Filling nozzle
The present invention provides a filling nozzle obtained by using a resin selected from a cycloolefin polymer and a cycloolefin copolymer, or a filling nozzle including a tubular passage for supplying a pharmaceutical solution, and a filling port disposed at a lower end of the tubular passage, in which the tubular passage and the filling port have a circular peripheral cross-section, and an inner diameter of the passage of the filling port is larger than an inner diameter of the tubular passage disposed on an upstream side.
1. A filling nozzle, comprising a nozzle body having a tubular passage for supplying a pharmaceutical solution, and a filling port having a passage formed continuously to a lower end of the tubular passage, for discharging the pharmaceutical solution from a tip of the filling port, wherein the tubular passage of the nozzle body and the passage of the filling port have a circular peripheral cross-section, an inner diameter of the passage of the filling port is larger than an inner diameter of the tubular passage disposed on an upstream side, the tubular passage is connected to the passage of the filling port via an inclined portion having an inner diameter increasing in a downstream direction, the inner diameter of the tubular passage of the nozzle body is 1 to 5 mm, a length of the passage of the filling port is 1 to 10 mm, and a ratio of a length of the filling port in the length direction of the filling nozzle to an inner diameter at the end of the filling port is 0.7 to 1.8, and the filling nozzle is formed by using a material having a water contact angle of 50 to 120 degrees.
2. The filling nozzle of claim 1 , wherein the inner diameter of the passage of the filling port in a connecting portion to the tubular passage or an inclined portion is larger than an inner diameter of the connecting portion to the tubular passage or the inclined portion.
3. The filling nozzle a of claim 1 , wherein the material is a resin having a water contact angle of 80 to 94 degrees.
4. The filling nozzle of claim 1 , wherein the material is a resin selected from a cycloolefin polymer and a cycloolefin copolymer.
5. The filling nozzle of claim 1 , wherein the material is selected from a cycloolefin copolymer that is a copolymer of a cyclic olefin and an olefin, a cycloolefin ring-opening polymer, and a hydrogenated product of the cycloolefin ring-opening polymer.
6. The filling nozzle of claim 1 , wherein the material is an ethylene-norbornene copolymer.
7. The filling nozzle of claim 6 , wherein the ethylene-norbornene copolymer contains a repeating structure derived from addition polymerization of norbornene.
8. The filling nozzle of claim 1 , wherein the material is selected from a norbornene ring-opening polymer that may be substituted with C 1-6 alkyl, and a hydrogenated product of the ring-opening polymer.
9. A production method for a liquid pharmaceutical formulation, comprising a step of filling a pharmaceutical solution in a vessel by using the filling nozzle of claim 1 .
10. The production method of claim 9 , wherein an active ingredient contained in the pharmaceutical solution is an antibody.