Granted Patent
B2
US 12,226,401 · App. 18/164,175 · Granted Feb 18, 2025
Molecular genetic approach to treatment and diagnosis of alcohol and drug dependence
Assignee:
University of Virginia Patent Foundation
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Abstract
Compositions and methods are provided that are useful for diagnosing, treating, and monitoring alcohol dependence and disorders, susceptibility to alcohol dependence disorders, as well as drug related dependence and disorders. The methods include treating patients with an antagonist of the serotonin receptor 5-HT3 for such disorders, wherein the patient's serotonin transporter gene SLC6A4 is known to have particular genotypes.
Claims (37)
1. A method of testing the genotypes of a patient having an addictive disease or disorder comprising:
obtaining a biological sample from the patient;
testing the biological sample from the patient to detect the presence of genotypes (a)-(b):
(a) the AC genotype of rs17614942 of gene HTR3B; and,
(b) the AG genotype of rs1150226 of gene HTR3A;
wherein the addictive disease or disorder is an alcohol-related disease or disorder or an opioid-related disorder.
2. The method of claim 1 , wherein the genotypes, comprise:
(a) the AC genotype of rs17614942 of gene HTR3B;
(b) the AG genotype of rs1150226 of gene HTR3A; and,
(c) the LL genotype of the functional polymorphism serotonin transporter-linked polymorphic region 5-HTTLPR of gene SLC6A4.
3. The method of claim 1 , wherein the genotypes, comprise:
(a) the AC genotype of rs17614942 of gene HTR3B;
(b) the AG genotype of rs1150226 of gene HTR3A; and,
(c) the TT genotype of rs1042173 of gene SLC6A4.
4. The method of claim 1 , wherein the genotypes, comprise:
(a) the AC genotype of rs17614942 of gene HTR3B;
(b) the AG genotype of rs1150226 of gene HTR3A;
(c) the LL genotype of the functional polymorphism serotonin transporter-linked polymorphic region 5-HTTLPR of gene SLC6A4; and,
(d) the TT genotype of rs1042173 of gene SLC6A4.
5. The method of claim 1 , further comprising:
administering to the patient a therapeutically effective amount of ondansetron, if one of the genotypes assayed is detected.
6. The method of claim 5 , wherein ondansetron is administered at a dosage ranging from 0.1 μg/kg to 1000 μg/kg per application.
7. The method of claim 5 , wherein ondansetron is administered at a dosage of 1 μg/kg to 30 μg/kg per application.
8. The method of claim 5 , wherein ondansetron is administered at a dosage of 1 μg/kg per application.
9. The method of claim 5 , wherein ondansetron is administered at a dosage of 2 μg/kg per application.
10. The method of claim 5 , wherein ondansetron is administered at a dosage of 3 μg/kg per application.
11. The method of claim 5 , wherein ondansetron is administered at a dosage of 4 μg/kg per application.
12. The method of claim 5 , wherein ondansetron is administered at a dosage of 5 μg/kg per application.
13. The method of claim 5 , wherein ondansetron is administered at a dosage of 6 μg/kg per application.
14. The method of claim 5 , wherein ondansetron is administered at a dosage of 7 μg/kg per application.
15. The method of claim 5 , wherein ondansetron is administered at a dosage of 8 μg/kg per application.
16. The method of claim 5 , wherein ondansetron is administered at a dosage of 9 μg/kg per application.
17. The method of claim 5 , wherein ondansetron is administered at a dosage of 10 μg/kg per application.
18. The method of claim 5 , wherein the addictive disease or disorder is an alcohol-related disease or disorder.
19. The method of claim 18 , wherein the alcohol-related disease or disorder is selected from the group consisting of: early onset alcoholism, late onset alcoholism, alcohol-induced psychotic disorder with delusions, alcohol abuse, heavy drinking, excessive drinking, alcohol intoxication, alcohol withdrawal, alcohol intoxication delirium, alcohol withdrawal delirium, alcohol-induced persisting dementia, alcohol-induced persisting amnestic disorder, alcohol dependence, alcohol-induced psychotic disorder with hallucinations, alcohol-induced mood disorder, alcohol-induced or associated bipolar disorder, alcohol-induced or associated post-traumatic stress disorder, alcohol-induced anxiety disorder, alcohol-induced sexual dysfunction, alcohol-induced sleep disorder, alcohol-induced or associated gambling disorder, alcohol-induced or associated sexual disorder, alcohol-related disorder not otherwise specified, alcohol intoxication, and alcohol withdrawal.
20. The method of claim 5 , wherein the addictive disease or disorder is an opioid-related disorder.
21. The method of claim 20 , wherein the opioid-related disorder is selected from the group consisting of: opioid dependence, opioid abuse, opioid intoxication, opioid intoxication delirium, opioid-induced psychotic disorder, with delusions, opioid-induced psychotic disorder with hallucinations, opioid-induced anxiety disorder, opioid-related disorder not otherwise specified (nos), opioid intoxication, and opioid withdrawal.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Feb 3, 2023
From: JOHNSON, BANKOLE A.
To: UNIVERSITY OF VIRGINIA
Reel/Frame 062586/0443 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Feb 3, 2023
From: UNIVERSITY OF VIRGINIA
To: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
Reel/Frame 062586/0538 →
Continuity (10)
Continuation
PCTUS2011042823
· Jul 1, 2011
Provisional Application
61488328
· May 20, 2011
Provisional Application
61429416
· Jan 3, 2011
Provisional Application
61361203
· Jul 2, 2010
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