Methods for the Prevention and Treatment of Hearing Loss
In one aspect, use of Afatinib as an active agent to treat a hearing loss and to prevent a hearing loss, and methods of treating and/or preventing hearing loss or disorders using the compositions are disclosed. In particular, a method for treating sensorineural hearing loss, including the steps of delivering to a patient in need thereof a composition comprising a therapeutically effective amount of Afatinib. or pharmaceutically acceptable salt thereof is provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
1 . A method of protecting ear cells from death caused by noise exposure comprising: administering to a mammal in need thereof an effective amount of a pharmaceutical composition containing a therapeutically active agent, wherein the therapeutically active agent is Afatinib.
2 . (canceled)
3 . A method to prevent hearing loss from an ototoxic event comprising: administering to a mammal in need thereof an effective amount of a pharmaceutical composition containing a therapeutically active agent, wherein the therapeutically active agent is Afatinib, wherein the ototoxic event is caused by a chemotherapeutic agent.
4 . (canceled)
5 . (canceled)
6 . (canceled)
7 . (canceled)
8 . A kit comprising: an active agent, wherein the active agent is Afatinib, or a pharmaceutically acceptable salt thereof; and one or more of:
(A) an at least one chemotherapeutic agent;
(B) an at least one antibiotic; and
(C) instructions for preventing a hearing impairment.
9 . (canceled)
10 . The kit of claim 8 , wherein the at least one chemotherapeutic agent is cisplatin.