Derivatives of aryl hydrocarbon receptor agonists

1. A compound having one of the following structures of Formula (IV) or (V):

or a stereoisomer, salt, or tautomer thereof, wherein:

R 1 , R 2 , R 3 , R 4 , R 5 R 6 , R 7 , and R 8 , are each independently hydrogen, deuterium, alkyl, halo, perfluoroalkyl, alkynyl, alkenyl, alkoxy, cycloalkoxy, thioalkyl, thiocycloalkoxy, perfluoroalkoxy, perfluorothioalkyl, hydroxyl, ester, amido, carboxyl, carbamoyl, sulfonyl amido, acylsulfonyl amido, sulfonyl, sulfinyl, sulfonyl urea, amino, thioester, nitrile, nitro, azido, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl

R 11a is halo, 4-8 membered heterocycloalkyl, 5-8 membered heteroaryl, —OH, —OX—, —SX—, —S(O) 2 X—, —NX 2 —, —OC(═O)X—, or —OC(═O)NX 2 —;

R 11b is 4-8 membered heterocycloalkyl, 5-8 membered heteroaryl, or —NX 2 —, wherein the 4-8 membered heterocycloalkyl of R 11a or R 11b is optionally substituted;

X is each independently hydrogen, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 1 -C 6 haloalkyl, C 1 -C 10 heteroalkyl, —S(O) 2 OH, aryl, or 3-8 membered heterocycloalkyl,

wherein the C 1 -C 10 alkyl and C 1 -C 10 heteroalkyl are optionally substituted with carboxyl, —NHS(═O) 2 Y—, —NHC(═O)OY—, or —NHC(═O)Y—;

wherein the 3-8 membered heterocycloalkyl of X is optionally substituted with C 1 -C 6 alkyl, C 1 -C 4 amino, halo, —C(═O)Y—, or —C(═O)OY—;

Y is each independently H, C 1 -C 6 perfluoroalkyl, or C 1 -C 6 alkyl;

R 12a and R 12b , are each independently hydrogen or C 1 -C 6 alkyl;

R 10 is O, NZ, or NNZ 2 ; and

Z is each independently hydrogen, hydroxyl, aryl, or C 1 -C 4 alkyl, wherein C 1 -C 4 alkyl is optionally substituted with aryl.

2. The compound of claim 1 , wherein the 4-8 membered heterocycloalkyl of R 11a or R 11b is azetidinyl, diazetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidinyl, piperidinyl, diazinyl, triazinyl, azepanyl, diazepanyl, azocanyl, oxetanyl, dioxetanyl, tetrahydrofuranyl, dioxolanyl, oxanyl, dioxanyl, trioxanyl, oxepanyl, oxocanyl, phosphetanyl, phospholanyl, phosphinanyl, thietanyl, dithietanyl, tetrahydrothiophenyl, dithiolanyl, thianyl, dithianyl, trithianyl, thiepanyl, thiocanyl, oxathiolidinyl, isoxthiolidinyl, oxazolidinyl, isoxazolidinyl, thiazolidinyl, isothiazolidinyl, morpholinyl, thiomorpholinyl, or oxathianyl.

3. The compound of claim 1 , wherein the 5-8 membered heteroaryl of R 11a or R 11b is pyrrole, furan, thiophene, pyridine, azonine, imidazole, pyrazole, oxazole, isoxazole, thiazole, isothiazole, diazine, triazine, tetrazine, pentazine, or diazepine.

4. The compound of claim 1 , wherein R 11a has one of the following structures:

5. The compound of claim 1 , wherein R 11b is —NX 2 —.

6. The compound of claim 5 , wherein R 11b has one of the following structures:

7. The compound of claim 1 , wherein each of R 12a and R 12b are hydrogen.

8. The compound of claim 1 , wherein R 10 has one of the following structures:

9. The compound of claim 1 , wherein R 1 , R 2 , R 3 , R 4 , R 5 R 6 , R 7 , and R 8 , are each independently hydrogen, deuterium, alkyl, halo, or perfluoroalkyl.

10. The compound of claim 1 , wherein the compound is selected from the group consisting of:

11. A compound having one of the following structures of Formula (IVa) or (Va):

or a stereoisomer, salt, or tautomer thereof, wherein:

R 11a is halo, 4-8 membered heterocycloalkyl, 5-8 membered heteroaryl, —OH, —OX—, —SX—, —S(O) 2 X—, —NX 2 —, —OC(═O)X—, or —OC(═O)NX 2 —;

R 11b is 4-8 membered heterocycloalkyl, 5-8 membered heteroaryl, or —NX 2 —, wherein the 4-8 membered heterocycloalkyl of R 11a or R 11b is optionally substituted;

X is each independently hydrogen, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 1 -C 6 haloalkyl, C 1 -C 10 heteroalkyl, —S(O) 2 OH, aryl, or 3-8 membered heterocycloalkyl,

wherein the C 1 -C 10 alkyl and C 1 -C 10 heteroalkyl are optionally substituted with carboxyl, —NHS(═O) 2 Y—, —NHC(═O)OY—, or —NHC(═O)Y—;

wherein the 3-8 membered heterocycloalkyl of X is optionally substituted with C 1 -C 6 alkyl, C 1 -C 4 amino, halo, —C(═O)Y—, or —C(═O)OY—;

Y is each independently H, C 1 -C 6 perfluoroalkyl, or C 1 -C 6 alkyl;

R 10 is O, NZ, or NNZ 2 ; and

Z is each independently hydrogen, hydroxyl, aryl, or C 1 -C 4 alkyl, wherein C 1 -C 4 alkyl is optionally substituted with aryl.

12. The compound of claim 11 , wherein the compound has one of the following structures of Formula (IVb) or (Vb):

or a stereoisomer, salt, or tautomer thereof.

13. The compound of claim 12 , wherein R 11a is 4-8 membered heterocycloalkyl or 5-8 membered heteroaryl.

14. The compound of claim 13 , wherein the 4-8 membered heterocycloalkyl of R 11a is azetidinyl, diazetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidinyl, piperidinyl, diazinyl, triazinyl, azepanyl, diazepanyl, azocanyl, oxetanyl, dioxetanyl, tetrahydrofuranyl, dioxolanyl, oxanyl, dioxanyl, trioxanyl, oxepanyl, oxocanyl, phosphetanyl, phospholanyl, phosphinanyl, thietanyl, dithietanyl, tetrahydrothiophenyl, dithiolanyl, thianyl, dithianyl, trithianyl, thiepanyl, thiocanyl, oxathiolidinyl, isoxthiolidinyl, oxazolidinyl, isoxazolidinyl, thiazolidinyl, isothiazolidinyl, morpholinyl, thiomorpholinyl, or oxathianyl.

15. The compound of claim 13 , wherein the 5-8 membered heteroaryl of R 11a is pyrrole, furan, thiophene, pyridine, azonine, imidazole, pyrazole, oxazole, isoxazole, thiazole, isothiazole, diazine, triazine, tetrazine, pentazine, or diazepine.

16. The compound of claim 13 , wherein the compound has Formula (IVc):

or a stereoisomer, salt, or tautomer thereof, wherein

represents 4-8 membered heterocycloalkyl or 5-8 membered heteroaryl.

17. The compound of claim 16 , wherein

has one of the following structures:

18. The compound of claim 16 , wherein

19. The compound of claim 12 , wherein R 11b is —NX 2 —.

20. The compound of claim 19 , wherein R 11b has one of the following structures:

21. The compound of claim 11 , wherein the compound has one of the following structures: