IP Library › Granted Patent US 12,414,951
Granted Patent B2
US 12,414,951 · App. 18/156,095 · Granted Sep 16, 2025

Use of compound in preparation of medicament for prophylaxis and treatment of inflammatory tissue damage

Inventors: Shuyu Zhang (Chengdu, CN); Fenghao Geng (Chengdu, CN); Jianhui Chen (Chengdu, CN); Xiaoqian Li (Chengdu, CN)
Assignees: Sichuan University; Nuclear Industry 416 Hospital
A61K31/517A61P17/02A61P17/16A61P17/18A61P29/00A61P39/00
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Quick Facts
Patent No.
US 12,414,951
App. No.
18/156,095
Granted
Sep 16, 2025
Kind
B2
Abstract

The present disclosure relates to use of a compound in preparation of a medicament for prophylaxis and treatment of inflammatory tissue damage. The present disclosure provides use of a compound in preparation of a medicament for prophylaxis and treatment of tissue damage, and the compound has a structure represented by formula I. The compound having the structure represented by formula I provided by the present disclosure can inhibit transcriptional activity of interferon regulatory factor 1 (IRF1), have prophylactic and therapeutic effects on tissue damage, enhance cell proliferation ability after tissue cell injury, and repair injured tissues. The compound having the structure represented by formula I provided by the present disclosure has important significance and application value in the preparation of the medicament for prophylaxis and treatment of tissue damage, particularly in the preparation of a medicament for inflammatory injuries of skin tissues induced by radiation and/or oxidation.

Claims (2)

1. A method for treating ionizing radiation-induced skin injury in a subject, comprising administering to the subject a pharmaceutical composition comprising a compound and one or more pharmaceutical excipients, wherein the compound has the structure represented by formula I:

2. The method according to claim 1 , wherein the pharmaceutical composition is administered in a dosage form of an injection.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 2, 2025
From: WEST CHINA SECOND UNIVERSITY HOSPITAL, SICHUAN UNIVERSITY
To: SICHUAN UNIVERSITY
Reel/Frame 071285/0619 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 18, 2023
From: ZHANG, SHUYU; GENG, FENGHAO; CHEN, JIANHUI; LI, XIAOQIAN
To: WEST CHINA SECOND UNIVERSITY HOSPITAL, SICHUAN UNIVERSITY; NUCLEAR INDUSTRY 416 HOSPITAL
Reel/Frame 062420/0557 →
Priority Claims (1)
CN 202210839676.4 · Jul 18, 2022 · national
Continuity (1)
Related Publication 20240016806A1 · Jan 18, 2024
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