IP Library Granted Patent US 11,893,510
Granted Patent B2
US 11,893,510 · App. 18/149,969 · Granted Feb 6, 2024

Systems and methods for processing images to classify the processed images for digital pathology

Inventors: Supriya Kapur (New York, NY); Christopher Kanan (Pittsford, NY); Thomas Fuchs (New York, NY); Leo Grady (Darien, CT)
Assignee: Paige.AI, Inc.
G06N5/04G06N20/00G06T7/0012G06T2207/20076G06T2207/20081G06T2207/30168
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Quick Facts
Patent No.
US 11,893,510
App. No.
18/149,969
Granted
Feb 6, 2024
Kind
B2
Abstract

Systems and methods are disclosed for receiving a target image corresponding to a target specimen, the target specimen comprising a tissue sample of a patient, applying a machine learning model to the target image to determine at least one characteristic of the target specimen and/or at least one characteristic of the target image, the machine learning model having been generated by processing a plurality of training images to predict at least one characteristic, the training images comprising images of human tissue and/or images that are algorithmically generated, and outputting the at least one characteristic of the target specimen and/or the at least one characteristic of the target image.

Claims (54)

1. A computer-implemented method for analyzing an image corresponding to a specimen, the method comprising:

receiving a target image corresponding to a target specimen, the target specimen comprising a tissue sample of a patient;

applying a machine learning model to the target image to determine at least one characteristic of the target specimen and/or at least one characteristic of the target image, the machine learning model having been generated by processing a plurality of training images to identify a presence of one or more treatment effects and predict at least one characteristic, the training images comprising images of human tissue and/or images that are algorithmically generated;

upon identifying the presence of the one or more treatment effects, predicting the one or more treatment effects; and

providing the at least one characteristic of the target specimen and/or the at least one characteristic of the target image for storage and/or display.

2. The computer-implemented method of claim 1 , further comprising:

applying a trained machine learning model to the target image to determine a degree of treatment effects; and

outputting an indication of a degree to which the tissue sample of the patient has been treated.

3. The computer-implemented method of claim 2 , further comprising:

upon determining the target image being classified as treated, outputting a degree of treatment effects associated with the treated target image.

4. The computer-implemented method of claim 1 , wherein the trained machine learning model is trained by:

receiving, as training data, a plurality of training images and one or more treatment effect labels corresponding to each training image of the plurality of training images; and

training a machine learning model, using the training data, to infer one or more of whether a target image contains a treatment effect or a degree of treatment effects.

5. The computer-implemented method of claim 4 , wherein the plurality of training images comprise a plurality of digital pathology images that include images of tissues that have treatment effects and images of tissues that do not have treatment effects.

6. The computer-implemented method of claim 1 , wherein the presence of one or more treatment effects includes one or more prior treatments associated with the tissue sample of the patient.

7. The computer-implemented method of claim 1 , further comprising:

appending a label to the target image, the label indicating the presence of the one or more treatment effects for the target image.

8. The computer-implemented method of claim 7 , further comprising:

providing the target image and appended label to a digital storage system.

9. A system for analyzing an image corresponding to a specimen, the system comprising:

at least one memory storing instructions; and

at least one processor executing the instructions to perform operations comprising a process including:

receiving a target image corresponding to a target specimen, the target specimen comprising a tissue sample of a patient;

applying a machine learning model to the target image to determine at least one characteristic of the target specimen and/or at least one characteristic of the target image, the machine learning model having been generated by processing a plurality of training images to predict a presence of one or more treatment effects and predict at least one characteristic, the training images comprising images of human tissue and/or images that are algorithmically generated;

upon identifying the presence of the one or more treatment effects, predicting the one or more treatment effects; and

providing the at least one characteristic of the target specimen and/or the at least one characteristic of the target image for storage and/or display.

10. The system of claim 9 , further comprising:

applying a trained machine learning model to the target image to determine a degree of treatment effects; and

outputting an indication of a degree to which the tissue sample of the patient has been treated.

11. The system of claim 10 , further comprising:

upon determining the target image being classified as treated, outputting a degree of treatment effects associated with the treated target image.

12. The system of claim 9 , wherein the trained machine learning model is trained by:

receiving, as training data, a plurality of training images and one or more treatment effect labels corresponding to each training image of the plurality of training images; and

training a machine learning model, using the training data, to infer one or more of whether a target image contains a treatment effect or a degree of treatment effects.

13. The system of claim 12 , wherein the plurality of training images comprise a plurality of digital pathology images that include images of tissues that have treatment effects and images of tissues that do not have treatment effects.

14. The system of claim 9 , wherein the presence of one or more treatment effects includes one or more prior treatments associated with the tissue sample of the patient.

15. The system of claim 9 , further comprising:

appending a label to the target image, the label indicating the presence of the one or more treatment effects for the target image.

16. The system of claim 15 , further comprising:

providing the target image and appended label to a digital storage system.

17. A computer-implemented method for analyzing an image corresponding to a specimen, the method comprising:

receiving a target image corresponding to a target specimen, the target specimen comprising a tissue sample of a patient;

applying a machine learning model to the target image to determine at least one characteristic of the target specimen and/or at least one characteristic of the target image, the machine learning model having been generated by processing a plurality of training images to predict a degree of treatment effects based on a determined presence of one or more treatment effects, and/or to predict at least one characteristic, the training images comprising images of human tissue and/or images that are algorithmically generated;

in response to classifying the tissue sample as treated, predicting the degree of treatment effects; and

providing the at least one characteristic of the target specimen and/or the at least one characteristic of the target image for storage and/or display.

18. The computer-implemented method of claim 17 , wherein the trained machine learning model is trained by:

receiving, as training data, a plurality of training images, the plurality of training images comprising a plurality of digital pathology images that include images of tissues that have treatment effects and images of tissues that do not have treatment effects;

receiving, as training data, one or more treatment effect labels corresponding to each training image of the plurality of training images; and

training a machine learning model, using the training data, to infer a degree of treatment effects.

19. The computer-implemented method of claim 17 , further comprising:

determining one or more morphological changes to the tissue sample based on the determined treatment effect.

20. The computer-implemented method of claim 17 , further comprising:

appending a label to the target image, the label indicating the presence of the one or more treatment effects for the target image; and

providing the target image and appended label to a digital storage system.

Assignments (3)
RELEASE OF SECURITY INTEREST Recorded May 14, 2026
From: ARES CAPITAL CORPORATION, AS COLLATERAL AGENT
To: PAIGE.AI, INC.
Reel/Frame 075589/0752 →
SECURITY INTEREST Recorded Oct 21, 2025
From: PAIGE.AI, INC.
To: ARES CAPITAL CORPORATION, AS COLLATERAL AGENT
Reel/Frame 073216/0876 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 9, 2023
From: KAPUR, SUPRIYA; KANAN, CHRISTOPHER; FUCHS, THOMAS; GRADY, LEO
To: PAIGE.AI, INC.
Reel/Frame 062306/0338 →
Continuity (6)
Continuation 17705908 · Mar 28, 2022
Continuation 17303164 · May 21, 2021
Continuation 17112435 · Dec 4, 2020
Continuation 16875616 · May 15, 2020
Provisional Application 62848703 · May 16, 2019
Related Publication 20230144137A1 · May 11, 2023