Compositions comprising cannabinoids and methods of use
The present disclosure is related to the use of compositions and their use in reducing and treating pain.
1. A method of treating migraine pain, the method comprising administering a composition comprising a pharmaceutically effective amount of CBD and THC to a subject in need thereof, thereby reducing migraine pain in the subject, wherein the weight ratio of CBD to THC is about 100:1.
2. The method of claim 1 , wherein the administering is accomplished via injection.
3. The method of claim 1 , wherein the treatment is effective within 2 hours post-administration.
4. The method of claim 3 , wherein the treatment is effective within 30 minutes post-administration.
5. The method of claim 4 , wherein the treatment is effective within 15 minutes post-administration.
6. The method of claim 1 , wherein the migraine pain is acute migraine pain.
7. The method of claim 1 , wherein the migraine pain is measured by a pain scale.
8. The method of claim 1 , wherein the THC and the CBD are at least 90 wt % pure.
9. The method of claim 1 , wherein the composition further comprises at least one minor cannabinoid.
10. The method of claim 9 , wherein the at least one minor cannabinoid is at least 90 wt % pure.
11. The method of claim 9 , wherein the at least one minor cannabinoid is selected from the group consisting of CBG, CBGA, CBN, CBNA, THCV, THCA, CBC, CBCA, CBDV, and D8-THC.
12. The method of claim 1 , wherein at least one biomarker of central and peripheral sensitization is modulated as a result of the administration.
13. The method of claim 12 , wherein the at least one biomarker is selected from the group consisting of NMDA, glutamate, CGRP, FAAH, Substance P, 5-HT, NO, GABA, NGF, serotonin, dopamine, AEA, and 2-AG.
14. The method of claim 1 , wherein the composition comprises an amount of CBD to reduce unwanted side effects or risk factors associated with THC.
15. The method of claim 14 , wherein the unwanted side effects or risk factors include psychoactivity, psychosis, anxiety, paranoia, dizziness, confusion, increased heart rate, memory impairment, or combinations thereof.
16. A method of treating migraine pain, the method comprising administering a composition comprising a pharmaceutically effective amount of at least one minor cannabinoid in combination with THC and CBD to a subject in need thereof, thereby reducing migraine pain in the subject, wherein the weight ratio of CBD to THC is about 100:1.
17. The method of claim 16 , wherein the composition comprises an amount of CBD to reduce unwanted side effects or risk factors associated with THC.
18. The method of claim 17 , wherein the unwanted side effects or risk factors include psychoactivity, psychosis, anxiety, paranoia, dizziness, confusion, increased heart rate, memory impairment, or combinations thereof.
19. The method of claim 16 , wherein the treatment is effective within 2 hours post-administration.