Flow channel structure for removing foreign substance, method for removing foreign substance, and method for manufacturing lipid particles
A flow channel structure for removing a foreign substance includes a first flow channel, where the first flow channel has a first region having a depth shallower than a depth of another region. A method for removing a foreign substance in a fluid includes flowing the fluid to the first flow channel of the flow channel structure for removing a foreign substance.
1 . A flow channel structure for removing a foreign substance in each of two liquids and mixes the two liquids, comprising:
partial flow channel structures that remove the foreign substance, each of which has a first flow channel; and
a two-liquid mixing flow channel,
wherein the first flow channel has a first region having a depth shallower than a depth of another region,
wherein the two-liquid mixing flow channel has a shape in which a second flow channel and a third flow channel join a fourth flow channel,
wherein the second flow channel is connected to a downstream of one of the partial flow channel structures,
wherein the third flow channel is connected to a downstream of an another of the partial flow channel structures,
wherein the second flow channel has a second region in which the second flow channel has a depth shallower than a depth of the fourth flow channel at an end of the second flow channel close to the fourth flow channel, and
wherein the depth of the first region is less than a depth of the second region.
2 . The flow channel structure according to claim 1 , wherein the first flow channel is a cavity formed inside the flow channel structure.
3 . The flow channel structure according to claim 1 , wherein the first region has a flow channel width wider than a flow channel width of the another region.
4 . The flow channel structure according to claim 3 , wherein the flow channel width of the first region is set so that when a fluid flows to the first flow channel, an average flow velocity of the fluid in the first region is equal to or less than a flow velocity when the fluid is supplied to the first flow channel.
5 . The flow channel structure according to claim 1 , wherein the first flow channel has a shape bent at a right angle immediately in front of the first region.
6 . The flow channel structure according to claim 1 , wherein the first flow channel is curved in an arc shape, and one flow channel wall of the first flow channel has a curvature larger than a curvature of an other flow channel wall facing the one flow channel wall.
7 . The flow channel structure according to claim 1 , further comprising a structure that filters the foreign substance, the structure being provided on the first region.
8 . The flow channel structure according to claim 7 , wherein the structure that filters the foreign substance has a plurality of elongated protrusions arranged at intervals in parallel with each other along a flow direction in the first flow channel.
9 . The flow channel structure according to claim 7 , wherein the structure that filters the foreign substance has a plurality of columnar protrusions extending in a depth direction of the first flow channel.
10 . The flow channel structure according to claim 1 , wherein the first flow channel has a plurality of the first region.
11 . The flow channel structure according to claim 1 , wherein a depth and a width of the another region of the first flow channel are 0.1 mm to 3 mm.
12 . The flow channel structure according to claim 1 , further comprising:
a branching and rejoining channel downstream of the fourth flow channel,
wherein the branching and rejoining channel has a branching portion which splits an upstream flow channel into two branched flow channels, and a rejoining portion which connects said two branched flow channels downstream of each other, and
wherein one of the two branched flow channels has an area shallower in depth than the fourth flow channel at a downstream end, and the other of the two branched flow channels has an area shallower in depth than the fourth flow channel at a position other than the downstream end.
13 . A method using the flow channel structure according to claim 1 to remove the foreign substance in a fluid, the method comprising flowing the fluid to the first flow channel.
14 . A method for manufacturing lipid particles encapsulating drugs, comprising:
flowing each of a first solution containing lipids as a material of the lipid particles in an organic solvent and a second solution containing drugs in an aqueous solvent to the first flow channel of the flow channel structure according to claim 1 , and removing a foreign substance in each of the first solution and the second solution;
mixing the first solution and the second solution after the removing of the foreign substance to obtain a mixed solution; and
granulating the lipids by lowering a concentration of the organic solvent in the mixed solution to form the lipid particles encapsulating the drugs.
15 . The method according to claim 14 , wherein the mixing of the first solution and the second solution is performed using the two-liquid mixing flow channel,
wherein the first solution from which the foreign substance is removed flows to one flow channel of the second flow channel and the third flow channel, and the second solution from which the foreign substance is removed flows to an other flow channel of the second flow channel and the third flow channel.
16 . The method according to claim 14 , further comprising, after the granulating, condensing a lipid particle solution containing the lipid particles.