IP Library › Granted Patent US 12,329,737
Granted Patent B2
US 12,329,737 · App. 18/152,098 · Granted Jun 17, 2025

Patent

Inventors: Bill J. Baker (Temple Terrace, FL); Lindsey N. Shaw (Tampa, FL); Andrew Jason Shilling (Tampa, FL); Alexandre Jean Bory (Yvonand, CH); Jessie Allen (Adams) (Tampa, FL); Charles Dunkle Amsler, Jr. (Pelham, AL); James Bruce McClintock (Birmingham, AL)
A61K31/343A61K31/192A61K31/352A61K2236/39
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Quick Facts
Patent No.
US 12,329,737
App. No.
18/152,098
Granted
Jun 17, 2025
Kind
B2
Abstract

Described herein are Dendrilla membranosa compounds and derivatives thereof. Also described herein are formulations that can contain an amount of one or more Dendrilla membranosa compounds or derivatives thereof and a carrier. Also described herein are methods of administering one or more Dendrilla membranosa compound and/or derivative thereof or a formulation thereof to a subject in need thereof.

Claims (6)

1. A method of treating a biofilm in a subject or preventing the formation of a biofilm in a subject, the method comprising administering to the subject an effective amount of a compound having the formula:

2. The method of claim 1 , wherein the compound is administered to the subject as a unit dose composition comprising a pharmaceutically acceptable carrier.

3. The method of claim 1 , wherein the compound is administered to the subject at a dosage of from about 0.1 μg/kg to about 1,000 μg/kg per unit dose composition.

4. The method of claim 1 , wherein the compound has a MBEC 90 value less than or equal to 100 μg/ml against methicillin-resistant Staphylococcus aureus (MRSA).

5. The method of claim 1 , wherein the biofilm comprises methicillin-resistant Staphylococcus aureus (MRSA).

6. The method of claim 1 , wherein the biofilm comprises multi-drug resistant A. baumannii.

Assignments (1)
CONFIRMATORY LICENSE Recorded Feb 5, 2025
From: UNIVERSITY OF SOUTH FLORIDA
To: NATIONAL SCIENCE FOUNDATION
Reel/Frame 070112/0785 →
Continuity (3)
Continuation 16715447 · Dec 16, 2019
Provisional Application 62779944 · Dec 14, 2018
Related Publication 20230165830A1 · Jun 1, 2023
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