Nicotine liquid formulations for aerosol devices and methods thereof
A nicotine liquid formulation comprising nicotine, an acid, and a biologically acceptable liquid carrier, wherein heating an amount of said nicotine liquid formulation using low temperature electronic vaporization device, i.e., an electronic cigarette, generates an inhalable aerosol, and wherein at least about 50% of said acid in said amount is in said aerosol, and wherein at least about 90% of said nicotine in said amount is in said aerosol.
1. A method of generating an inhalable aerosol comprising nicotine for delivery to a user using an electronic vaporization device comprising a nicotine salt liquid formulation and a heater, the method comprising:
(i) providing an amount of the nicotine salt liquid formulation to the heater, wherein
(a) the nicotine salt liquid formulation comprises at least one nicotine salt in a biologically acceptable liquid carrier;
(b) the at least one nicotine salt comprises a salt of nicotine and salicylic acid;
(c) the nicotine salt liquid formulation has a nicotine salt concentration of 0.5% (w/w) to 20% (w/w); and
(d) the nicotine salt liquid formulation has a molar ratio of salicylic acid to nicotine from 0.7:1 to 1.6:1, and
(ii) forming an aerosol by heating the amount of the nicotine salt liquid formulation.
2. The method of claim 1 , wherein the nicotine salt concentration is from 1% (w/w) to 15% (w/w).
3. The method of claim 2 , wherein the nicotine salt concentration is from 1% (w/w) to 6% (w/w).
4. The method of claim 1 , wherein the biologically acceptable liquid carrier comprises from 10% to 70% of propylene glycol and from 90% to 30% of vegetable glycerin.
5. The method of claim 4 , wherein the biologically acceptable liquid carrier comprises from 20% to 50% of propylene glycol and from 80% to 50% of vegetable glycerin.
6. The method of claim 1 , wherein the nicotine salt liquid formulation has a molar ratio of salicylic acid to nicotine of about 1:1.
7. The method of claim 1 , wherein the nicotine salt liquid formulation further comprises an additional acid selected from the group consisting of benzoic acid, pyruvic acid, levulinic acid, malic acid, succinic acid, and citric acid.
8. The method of claim 7 , wherein the additional acid forms an additional nicotine salt.
9. The method of claim 1 , comprising heating the amount of the nicotine salt liquid formulation from 100° C. to 300° C.
10. The method of claim 1 , wherein the amount is at least 60 μL or at least 60 mg.
11. The method of claim 10 , wherein the amount is provided over a plurality of puffs, and the amount provided per puff is at least 1 μL or at least 1 mg.
12. A nicotine salt liquid formulation comprising at least one nicotine salt in a biologically acceptable liquid carrier, wherein:
(a) the at least one nicotine salt comprises a salt of nicotine and salicylic acid;
(b) the nicotine salt liquid formulation has a nicotine salt concentration of 1% (w/w) to 20% (w/w); and
(c) the nicotine salt liquid formulation has a molar ratio of salicylic acid to nicotine from 0.7:1 to 1.6:1.
13. The nicotine salt liquid formulation of claim 12 , wherein the nicotine salt concentration is from 1% (w/w) to 15% (w/w).
14. The nicotine salt liquid formulation of claim 13 , wherein the nicotine salt concentration is from 1% (w/w) to 6% (w/w).
15. The nicotine salt liquid formulation of claim 12 , wherein the biologically acceptable liquid carrier comprises from 10% to 70% of propylene glycol and from 90% to 30% of vegetable glycerin.
16. The nicotine salt liquid formulation of claim 15 , wherein the biologically acceptable liquid carrier comprises from 20% to 50% of propylene glycol and from 80% to 50% of vegetable glycerin.
17. The nicotine salt liquid formulation of claim 12 , wherein the nicotine salt liquid formulation has a molar ratio of salicylic acid to nicotine of about 1:1.
18. A method of generating an inhalable aerosol comprising nicotine for delivery to a user using an electronic vaporization device comprising a nicotine liquid formulation and a heater, the method comprising:
(i) providing an amount of the nicotine liquid formulation to the heater, wherein
(a) the nicotine liquid formulation comprises from 0.5% (w/w) to 20% (w/w) of nicotine, salicylic acid, and a biologically acceptable liquid carrier; and
(b) the molar ratio of salicylic acid to nicotine is from 0.7:1 to 1.6:1, and
(ii) forming an aerosol by heating the amount of the nicotine liquid formulation.
19. The method of claim 18 , wherein the nicotine liquid formulation comprises from 1% (w/w) to 15% (w/w) of nicotine.
20. The method of claim 19 , wherein the nicotine liquid formulation comprises from 1% (w/w) to 6% (w/w) of nicotine.
21. The method of claim 18 , wherein the biologically acceptable liquid carrier comprises from 10% to 70% of propylene glycol and from 90% to 30% of vegetable glycerin.
22. The method of claim 21 , wherein the biologically acceptable liquid carrier comprises from 20% to 50% of propylene glycol and from 80% to 50% of vegetable glycerin.
23. The method of claim 18 , wherein the nicotine liquid formulation has a molar ratio of salicylic acid to nicotine of about 1:1.
24. The method of claim 18 , comprising forming an aerosol by heating the amount of the nicotine liquid formulation from 100° C. to 300° C.
25. The method of claim 18 , wherein the amount is at least 60 μL or at least 60 mg.