FORMULATION FOR THE TREATMENT OF FINE LINES AND WRINKLES AND USES THEREOF
Disclosed herein are cosmetic compositions comprising Swertia chirata extract, hyaluronic acid, and retinoid, and a method of reducing fine lines and/or wrinkles, and/or smoothing the skin by topically applying the cosmetic compositions to the skin.
1 . A cosmetic composition comprising Swertia chirata extract, hyaluronic acid, and retinoid.
2 . The cosmetic composition of claim 1 , wherein the composition comprises about 0.005 wt. % to about 0.500 wt. % Swertia chirata extract.
3 . The cosmetic composition of claim 1 , wherein the composition comprises about 0.005 wt. % to about 1.00 wt. % retinoid.
4 . The cosmetic composition of claim 1 , wherein the composition comprises about 0.001 wt. % to about 2.0 wt. % hyaluronic acid.
5 . The cosmetic composition of claim 1 , wherein the composition comprises about 0.005 wt. % to about 0.500 wt. % Swertia chirata extract; about 0.005 wt. % to about 1.00 wt. % retinoid; and about 0.001 wt. % to about 2.0 wt. % hyaluronic acid.
6 . The cosmetic composition of claim 1 , wherein the composition comprises about 0.030 wt. % Swertia chirata extract; about 0.070 wt. % retinoid; and about 0.050 wt. % hyaluronic acid.
7 . The cosmetic composition of claim 1 , wherein the composition comprises about 0.030 wt. % Swertia chirata extract; about 0.110 wt. % retinoid; and about 0.002 wt. % hyaluronic acid.
8 . The cosmetic composition of claim 1 , wherein the retinoid is selected from the group consisting of retinol, retinal, tretinoin, isotretinoin, alitretinoin, etretinate acitretin, adapalene, bexarotene, and tazarotene, and trifarotene.
9 . The cosmetic composition of claim 8 , wherein the retinoid is retinol.
10 . The cosmetic composition claim 1 , wherein the hyaluronic acid comprises a mixture of hyaluronic acids of different molecular weights.
11 . The cosmetic composition of claim 10 , wherein the mixture comprises at least three hyaluronic acids of different molecular weights.
12 . The cosmetic composition of claim 1 , further comprising a vitamin C compound.
13 . The cosmetic composition of claim 12 , wherein the vitamin C compound comprises ascorbic acid or 3-O-ethyl ascorbic acid.
14 . The cosmetic composition of claim 1 , further comprising a chromenone of formula (I):
or a salt thereof; wherein:
R 1 and R 2 are identical or different, and are selected from the group consisting of H, —(C═O)—R 7 , —C(═O)—OR 7 , a straight-chain or branched C 1 - to C 20 -alkyl group, wherein the alkyl is optionally at least once interrupted by oxygen, a straight-chain or branched C 3 - to C 20 -alkenyl group, a straight-chain or branched to C 20 -hydroxyalkyl or di- or polyhydroxyalkyl group, where the hydroxyl group is bonded to a primary or secondary carbon atom of the alkyl, and wherein the alkyl is optionally at least once interrupted by oxygen, a C 3 - to C 10 -cycloalkyl group and a C 3 - to C 12 -cycloalkenyl group (where the cyclic group is optionally bridged by —CH 2 ) n — group where n=1 to 3);
R 3 is H or a straight-chain or branched C 1 - to C 20 -alkyl group;
R 4 is H or —OR 8 ;
R 5 and R 6 are identical or different, and are selected from the group consisting of H or —OH, a straight-chain or branched C 1 - to C 20 -alkyl group (wherein the alkyl is optionally at least once interrupted by oxygen), a straight-chain or branched C 3 - to C 20 -alkenyl group, and a straight-chain or branched C 1 - to C 20 -hydroxyalkyl group, where the hydroxyl group is bonded to a primary or secondary carbon atom of the alkyl, and wherein the alkyl is optionally at least once interrupted by oxygen;
R 7 is selected from the group consisting of H, a straight-chain or branched C 1 - to C 20 -alkyl group, wherein the alkyl is optionally at least once interrupted by oxygen, a straight-chain or branched C 3 - to C 20 -alkenyl group, and a straight-chain or branched C 1 - to C 20 -hydroxy-alkyl or -di- or polyhydroxyalkyl group, where the hydroxyl group is bonded to a primary or secondary carbon atom of the alkyl and wherein the alkyl is optionally at least once interrupted by oxygen; and
R 8 is H or a straight-chain or branched C 1 - to C 20 -alkyl group.
15 . The cosmetic composition of claim 14 , wherein the cosmetic composition comprises about 0.1 wt. % to about 2.0 wt. % of a compound of formula (I).
16 . The cosmetic composition of claim 14 , wherein the compound of formula (I) is dihydroxy methylchromenone.
17 . The cosmetic composition of claim 1 , wherein the cosmetic composition comprises at least 60 wt. % water.
18 . The cosmetic composition of claim 1 , wherein the cosmetic composition is a cream or a serum.
19 . A method of reducing fine lines and/or wrinkles, and/or smoothing the skin, comprising topically administering to the skin the cosmetic composition of claim 1 .
20 . The method of claim 19 , wherein the skin is the skin of the face and/or neck.
21 . The method of claim 19 , wherein the cosmetic composition is applied to the forehead, the lip, between the brows, under the eyes, the nasolabial folds, crow's feet, or a combination thereof.
22 . The method of claim 19 , wherein the skin is cleansed skin.
23 . The method of claim 19 , wherein the cosmetic composition is applied in the morning, the evening, or both.