C-terminal deletion mutant of a human somatostatin receptor, wherein mutant is SSTR2 delta 340 mutant with the sequence of amino acids 1-340 of SEQ ID NO:6.

2 . A therapeutic composition comprising the mutant of claim 1 and a pharmaceutically acceptable carrier.

3 . A nucleic acid molecule comprising a constitutively active somatostatin receptor (SSTR2) mutant of a human somatostatin receptor, having a nucleotide sequence that encodes the amino acids 1-340 of SEQ ID NO: 6.

4 . A therapeutic composition comprising the nucleic acid of claim 3 , and a pharmaceutically acceptable carrier.

5 . An expression construct comprising the nucleic acid molecule of claim 3 .

6 . A therapeutic composition comprising the expression construct of claim 5 , and a pharmaceutically acceptable carrier.

7 . The expression construct of claim 5 , wherein the nucleic acid further comprises a second coding sequence.

8 . The expression construct of claim 7 , wherein the second coding sequence is a protein tag gene, a reporter gene, a therapeutic gene, a signaling sequence, or a trafficking sequence.

Continuity (5)
Division 16659986 · Oct 22, 2019
Division 15647840 · Jul 12, 2017
Division 13821541 · Sep 8, 2011
Provisional Application 61380920 · Sep 8, 2010
Related Publication 20230218764A1 · Jul 13, 2023
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