IP Library › Patent Application 18168495
Patent Application
App. No. 18/168,495

CO-CRYSTAL FORMS OF A NOVOBIOCIN ANALOG AND PROLINE

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Quick Facts
Patent No.
US None
App. No.
18/168,495
Abstract

Disclosed are co-crystal forms of N-(2-(5-(((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetra-hydro-2H-pyran-2-yl)oxy)-3′-fluoro-[1,1′-biphenyl]-2-yl)ethyl)-acetamide and L-proline or D-proline, their pharmaceutical compositions, processes of manufacture, and methods of use for treating neurodegenerative disorders such as diabetic peripheral neuropathy.

Claims (1)

1 . A co-crystal of N-(2-(5-(((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetra-hydro-2H-pyran-2-yl)oxy)-3′-fluoro-[1,1′-biphenyl]-2-yl)ethyl)-acetamide and L-proline (1:2), characterized by an X-ray powder diffractogram comprising the following peaks: 14.76, 16.86, 19.00, and 21.05° 2θ±0.20° 2θ as determined on a diffractometer using Cu-Kα radiation at a wavelength of 1.54178 Å.

Assignments (7)
RELEASE OF SECURITY INTEREST Recorded Apr 9, 2025
From: BIOPHARMA CREDIT PLC
To: REATA PHARMACEUTICALS HOLDINGS, LLC; REATA PHARMACEUTICALS GLOBAL, INC.; REATA PHARMACEUTICALS, INC.
Reel/Frame 070793/0228 →
RELEASE OF SECURITY INTEREST Recorded Apr 9, 2025
From: BIOPHARMA CREDIT PLC
To: REATA PHARMACEUTICALS HOLDINGS, LLC; REATA PHARMACEUTICALS GLOBAL, INC.; REATA PHARMACEUTICALS, INC.
Reel/Frame 070793/0130 →
AMENDED AND RESTATED PATENT SECURITY AGREEMENT Recorded Jul 12, 2023
From: REATA PHARMACEUTICALS HOLDINGS, LLC; REATA PHARMACEUTICALS GLOBAL, INC.; REATA PHARMACEUTICALS, INC.
To: BIOPHARMA CREDIT PLC
Reel/Frame 064264/0557 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 23, 2023
From: BEVILL, MELANIE J; SEADEEK, CHRISTOPHER S; SMIT, JARED P
To: ALBANY MOLECULAR RESEARCH, INCORPORATED
Reel/Frame 063729/0976 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 23, 2023
From: ALBANY MOLECULAR RESEARCH, INCORPORATED
To: REATA PHARMACEUTICALS, INC.
Reel/Frame 063730/0093 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 23, 2023
From: JIANG, XIN; WALLING, JOHN ALLEN
To: REATA PHARMACEUTICALS, INC.
Reel/Frame 063729/0726 →
PATENT SECURITY AGREEMENT Recorded May 18, 2023
From: REATA PHARMACEUTICALS HOLDINGS, LLC; REATA PHARMACEUTICALS GLOBAL, INC.; REATA PHARMACEUTICALS, INC.
To: BIOPHARMA CREDIT PLC
Reel/Frame 063697/0461 →