Antioxidant contact lens

1. A method of manufacturing an antioxidant contact lens comprising polymerizing a monomer mixture comprising at least one silicone monomer and at least one hydrophilic monomer to provide a lens-shaped polymerization product; extracting the polymerization product in an organic solvent comprising 0.2 mg/mL to 10 mg/mL vitamin E; hydrating the polymerization product to form a silicone hydrogel contact lens; and sterilely sealing the contact lens in a package, wherein the antioxidant contact lens (a) provides at least a 80% reduction in lipid peroxidation relative to a control contact lens lacking the vitamin E when measured in a TBARS assay, (b) has a heat stability that is no greater than that of the control contact lens, and (c) is free of a bioactive agent having a release profile attenuated by the vitamin E.

2. A sealed contact lens package comprising:

a) a plastic base member having a cavity;

b) a contact lens packaging solution in said cavity;

c) a sterile, unworn contact lens immersed in said contact lens packaging solution in said cavity; and

d) a cover that forms a liquid-tight seal with the plastic base member,

wherein the unworn contact lens is a silicone hydrogel contact lens having present therein at least 10 μg of vitamin E per 25 mg of the sterile, unworn contact lens when fully hydrated and 0 μg of a bioactive agent, and said vitamin E is non-releasable from said unworn contact lens and said contact lens packaging solution has less than 1 ppm of vitamin E present.

3. The sealed contact lens package of claim 2 , wherein said vitamin E is trapped, embedded, absorbed, or non-covalently attached in said unworn contact lens.

4. The sealed contact lens package of claim 2 , wherein said vitamin E provides at least a 50% reduction in lipid peroxidation relative to a control contact lens lacking the vitamin E when measured in a TBARS assay.

5. The sealed contact lens package of claim 2 , wherein said unworn contact lens is in the absence of any agent that provides antioxidant properties except for said vitamin E.

6. The sealed contact lens package of claim 2 , wherein the unworn contact lens has (a) an ophthalmically-acceptable surface wettability in the absence of a post curing surface treatment or (b) an advancing contact angle that is no more than 10° greater than the control lens, or both (a) and (b).

7. The sealed contact lens package of claim 2 , wherein the unworn contact lens (a) has a heat stability that is no greater than a control contact lens lacking the vitamin E.

8. The sealed contact lens package of claim 2 , wherein the unworn contact lens has about the same coefficient of friction after an overnight wash compared to a control contact lens lacking the vitamin E.

9. The sealed contact lens package of claim 2 , wherein said sterile, unworn contact lens has at least one silicone hydrogel property that is same or substantially the same as a control lens lacking said vitamin E.

10. The sealed contact lens package of claim 9 , wherein said silicone hydrogel property is surface wettability, advancing contact angle, % EWC, lens diameter, or amount of water or aqueous fluid needed to obtain a fully hydrated contact lens.

11. The sealed contact lens package of claim 2 , wherein the vitamin E is effective to reduce generation of reactive oxygen species (ROS) from human corneal epithelial cells (HCECs) contacted in vitro with H 2 O 2 relative to the control contact lens when measured in an HCEC viability assay.

12. A method to control lipid peroxidation from tear film in an eye of a person wearing a contact lens, said method comprising inserting a sterile, unworn contact lens in the eye of said person to correct vision in said eye of said person, and wherein the sterile, unworn contact lens is a silicone hydrogel contact lens having therein an amount of vitamin E that is at least 20 μg of vitamin E per 25 mg of the sterile, unworn contact lens when fully hydrated and 0 μg of a bioactive agent, and said vitamin E is non-releasable from said sterile, unworn contact lens when worn in the eye.

13. The method of claim 12 , wherein said method provides at least a 50% reduction in said lipid peroxidation relative to a control contact lens lacking the vitamin E when measured in a TBARS assay.

14. The method of claim 12 , wherein said vitamin E is trapped, embedded, absorbed, or non-covalently attached in said sterile, unworn contact lens.

15. The method of claim 12 , wherein said method is in the absence of utilizing any agent that provides antioxidant properties except for said vitamin E.