Sample collection system including plug assembly
A biological sample collection system can include (i) a sample collection vessel having an opening for receiving a biological sample, (ii) a plug assembly that includes a post with a fluid vent therethrough, a collar disposed about the post, and a plug that initially obstructs the fluid vent, and (iii) a sealing cap coupled to the collar and comprising a reagent chamber for storing a sample preservation reagent. The sealing cap is configured to associate and form a fluid tight connection with the sample collection vessel such that associating the sealing cap with the sample collection vessel causes a physical rearrangement of the plug assembly such that the plug is detached from the post, thereby permitting sample preservation reagent to pass from the regent chamber to the sample collection vessel.
1. A biological sample collection system, comprising:
a sample collection vessel having an opening for receiving a biological sample;
a plug assembly comprising:
a post having a fluid vent, the post configured to at least partially associate with the opening of the sample collection vessel;
a collar disposed about the post; and
a plug attached to the post, the plug obstructing the fluid vent when attached to the post in a closed configuration of the plug assembly; and
a sealing cap configured to attach to the plug assembly and connect to the sample collection vessel, the sealing cap comprising a reagent chamber for storing a sample preservation reagent,
wherein the collar is secured to the sealing cap and creates a fluid tight seal with a sidewall of the post,
wherein connecting the sealing cap with the sample collection vessel causes a physical rearrangement of the plug assembly such that the plug is detached from the post and the fluid vent is unobstructed by the plug in an open configuration of the plug assembly, thereby permitting sample preservation reagent to pass from the regent chamber into the sample collection vessel.
2. The biological sample collection system of claim 1 , wherein the plug forms a fluid tight seal with the collar in the closed configuration of the plug assembly.
3. The biological sample collection system of claim 2 , wherein the plug includes a head sized and shaped to overlay a portion of the collar, forming a fluid tight connection therebetween in the closed configuration of the plug assembly.
4. The biological sample collection system of claim 2 , wherein the collar includes an aperture and the plug has a plug body sized and shaped to fit within the aperture of the collar such that a fluid tight connection is formed between the plug body and a sidewall of the collar in the closed configuration of the plug assembly.
5. The biological sample collection system of claim 1 , wherein the collar is configured to move in unison with the sealing cap when the sealing cap is connected to the sample collection vessel.
6. The biological sample collection system of claim 1 , wherein the post includes a flange sized and shaped to fit over the opening of the sample collection vessel to prevent ingress of the post into a sample collection chamber of the sample collection vessel.
7. The biological sample collection system of claim 1 , wherein the plug is dislodged into the reagent chamber in the open configuration of the plug assembly.
8. The biological sample collection system of claim 7 , wherein the dislodged plug functions as an agitator within the reagent chamber.
9. The biological sample collection system of claim 1 , wherein the sample collection vessel further comprises a connection member and the sealing cap further comprises a complementary connection member configured to associate with the connection member of the sample collection vessel to couple the sample collection vessel and the sealing cap.
10. The biological sample collection system of claim 9 , wherein the connection member comprises a ridge projecting away from the sample collection vessel or a depression within the sample collection vessel and the complementary connection member comprises a depression or ridge sized and shaped to engage the connection member.
11. The biological sample collection system of claim 9 , wherein the connection member and the complementary connection member comprise threads.
12. The biological sample collection system of claim 11 , wherein the threads of the complementary connection member comprise internal threads of the sealing cap.
13. The biological sample collection system of claim 1 , further comprising a sample preservation reagent in the reagent chamber.
14. A kit for collecting and preserving a biological sample, comprising the biological sample collection system of claim 1 .
15. The kit of claim 14 , further comprising a funnel configured to connect to the sample collection vessel and to guide receipt of a biological sample from a user into the sample collection chamber of the sample collection vessel.
16. A method of for collecting and preserving a biological sample, comprising:
receiving a biological sample at the biological sample collection system of claim 1 ; and
connecting the sealing cap to the sample collection vessel to cause the plug to detach from the post in the open configuration of the plug assembly, thereby causing or allowing sample preservation reagent to pass from the regent chamber into the sample collection vessel.
17. The method of claim 16 , wherein the biological sample collection system further includes a removable funnel connected to the sample collection vessel and wherein the biological sample is received through the funnel and guided by the funnel into the sample collection vessel.
18. The method of claim 16 , further comprising removing the funnel from the sample collection vessel before connecting the sealing cap to the sample collection vessel.
19. A biological sample collection system, comprising:
a sample collection vessel having an opening for receiving a biological sample;
a plug assembly comprising:
a post having a fluid vent, the post configured to at least partially associate with the opening of the sample collection vessel, wherein the post includes a flange sized and shaped to fit over the opening of the sample collection vessel to prevent ingress of the post into a sample collection chamber of the sample collection vessel;
a plug attached to the post, the plug obstructing the fluid vent when attached to the post in a closed configuration of the plug assembly; and
a sealing cap configured to attach to the plug assembly and connect to the sample collection vessel, the sealing cap comprising a reagent chamber for storing a sample preservation reagent,
wherein connecting the sealing cap with the sample collection vessel causes a physical rearrangement of the plug assembly such that the plug is detached from the post and the fluid vent is unobstructed by the plug in an open configuration of the plug assembly, thereby permitting sample preservation reagent to pass from the regent chamber into the sample collection vessel.