IP Library Granted Patent US 12,472,206
Granted Patent B2
US 12,472,206 · App. 18/153,124 · Granted Nov 18, 2025

Pharmaceutical composition containing cerium compound as active ingredient

Inventors: Tsunetaka Kawaguchi (Tokyo, JP); Masaharu Nakatsu (Tokyo, JP); Yukihiro Ogawa (Tokyo, JP); Akiko Hashimoto (Tokyo, JP)
Assignees: Applause Pharma Co., Ltd.; Mitsui Mining & Smelting Co., Ltd.
A61K33/244A61P13/12
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Quick Facts
Patent No.
US 12,472,206
App. No.
18/153,124
Granted
Nov 18, 2025
Kind
B2
Abstract

Primarily aimed at providing a novel pharmaceutical composition. The present invention relates to a pharmaceutical composition that contains a cerium compound as an active ingredient.

Claims (2)

1 . A method for treating kidney disease, comprising orally administering a composition comprising a cerium salt comprising a cerium (III) salt selected from the group consisting of cerium (III) chloride, cerium (III) acetate, cerium (III) nitrate, cerium (III) citrate, cerium (III) carbonate, and hydrates and mixtures thereof, to a subject in need of treatment of kidney disease, wherein the administering does not include administering the cerium salt together with cerium oxide.

2 . The method according to claim 1 , wherein an amount of the cerium salt is in a range from 0.001 to 100% by mass relative to a total mass of the composition.

Assignments (3)
CHANGE OF NAME Recorded Jan 7, 2026
From: MITSUI MINING & SMELTING CO., LTD.
To: MITSUI KINZOKU COMPANY, LIMITED
Reel/Frame 074258/0384 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 15, 2023
From: APPLAUSE PHARMA CO., LTD.
To: MITSUI MINING & SMELTING CO., LTD.
Reel/Frame 064591/0079 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 11, 2023
From: KAWAGUCHI, TSUNETAKA; NAKATSU, MASAHARU; OGAWA, YUKIHIRO; HASHIMOTO, AKIKO
To: APPLAUSE PHARMA CO., LTD.
Reel/Frame 062347/0348 →
Priority Claims (1)
JP 2020-119746 · Jul 13, 2020 · national
Continuity (2)
Continuation In Part PCTJP2021017295 · Apr 30, 2021
Related Publication 20230233603A1 · Jul 27, 2023
References Cited (29)
US 5968976A · Murrer et al. · 1999 [cited by applicant]
US 9669055B1 · Blough · 2017 [cited by examiner]
US 11806461B2 · Oishi et al. · 2023 [cited by applicant]
US 20060047086A1 · Albright · 2006 [cited by examiner]
US 20090074883A1 · Gupta · 2009 [cited by applicant]
US 20110123604A1 · Strickland · 2011 [cited by examiner]
US 20140271899A1 · Leiter et al. · 2014 [cited by applicant]
US 20160144005A1 · Bernachon · 2016 [cited by examiner]
US 20180325832A1 · Bell · 2018 [cited by applicant]
US 20180326141A1 · Han et al. · 2018 [cited by applicant]
US 20210353845A1 · Oishi et al. · 2021 [cited by applicant]
CN 109939125 · 2019 [cited by applicant]
JP 62011611 · 1987 [cited by applicant]
JP 08010610 · 1996 [cited by applicant]
JP 11503119 · 1999 [cited by applicant]
JP 2007022836 · 2007 [cited by applicant]
JP 2016514163 · 2016 [cited by applicant]
JP 2018508568 · 2018 [cited by applicant]
JP 2020045290 · 2020 [cited by applicant]
JP 2020045291 · 2020 [cited by applicant]
JP 6664631B · 2020 [cited by applicant]
TW 201945040 · 2019 [cited by applicant]
WO 2020086496 · 2020 [cited by applicant]
Extended European Search Report issued in corresponding European Patent Application No. 21842561.9, Jun. 12, 2024, 9 pages. [cited by applicant]
Ogura, Masahiro et al., “Development of non-aluminum phosphate binder. Hydrous cerium oxide—Hydrous cerium oxide”, Journal of Artificial Organs, 1986, vol. 15, No. 3, pp. 1205-1207—Abstract. [cited by applicant]
Ogura, Masahiro et al., “Development of non-aluminum phosphate binder—Hydrous cerium oxide”, Journal of the Japanese Society for Dialysis Therapy, 1986, vol. 19, No. 8, pp. 775-778—Abstract. [cited by applicant]
Saifi, M. A. et al. Protective Effect of Nanoceria on Cisplatin-induced Nephrotoxicity by Amelioration of Oxidative Stress and Pro-inflammatory Mechanisms. Biological Trace Element Research, 2019, vol. 189, pp. 145-156. [cited by applicant]
Miyakawa, Kazuki et al., “CeO2 nanoparticle hydrothermal synthesis with amino base for the production of nanocomposite materials”, Proceedings of the 2015 SCEJ 80th Annual Meeting, 2015, XC237, pp. 1. [cited by applicant]
Search Report issued in International Application No. PCT/JP2021/017295, Jun. 22, 2021, 3 pages. [cited by applicant]