Granted Patent B2

US 12,465,413 · App. 18/171,696 · Granted Nov 11, 2025

Inventors: Mark Hunter (St. Louis, MO); Troy L. Holsing (Golden, CO)

Assignee: Veran Medical Technologies, Inc.

A61B18/02A61B8/12A61B18/1492A61B90/37A61B2018/00583A61B2018/00702A61B2018/00791A61B2018/0212A61B2090/378

Abstract

Claims (42)

1 . A method for treating a patient comprising:

a) inserting a cryoprobe within an introducer canula into targeted tissue in the patient;

b) generating an ice ball by cooling the cryoprobe;

c) removing the cryoprobe from the introducer canula and inserting an ultrasound catheter within the introducer canula; and

d) using the ultrasound catheter to determine a distance between the ultrasound catheter and a periphery of the ice ball by generating ultrasound energy within the ice ball.

2 . The method of claim 1 , wherein the ultrasound energy within the ice ball is generated by transmitting, from the ultrasound catheter, a plurality of directional ultrasound pulses within the ice ball radially away from the ultrasound catheter.

3 . The method of claim 2 , wherein the distance between the ultrasound catheter and the periphery of the ice ball is determined by using a time between the transmitting and a receiving of each pulse, and by using a known speed of ultrasound transmission in the ice ball.

4 . The method of claim 2 , wherein the plurality of directional ultrasound pulses are transmitted from a plurality of different translational positions by physically moving the ultrasound catheter between the plurality of different translational positions.

5 . The method of claim 4 , wherein a model of a slice of the ice ball is calculated at each of the plurality of different translational positions.

6 . The method of claim 5 , further comprising using a computer to combine the slices into an ice ball model showing a size and a shape for at least a portion of the ice ball.

7 . The method of claim 2 , wherein an ice ball model is created by a computer using determined distances from the plurality of directional ultrasound pulses, further comprising using the computer to compare the ice ball model against a known size and shape for the targeted tissue to identify portions of the targeted tissue outside an effective treatment area for the ice ball.

8 . The method of claim 2 , wherein the ultrasound catheter is physically rotated to transmit the plurality of directional ultrasound pulses.

9 . The method of claim 2 , wherein the ultrasound catheter has a plurality of ultrasound transducer elements near a distal end of the ultrasound catheter; further wherein each ultrasound transducer element of the plurality of ultrasound transducer elements is of a type selected from a set consisting of PZT based-transducers, pMUT based-transducers, and cMUT based-transducers.

10 . The method of claim 9 , wherein a particular directional ultrasound pulse in the plurality of directional ultrasound pulses is created using a phased-array in which the plurality of ultrasound transducer elements work together to form a directional beam of ultrasonic energy in a single direction.

11 . The method of claim 10 , wherein the plurality of ultrasound transducer elements that work together to form the directional beam of ultrasonic energy in the single direction also receive energy previously transmitted by the particular directional ultrasound pulse, wherein the received energy is analyzed to maximize a signal received by the plurality of ultrasound transducer elements from the single direction.

12 . The method of claim 1 , wherein using the ultrasound catheter to determine the distance includes generating a model of an ice ball that has been formed within the patient, the generating the model comprising:

a) positioning the ultrasound catheter into an interior of the ice ball;

b) transmitting, from the ultrasound catheter, a plurality of directional ultrasound pulses within the ice ball radially away from the ultrasound catheter, wherein the plurality of directional ultrasound pulses:

i) are transmitted in a plurality of radial directions, and

ii) are transmitted from a plurality of different translational positions;

c) determining, using a computer, a plurality of distances from the ultrasound catheter to an edge of the ice ball by using a time between a transmission and a receiving of each ultrasound pulse and by using a known speed of ultrasound transmission in the ice ball; and

d) creating, using the computer, the model of the ice ball using the plurality of distances based on the radial direction and the translational position for each ultrasound pulse.

13 . The method of claim 12 , further comprising:

e) displaying, using the computer, the model of the ice ball on a three-dimensional image of the patient showing an area of targeted tissue.

14 . The method of claim 13 , further comprising:

f) comparing on the computer the model of the ice ball against a known size and shape for the area of the targeted tissue to identify portions of the targeted tissue outside an effective treatment area for the area of ablated tissue; and

g) displaying the identified portions of the targeted tissue using an identifiable distinguishing visual characteristic.

15 . The method of claim 14 , wherein a distal end of the ultrasound catheter further contains electromagnetic sensors that receive electromagnetic signals that locate the distal end in an electromagnetic field, and further comprising using the received electromagnetic signals to display the model of the ice ball on the three-dimensional image of the patient.

16 . The method of claim 12 , wherein the ultrasound catheter has a plurality of ultrasound transducers at a distal end, further wherein a subset less than all of the plurality of ultrasound transducers are used to produce each ultrasound pulse, further wherein the subset is chosen based on a particular radial direction of each ultrasound pulse.

17 . The method of claim 16 , wherein the plurality of ultrasound transducers are PZT based-transducers.

18 . The method of claim 16 , wherein the plurality of ultrasound transducers are pMUT based-transducers.

19 . The method of claim 16 , wherein the plurality of ultrasound transducers are cMUT based-transducers.

20 . The method of claim 1 , using the ultrasound catheter to determine the distance includes generating a model of an area of ablated tissue that has been formed within the patient, the generating the model comprising:

a) positioning the ultrasound catheter into an interior of the area of the ablated tissue;

b) transmitting, from the ultrasound catheter, a plurality of directional ultrasound pulses within the area of the ablated tissue radially away from the ultrasound catheter, wherein the plurality of directional ultrasound pulses:

i) are transmitted in a plurality of radial directions, and

ii) are transmitted from a plurality of different translational positions;

c) determining, using a computer, a plurality of distances from the ultrasound catheter to an edge of the area of the ablated tissue by using a time between a transmission and a receiving of each ultrasound pulse and by using a known speed of ultrasound transmission in the area of the ablated tissue;

d) creating, using the computer, the model of the area of the ablated tissue using the plurality of distances based on the radial direction and the translational position for each ultrasound pulse;

e) displaying, using the computer, the model of the area of the ablated tissue on a three-dimensional image of the patient showing an area of targeted tissue;

f) comparing on the computer the model of the area of the ablated tissue against a known size and shape for the area of the targeted tissue to identify portions of the targeted tissue outside an effective treatment area for the area of the ablated tissue; and

g) displaying the identified portions of the targeted tissue using an identifiable distinguishing visual characteristic.

Assignments (1)

Continuity (2)

References Cited (58)