System and method for simulating a respiratory system
View Patent ↗A system and method for simulating a human respiratory system to facilitate investigating the functioning of the respiratory system, such as the generation and effects of secondhand smoke. An aerosol generator, which may include an atomizer, is configured to generate an aerosol. A series of filter media includes, in order, an inhaling extrathoracic filter media, an inhaling tracheobronchial filter media, an alveolar filter media, an exhaling tracheobronchial filter media, and an exhaling extrathoracic filter media. Each filter media includes one or more layers of a material having a fiber diameter and a weight that simulate the corresponding region of the respiratory system. A conduit may be configured to define a path for the aerosol from the aerosol generator through the series of filter media. An instrument, such as a scanning mobility particle sizer, may be used to measure a property of a secondhand aerosol exiting the exhaling extrathoracic filter media.
1. A system for simulating a respiratory system, the system comprising:
an aerosol generator generating an aerosol;
a series of filter media including—
one or more first filter media simulating an extrathoracic region of the respiratory system,
one or more second filter media simulating a tracheobronchial region of the respiratory system, and
one or more third filter media simulating an alveolar region of the respiratory system; and
a conduit defining a path for the aerosol from the aerosol generator through the series of filter media.
2. The system of claim 1 , wherein the respiratory system is a normal human respiratory system.
3. The system of claim 1 , wherein each first filter media of the one or more first filter media includes between one and three layers of a first material having a fiber diameter of between one hundred twenty and one hundred thirty micrometers and a weight of between seventy and eighty grams per square meter.
4. The system of claim 1 , wherein each first filter media of the one or more first filter media includes one or more layers of a first material having a fiber diameter of between two hundred fifteen and two hundred twenty-five micrometers and a weight of between one hundred fifty-five and one hundred sixty-five grams per square meter.
5. The system of claim 1 , wherein each second filter media of the one or more second filter media includes between three and five layers of a second material having a fiber diameter of between eighty-five and ninety-five micrometers and a weight of between sixty-five and seventy-five grams per square meter.
6. The system of claim 1 , wherein each second filter media of the one or more second filter media includes between three and five layers of a second material having a fiber diameter of between one hundred ninety-five and two hundred five micrometers and a weight of between one hundred fifty-five and one hundred sixty-five grams per square meter.
7. The system of claim 1 , wherein each third filter media of the one or more third filter media includes between one and three layers of a third material having a fiber diameter of between two hundred twenty-five and two hundred thirty-five micrometers, and a weight of between one hundred and one hundred ten grams per square meter.
8. The system of claim 1 , wherein each third filter media of the one or more third filter media includes between three and five layers of a third material having a fiber diameter of between two hundred five and two hundred fifteen micrometers, and a weight of between one hundred forty and one hundred fifty grams per square meter.
9. The system of claim 1 , wherein each third filter media of the one or more third filter media includes one or more layers of a third material having a fiber diameter of between seven-point-five and twelve-point-five micrometers and a weight of between one hundred twenty-five and one hundred thirty-five grams per square meter.
10. The system of claim 1 , wherein—
the one or more first filter media include an inhaling extrathoracic filter media and an exhaling extrathoracic filter media; and
the one or more second filter media include an inhaling tracheobronchial filter media and an exhaling tracheobronchial filter media,
wherein the series of filter media are arranged, in order, as follows—
the inhaling extrathoracic filter media,
the inhaling tracheobronchial filter media,
the one or more third filter media simulating the alveolar region,
the exhaling tracheobronchial filter media, and
the exhaling extrathoracic filter media.
11. The system of claim 10 , further including an instrument measuring a property of a secondhand aerosol exiting the exhaling extrathoracic filter media.
12. A system for simulating a human respiratory system, the system comprising:
an aerosol generator including an atomizer generating aerosol;
a series of filter media including, in order—
an inhaling extrathoracic filter media simulating an inhaling extrathoracic region of the human respiratory system,
an inhaling tracheobronchial filter media simulating an inhaling tracheobronchial region of the human respiratory system,
an alveolar filter media simulating an alveolar region of the human respiratory system,
an exhaling tracheobronchial filter media simulating an exhaling tracheobronchial region of the human respiratory system, and
an exhaling extrathoracic filter media simulating an exhaling extrathoracic region of the human respiratory system;
a conduit defining a path for the aerosol from the aerosol generator through the series of filter media; and
an instrument measuring a property of a secondhand aerosol exiting the exhaling extrathoracic filter media.
13. The system of claim 12 , wherein each of the inhaling extrathoracic filter media and the exhaling extrathoracic filter media includes two layers of a first material having a fiber diameter of between one hundred twenty and one hundred thirty micrometers and a weight of between seventy and eighty grams per square meter.
14. The system of claim 12 , wherein each of the inhaling extrathoracic filter media and the exhaling extrathoracic filter media includes one layer of a first material having a fiber diameter of between two hundred fifteen and two hundred twenty-five micrometers and a weight of between one hundred fifty-five and one hundred sixty-five grams per square meter.
15. The system of claim 12 , wherein each of the inhaling tracheobronchial filter media and exhaling tracheobronchial filter media includes four layers of a second material having a fiber diameter of between eighty-five and ninety-five micrometers and a weight of between sixty-five and seventy-five grams per square meter.
16. The system of claim 12 , wherein each of the inhaling tracheobronchial filter media and exhaling tracheobronchial filter media includes four layers of a second material having a fiber diameter of between one hundred ninety-five and two hundred five micrometers and a weight of between one hundred fifty-five and one hundred sixty-five grams per square meter.
17. The system of claim 12 , wherein the alveolar filter media includes two layers of a third material having a fiber diameter of between two hundred twenty-five and two hundred thirty-five micrometers, and a weight of between one hundred and one hundred ten grams per square meter.
18. The system of claim 12 , wherein the alveolar filter media includes four layers of a third material having a fiber diameter of between two hundred five and two hundred fifteen micrometers, and a weight of between one hundred forty and one hundred fifty grams per square meter.
19. The system of claim 12 , wherein the alveolar filter media includes one layer of a third material having a fiber diameter of between seven-point-five and twelve-point-five micrometers and a weight of between one hundred twenty-five and one hundred thirty-five grams per square meter.
20. A method of simulating a human respiratory system, the system comprising:
artificially generating an aerosol;
passing the aerosol through a series of filter media, the series of filter media including, in order—
an inhaling extrathoracic filter media artificially simulating an inhaling extrathoracic region of the human respiratory system,
an inhaling tracheobronchial filter media artificially simulating an inhaling tracheobronchial region of the human respiratory system,
the one or more alveolar filter media artificially simulating an alveolar region of the human respiratory system,
an exhaling tracheobronchial filter media artificially simulating an inhaling tracheobronchial region of the human respiratory system, and
an exhaling extrathoracic filter media artificially simulating an exhaling extrathoracic region of the human respiratory system,
wherein a secondhand aerosol exits the exhaling extrathoracic filter media; and
measuring a property of the secondhand aerosol exiting the exhaling extrathoracic filter media.