IP Library › Patent Application 18188831
Patent Application
App. No. 18/188,831

EXTENDED RELEASE OF NEUREGULIN FOR IMPROVED CARDIAC FUNCTION

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Quick Facts
Patent No.
US None
App. No.
18/188,831
Abstract

The present invention provides extended release compositions comprising neuregulin for preventing, treating or delaying various diseases or disorders. The present invention also provides methods for preventing, treating or delaying various diseases or disorders by extended release of neuregulin.

Claims (15)

1 . A method for treating or delaying a heart disease or disorder in a mammal, the method comprising extended release of a therapeutically effective amount of a polymer-coupled neuregulin to the mammal.

2 - 85 . (canceled)

86 . The method of claim 1 , wherein the heart disease is heart failure, cardiac hypertrophy, or myocardial infarction.

87 . The method of claim 1 , wherein the neuregulin is NRG-1β.

88 . The method of claim 1 , wherein the neuregulin comprises the amino acid sequence of SEQ ID NO: 1.

89 . The method of claim 1 , wherein the neuregulin consists of the amino acid sequence of SEQ ID NO: 1.

90 . The method of claim 1 , wherein the polymer is a water soluble polymer.

91 . The method of claim 1 , wherein said polymer is poly(ethylene glycol).

92 . The method of claim 1 , wherein said polymer is a poly(ethylene glycol) derivative.

93 . The method of claim 1 , wherein the a polymer-coupled neuregulin is neuregulin covalently attached to poly(ethylene glycol).

94 . The method of claim 93 , wherein the poly(ethylene glycol) is PEG 5000.

95 . The method of claim 93 , wherein each molecule of neuregulin is attached to one molecule of poly(ethylene glycol).

96 . The method of claim 93 , wherein each molecule of neuregulin is attached to two molecules of poly(ethylene glycol).

97 . The method of claim 93 , wherein each molecule of neuregulin is attached to more than two molecules of poly(ethylene glycol).

98 . The method of claim 1 , wherein the polymer-coupled neuregulin has the same activity as neuregulin that is not polymer-coupled.