PHARMACEUTICAL COMPOSITIONS COMPRISING POH DERIVATIVES AND METHODS OF USE
The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of a perillyl alcohol derivative such as a perillyl alcohol ester, or an isoperillyl alcohol derivative such as an isoperillyl alcohol ester. The derivative may be a perillyl alcohol or an isoperillyl alcohol conjugated with a therapeutic agent such as valproic acid. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.
1 . A method for treating a disease in a mammal, the method comprising the step of administering to the mammal a therapeutically effective amount of a perillyl alcohol conjugated with valproic acid.
2 . The method of claim 1 , wherein the disease is cancer.
3 . The method of claim 2 , wherein the cancer is a tumor of the nervous system.
4 . The method of claim 3 , wherein the tumor is a glioblastoma.
5 . The method of claim 1 , further comprising the step of treating the mammal with radiation.
6 . The method of claim 1 , further comprising the step of administering to the mammal a chemotherapeutic agent.
7 . The method of claim 1 , wherein the perillyl alcohol conjugated with valproic acid is administered by inhalation, intranasally, orally, intravenously, subcutaneously or intramuscularly.
8 . A method for treating a disease in a mammal, comprising the step of administering to the mammal a therapeutically effective amount of a perillyl alcohol conjugated with valproic acid conjugated with valproic acid using a nasal delivery device.
9 . The method of claim 8 , wherein the nasal delivery device is selected from the group consisting of an intranasal inhaler, an intranasal spray device, an atomizer, a nebulizer, a metered dose inhaler (MDI), a pressurized dose inhaler, an insufflator, a unit dose container, a pump, a dropper, a squeeze bottle and a bi-directional device.