Granted Patent
B2
US 12,564,656 · App. 18/192,946 · Granted Mar 3, 2026
Sprayable tissue adhesive with biodegradation for wound treatment
Inventors:
Metecan Erdi (Bethesda, MD); Peter Kofinas (N. Bethesda, MD); Omar B. Ayyub (Washington, DC); Anthony Sandler (Bethesda, MD); Michele Saruwatari (Washington, DC)
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Abstract
Provided are compositions and methods that involve viscoelastic poly(lactide-co-caprolactone) (PLCL) mixtures for use in wound healing. The PLCL mixtures provide an improved anti-fibrotic yet tissue-adhesive polymer sealant. The PLCL mixtures can be applied to a variety of wounds arising from surgical and non-surgical tissue damage.
Claims (1)
1 . A composition consisting essentially of a mixture of 40 k and 5 k poly(L-lactide-co-caprolactone) (PLCL), wherein the 40 k and 5 k PLCL are present in a 70:30 mass ratio, respectively, wherein the composition is free of poly(lactic-co-glycolic acid) (PLGA), poly(ethylene glycol) (PEG) and nanoparticles, and when in contact with a tissue wound the composition is optionally a solid adhesive.
Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Feb 6, 2026
From: ERDI, METECAN; KOFINAS, PETER; AYYUB, OMAR B.
To: UNIVERSITY OF MARYLAND, COLLEGE PARK
Reel/Frame 073714/0120 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 21, 2026
From: ERDI, METECAN; KOFINAS, PETER
To: UNIVERSITY OF MARYLAND, COLLEGE PARK
Reel/Frame 073536/0021 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 14, 2026
From: SANDLER, ANTHONY; SARUWATARI, MICHELE
To: CHILDREN'S NATIONAL MEDICAL CENTER
Reel/Frame 073468/0949 →
CONFIRMATORY LICENSE
Recorded Jan 31, 2024
From: UNIVERSITY OF MARYLAND COLLEGE PARK
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 066383/0211 →
Continuity (2)
Provisional Application
63362192
· Mar 30, 2022
References Cited (1)
US 5583114A
· Barrows
· 1996
[cited by examiner]