IP Library › Granted Patent US 12,702,698
Granted Patent B2
US 12,702,698 · App. 18/226,405 · Granted Aug 11, 2026

GLP-1 compositions and uses thereof

Inventors: Eva Horn Moeller (Alleroed, DK); Michael Duelund Soerensen (Soeborg, DK); Joakim Lundqvist (Malmoe, SE)
Assignee: Novo Nordisk A/S
A61K38/26A61K9/0019A61K9/08A61K47/02A61K47/10
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Quick Facts
Patent No.
US 12,702,698
App. No.
18/226,405
Filed
Jul 26, 2023
Granted
Aug 11, 2026
Kind
B2
Art Unit
1658
USPC
514/11.7
Abstract

The present invention relates to pharmaceutical compositions of the GLP-1 peptide semaglutide comprising no more than 0.01% (w/w) phenol, their preparation, kits comprising such compositions as well as uses thereof.

Claims (26)

1 . A liquid pharmaceutical composition comprising:

semaglutide;

wherein said composition

(a) does not contain phenol; and

(b) is for subcutaneous administration; and

(c) (i) is an aqueous solution comprising at least 60% (w/w) water or (ii) further comprises one or more pharmaceutically acceptable excipients selected from the group consisting of a buffer or an isotonic agent; and

wherein the semaglutide is in the range of 0.50 mg/mL −3.2 mg/mL; and

wherein the pH of the composition is about 7.4.

2 . A method of treating diabetes comprising administering to a subject in need of such method a therapeutically effective amount of the liquid pharmaceutical composition according to claim 1 .

3 . A method of treating obesity comprising administering to a subject in need of such method a therapeutically effective amount of the liquid pharmaceutical composition according to claim 1 .

4 . The liquid pharmaceutical composition of claim 1 , wherein the semaglutide is 0.5 mg/mL.

5 . The liquid pharmaceutical composition of claim 1 , wherein the semaglutide is 1.0 mg/mL.

6 . The liquid pharmaceutical composition of claim 1 , wherein the semaglutide is 1.7 mg/0.75 mL.

7 . The liquid pharmaceutical composition of claim 1 , where in the semaglutide is 2.0 mg/mL.

8 . The liquid pharmaceutical composition of claim 1 , wherein the semaglutide is 3.2 mg/mL.

9 . The liquid pharmaceutical composition of claim 1 , wherein the buffer comprises disodiumhydrogenphosphate dihydrate or trisodiumcitrate dihydrate.

10 . The liquid pharmaceutical composition of claim 9 , wherein the disodiumhydrogenphosphate dihydrate is 1.42 mg/mL.

11 . The liquid pharmaceutical composition of claim 9 , wherein the trisodiumcitrate dihydrate is 2.35 mg/mL.

12 . The liquid pharmaceutical composition of claim 1 , wherein the isotonic agent is propylene glycol or sodium chloride.

13 . The liquid pharmaceutical composition of claim 12 , wherein the propylene glycol is 14 mg/mL.

14 . The liquid pharmaceutical composition of claim 12 , wherein the sodium chloride is 8.25 mg/mL.

15 . The liquid pharmaceutical composition of claim 12 , wherein the sodium chloride is 6.3 mg/mL.

16 . The liquid pharmaceutical composition of claim 1 , further comprising one or more pharmaceutically acceptable excipients to adjust the pH.

17 . The liquid pharmaceutical composition of claim 16 , wherein the one or more pharmaceutically acceptable excipients comprise hydrochloric acid or sodium hydroxide.

18 . The liquid pharmaceutical composition of claim 16 , wherein the one or more pharmaceutically acceptable excipients comprise hydrochloric acid and sodium hydroxide.

19 . The liquid pharmaceutical composition of claim 1 , wherein said liquid pharmaceutical composition comprises no preservative.

Priority Claims (1)
EP 17187676 · Aug 24, 2017 · regional
Continuity (4)
Continuation 17115773 · Dec 8, 2020
Continuation 16774666 · Jan 28, 2020
Continuation PCTEP2018072835 · Aug 24, 2018
Related Publication 20240016896A1 · Jan 18, 2024
References Cited (400)
US 2444570A · Lawrence et al. · 1948 [cited by applicant]
US 2828742A · Ashkenaz · 1958 [cited by applicant]
US 3318289A · Marynissen · 1967 [cited by applicant]
US 3758683A · Jackson · 1973 [cited by applicant]
US 4282316A · Modrovich · 1981 [cited by applicant]
US 4425346A · Horlington · 1984 [cited by applicant]
US 4468346A · Paul et al. · 1984 [cited by applicant]
US 4470317A · Sabloewski et al. · 1984 [cited by applicant]
US 4483849A · Carter et al. · 1984 [cited by applicant]
US 4498904A · Turner et al. · 1985 [cited by applicant]
US 4568335A · Updike et al. · 1986 [cited by applicant]
US 4585439A · Michel · 1986 [cited by applicant]
US 4592745A · Rex et al. · 1986 [cited by applicant]
US 4629455A · Kanno · 1986 [cited by applicant]
US 4833379A · Kaibel et al. · 1989 [cited by applicant]
US 4865591A · Sams · 1989 [cited by applicant]
US 4883472A · Michel · 1989 [cited by applicant]
US 4917685A · Viswanathan et al. · 1990 [cited by applicant]
US 4919596A · Slate et al. · 1990 [cited by applicant]
US 4936833A · Sams · 1990 [cited by applicant]
US 4973318A · Holm et al. · 1990 [cited by applicant]
US 4994033A · Shockey et al. · 1991 [cited by applicant]
US 5017190A · Simon et al. · 1991 [cited by applicant]
US 5092842A · Bechtold et al. · 1992 [cited by applicant]
US 5112317A · Michel · 1992 [cited by applicant]
US 5114406A · Gabriel et al. · 1992 [cited by applicant]
US 5118666A · Habener · 1992 [cited by applicant]
US 5120712A · Habener · 1992 [cited by applicant]
US 5169759A · Faust et al. · 1992 [cited by applicant]
US 5169771A · Christner et al. · 1992 [cited by applicant]
US 5206216A · Yoshida · 1993 [cited by applicant]
US 5206219A · Desai · 1993 [cited by applicant]
US 5207752A · Sorenson et al. · 1993 [cited by applicant]
US 5216011A · Paborji et al. · 1993 [cited by applicant]
US 5216437A · Yamamoto et al. · 1993 [cited by applicant]
US 5226895A · Harris · 1993 [cited by applicant]
US 5232459A · Hjertman · 1993 [cited by applicant]
US 5232706A · Palomo Coll · 1993 [cited by applicant]
US 5246417A · Haak et al. · 1993 [cited by applicant]
US 5257987A · Athayde et al. · 1993 [cited by applicant]
US 5271527A · Haber et al. · 1993 [cited by applicant]
US 5272135A · Takruri · 1993 [cited by applicant]
US 5279585A · Balkwill · 1994 [cited by applicant]
US 5279586A · Balkwill · 1994 [cited by applicant]
US 5281198A · Haber et al. · 1994 [cited by applicant]
US 5284480A · Porter et al. · 1994 [cited by applicant]
US 5304152A · Sams · 1994 [cited by applicant]
US 5308340A · Harris · 1994 [cited by applicant]
US 5314412A · Rex · 1994 [cited by applicant]
US 5318540A · Athayde et al. · 1994 [cited by applicant]
US 5320609A · Haber et al. · 1994 [cited by applicant]
US 5331954A · Rex et al. · 1994 [cited by applicant]
US 5370629A · Michel et al. · 1994 [cited by applicant]
US 5378233A · Haber et al. · 1995 [cited by applicant]
US 5380297A · Wadman et al. · 1995 [cited by applicant]
US 5383166A · Gallay · 1995 [cited by applicant]
US 5383865A · Michel · 1995 [cited by applicant]
US 5440976A · Giuliano et al. · 1995 [cited by applicant]
US 5445606A · Haak et al. · 1995 [cited by applicant]
US 5447150A · Bacon · 1995 [cited by applicant]
US 5455331A · Pearce · 1995 [cited by applicant]
US 5461031A · De Felippis · 1995 [cited by applicant]
US 5478316A · Bitdinger et al. · 1995 [cited by applicant]
US 5478324A · Meyer · 1995 [cited by applicant]
US 5480387A · Gabriel et al. · 1996 [cited by applicant]
US 5492534A · Athayde et al. · 1996 [cited by applicant]
US 5505704A · Pawelka et al. · 1996 [cited by applicant]
US 5512549A · Chen et al. · 1996 [cited by applicant]
US 5514097A · Knauer · 1996 [cited by applicant]
US 5545147A · Harris · 1996 [cited by applicant]
US 5545618A · Buckley et al. · 1996 [cited by applicant]
US 5546932A · Galli · 1996 [cited by applicant]
US 5549574A · Townsend · 1996 [cited by applicant]
US 5549575A · Giambattista et al. · 1996 [cited by applicant]
US 5571719A · Christensen et al. · 1996 [cited by applicant]
US 5574008A · Johnson et al. · 1996 [cited by applicant]
US 5584815A · Pawelka et al. · 1996 [cited by applicant]
US 5591136A · Gabriel · 1997 [cited by applicant]
US 5599314A · Neill · 1997 [cited by applicant]
US 5611783A · Mikkelsen · 1997 [cited by applicant]
US 5614492A · Habener · 1997 [cited by applicant]
US 5626566A · Petersen et al. · 1997 [cited by applicant]
US 5645052A · Kersey · 1997 [cited by applicant]
US 5652216A · Kornfelt et al. · 1997 [cited by applicant]
US 5674204A · Chanoch · 1997 [cited by applicant]
US 5679111A · Hjertman et al. · 1997 [cited by applicant]
US 5681285A · Ford et al. · 1997 [cited by applicant]
US 5685864A · Shanley et al. · 1997 [cited by applicant]
US 5686411A · Gaeta et al. · 1997 [cited by applicant]
US 5688251A · Chanoch · 1997 [cited by applicant]
US 5693027A · Hansen et al. · 1997 [cited by applicant]
US 5693520A · Branner et al. · 1997 [cited by applicant]
US 5693608A · Bechgaard et al. · 1997 [cited by applicant]
US 5705483A · Galloway et al. · 1998 [cited by applicant]
US 5709662A · Olive et al. · 1998 [cited by applicant]
US 5716990A · Bagshawe et al. · 1998 [cited by applicant]
US 5725508A · Chanoch et al. · 1998 [cited by applicant]
US 5741688A · Slashed et al. · 1998 [cited by applicant]
US 5743889A · Sams · 1998 [cited by applicant]
US 5750140A · Weibel et al. · 1998 [cited by applicant]
US 5755692A · Manicom · 1998 [cited by applicant]
US 5823998A · Yamagata · 1998 [cited by applicant]
US 5827232A · Chanoch et al. · 1998 [cited by applicant]
US 5843036A · Olive et al. · 1998 [cited by applicant]
US 5849700A · Sørensen et al. · 1998 [cited by applicant]
US 5882718A · Pommer et al. · 1999 [cited by applicant]
US 5898028A · Jensen et al. · 1999 [cited by applicant]
US 5908830A · Smith et al. · 1999 [cited by applicant]
US 5921966A · Bendek et al. · 1999 [cited by applicant]
US 5928201A · Poulsen et al. · 1999 [cited by applicant]
US 5932547A · Stevenson et al. · 1999 [cited by applicant]
US 5938642A · Burroughs et al. · 1999 [cited by applicant]
US 5947934A · Hansen et al. · 1999 [cited by applicant]
US 5951530A · Steengaard et al. · 1999 [cited by applicant]
US 5954689A · Poulsen · 1999 [cited by applicant]
US 5961496A · Nielsen et al. · 1999 [cited by applicant]
US 5962407A · Kelly · 1999 [cited by applicant]
US 5972873A · Nielsen et al. · 1999 [cited by applicant]
US 5980491A · Hansen · 1999 [cited by applicant]
US 5981489A · Stevenson et al. · 1999 [cited by applicant]
US 5984900A · Mikkelsen · 1999 [cited by applicant]
US 5985629A · Aaslyng et al. · 1999 [cited by applicant]
US 5989169A · Svendsen et al. · 1999 [cited by applicant]
US 6003736A · Ljunggren · 1999 [cited by applicant]
US 6004297A · Steenfeldt-Jensen et al. · 1999 [cited by applicant]
US 6010485A · Buch-Rasmussen et al. · 2000 [cited by applicant]
US 6033376A · Rockley · 2000 [cited by applicant]
US 6033377A · Rasmussen et al. · 2000 [cited by applicant]
US 6048336A · Gabriel · 2000 [cited by applicant]
US 6059616A · Bluemmel et al. · 2000 [cited by applicant]
US 6066619A · Stevenson et al. · 2000 [cited by applicant]
US 6074372A · Hansen · 2000 [cited by applicant]
US 6083197A · Umbaugh · 2000 [cited by applicant]
US 6086567A · Kirchhofer et al. · 2000 [cited by applicant]
US 6096010A · Walters et al. · 2000 [cited by applicant]
US 6110149A · Klitgaard et al. · 2000 [cited by applicant]
US 6129080A · Pitcher et al. · 2000 [cited by applicant]
US 6133229A · Gibson et al. · 2000 [cited by applicant]
US 6136784A · L'Italien et al. · 2000 [cited by applicant]
US 6146361A · DiBiasi et al. · 2000 [cited by applicant]
US 6184201B1 · Drucker et al. · 2001 [cited by applicant]
US 6193698B1 · Kirchhofer et al. · 2001 [cited by applicant]
US 6207684B1 · Aberg · 2001 [cited by applicant]
US 6221046B1 · Burroughs et al. · 2001 [cited by applicant]
US 6221053B1 · Walters et al. · 2001 [cited by applicant]
US 6231540B1 · Smedegaard · 2001 [cited by applicant]
US 6235004B1 · Steenfeldt-Jensen et al. · 2001 [cited by applicant]
US 6245572B1 · Wall · 2001 [cited by applicant]
US 6248090B1 · Jensen et al. · 2001 [cited by applicant]
US 6248095B1 · Giambattista et al. · 2001 [cited by applicant]
US 6258062B1 · Thielen et al. · 2001 [cited by applicant]
US 6268343B1 · Knudsen et al. · 2001 [cited by applicant]
US 6269340B1 · Ford et al. · 2001 [cited by applicant]
US 6274553B1 · Furuya et al. · 2001 [cited by applicant]
US 6277097B1 · Mikkelsen et al. · 2001 [cited by applicant]
US 6277098B1 · Klitmose et al. · 2001 [cited by applicant]
US 6281225B1 · Hearst et al. · 2001 [cited by applicant]
US 6283941B1 · Schoenfeld et al. · 2001 [cited by applicant]
US 6284727B1 · Kim et al. · 2001 [cited by applicant]
US 6287283B1 · Ljunggreen et al. · 2001 [cited by applicant]
US 6302869B1 · Klitgaard · 2001 [cited by applicant]
US 6303661B1 · Demuth et al. · 2001 [cited by applicant]
US 6312413B1 · Jensen et al. · 2001 [cited by applicant]
US 6340357B1 · Poulsen et al. · 2002 [cited by applicant]
US 6375975B1 · Modi · 2002 [cited by applicant]
US 6379339B1 · Klitgaard et al. · 2002 [cited by applicant]
US 6380357B2 · Hermeling et al. · 2002 [cited by applicant]
US 6384016B1 · Kaarsholm · 2002 [cited by applicant]
US 6440460B1 · Gumny et al. · 2002 [cited by applicant]
US 6440930B1 · Rinella, Jr. · 2002 [cited by applicant]
US 6444788B1 · Staby · 2002 [cited by applicant]
US 6458924B2 · Knudsen et al. · 2002 [cited by applicant]
US 6489292B1 · Havelund et al. · 2002 [cited by applicant]
US 6514230B1 · Munk et al. · 2003 [cited by applicant]
US 6547763B2 · Steenfeldt-Jensen et al. · 2003 [cited by applicant]
US 6547764B2 · Larsen et al. · 2003 [cited by applicant]
US 6551992B1 · DeFelippis et al. · 2003 [cited by applicant]
US 6562006B1 · Hjertman et al. · 2003 [cited by applicant]
US 6562011B1 · Buch-Rasmussen et al. · 2003 [cited by applicant]
US 6569126B1 · Poulsen et al. · 2003 [cited by applicant]
US 6569832B1 · Knudsen et al. · 2003 [cited by applicant]
US 6573237B2 · Rinella, Jr. · 2003 [cited by applicant]
US 6582404B1 · Klitgaard et al. · 2003 [cited by applicant]
US 6586399B1 · Drucker · 2003 [cited by applicant]
US 6605067B1 · Larsen · 2003 [cited by applicant]
US 6613019B2 · Munk · 2003 [cited by applicant]
US 6660716B1 · Yakubu-Madus et al. · 2003 [cited by applicant]
US 6663602B2 · Moller · 2003 [cited by applicant]
US 6692472B2 · Hansen et al. · 2004 [cited by applicant]
US 6708846B1 · Fuchs et al. · 2004 [cited by applicant]
US 6716198B2 · Larsen · 2004 [cited by applicant]
US 6726661B2 · Munk et al. · 2004 [cited by applicant]
US 6770288B2 · Duirs · 2004 [cited by applicant]
US 6796970B1 · Klitmose et al. · 2004 [cited by applicant]
US 6844321B2 · Arentsen · 2005 [cited by applicant]
US 6893415B2 · Madsen et al. · 2005 [cited by applicant]
US 6899698B2 · Sams · 2005 [cited by applicant]
US 6899699B2 · Enggaard · 2005 [cited by applicant]
US 6945961B2 · Miller et al. · 2005 [cited by applicant]
US 7008399B2 · Larsen et al. · 2006 [cited by applicant]
US 7022674B2 · DeFelippis et al. · 2006 [cited by applicant]
US 7049284B2 · Drucker · 2006 [cited by applicant]
US 7056886B2 · Isaacs · 2006 [cited by applicant]
US 7090662B2 · Wimpenny et al. · 2006 [cited by applicant]
US 7094221B2 · Veasey et al. · 2006 [cited by applicant]
US 7104972B2 · Moller et al. · 2006 [cited by applicant]
US 7112187B2 · Karlsson · 2006 [cited by applicant]
US 7112567B2 · Bridon et al. · 2006 [cited by applicant]
US 7133329B2 · Skyggebjerg et al. · 2006 [cited by applicant]
US 7175055B2 · Hansen et al. · 2007 [cited by applicant]
US 7202213B2 · Mogensen et al. · 2007 [cited by applicant]
US 7226990B2 · Knudsen et al. · 2007 [cited by applicant]
US 7235627B2 · Knudson et al. · 2007 [cited by applicant]
US 7238663B2 · DeFelippis et al. · 2007 [cited by applicant]
US 7241278B2 · Moller · 2007 [cited by applicant]
US 7273921B2 · Dunweber et al. · 2007 [cited by applicant]
US 7595293B2 · Engelund et al. · 2009 [cited by applicant]
US 7632806B2 · Juul-Mortensen et al. · 2009 [cited by applicant]
US 7833531B2 · O'Neil et al. · 2010 [cited by applicant]
US 8071103B2 · O'Neil et al. · 2011 [cited by applicant]
US 8114833B2 · Pedersen et al. · 2012 [cited by applicant]
US 8129343B2 · Lau et al. · 2012 [cited by applicant]
US 8158583B2 · Knudsen et al. · 2012 [cited by applicant]
US RE43834E · Steenfeldt-Jensen et al. · 2012 [cited by applicant]
US 8541470B2 · Davis · 2013 [cited by applicant]
US 8759291B2 · Young et al. · 2014 [cited by applicant]
US 8846618B2 · Flink et al. · 2014 [cited by applicant]
US 9133276B2 · Cleemann et al. · 2015 [cited by applicant]
US 9217022B2 · Alfaro-Lopez et al. · 2015 [cited by applicant]
US 9265723B2 · Sprogoe et al. · 2016 [cited by applicant]
US 9457066B2 · Rau et al. · 2016 [cited by applicant]
US 10888605B2 · Moeller et al. · 2021 [cited by applicant]
US 11572398B2 · Sauerberg et al. · 2023 [cited by applicant]
US 11752198B2 · Moeller · 2023 [cited by examiner]
US 12214017B2 · Moeller et al. · 2025 [cited by applicant]
US 20010014666A1 · Hermeling et al. · 2001 [cited by applicant]
US 20010027180A1 · Isaacs · 2001 [cited by applicant]
US 20020007154A1 · Hansen et al. · 2002 [cited by applicant]
US 20020052578A1 · Moller · 2002 [cited by applicant]
US 20020061838A1 · Holmquist et al. · 2002 [cited by applicant]
US 20020077852A1 · Ford et al. · 2002 [cited by applicant]
US 20020120235A1 · Enggaard · 2002 [cited by applicant]
US 20020151467A1 · Leung · 2002 [cited by applicant]
US 20030039679A1 · Duirs · 2003 [cited by applicant]
US 20030045838A1 · Woodard et al. · 2003 [cited by applicant]
US 20030060412A1 · Prouty et al. · 2003 [cited by applicant]
US 20030069182A1 · Rinella · 2003 [cited by applicant]
US 20030092606A1 · L'Italien et al. · 2003 [cited by applicant]
US 20030092612A1 · Lyons · 2003 [cited by applicant]
US 20030119734A1 · Flink et al. · 2003 [cited by applicant]
US 20030158101A1 · Drucker · 2003 [cited by applicant]
US 20030172924A1 · Staniforth et al. · 2003 [cited by applicant]
US 20030207802A1 · DeFelippis et al. · 2003 [cited by applicant]
US 20030211047A1 · Dugger · 2003 [cited by applicant]
US 20030220243A1 · Glaesner et al. · 2003 [cited by applicant]
US 20030220255A1 · Knudsen et al. · 2003 [cited by applicant]
US 20040059299A1 · Moller · 2004 [cited by applicant]
US 20040156835A1 · Imoto et al. · 2004 [cited by applicant]
US 20040186431A1 · Graf et al. · 2004 [cited by applicant]
US 20040210199A1 · Atterbury et al. · 2004 [cited by applicant]
US 20040236282A1 · Braithwaite · 2004 [cited by applicant]
US 20040248782A1 · Bridon et al. · 2004 [cited by applicant]
US 20040249348A1 · Wimpenny et al. · 2004 [cited by applicant]
US 20040260247A1 · Veasey et al. · 2004 [cited by applicant]
US 20040267207A1 · Veasey et al. · 2004 [cited by applicant]
US 20050004529A1 · Veasey et al. · 2005 [cited by applicant]
US 20050009742A1 · Bertilsson et al. · 2005 [cited by applicant]
US 20050019400A1 · Deveney et al. · 2005 [cited by applicant]
US 20050033244A1 · Veasey et al. · 2005 [cited by applicant]
US 20050055011A1 · Enggaard · 2005 [cited by applicant]
US 20050143303A1 · Quay et al. · 2005 [cited by applicant]
US 20050148497A1 · Khan · 2005 [cited by applicant]
US 20050205083A1 · Staniforth et al. · 2005 [cited by applicant]
US 20050268915A1 · Wassenaar et al. · 2005 [cited by applicant]
US 20060084605A1 · Engelund et al. · 2006 [cited by applicant]
US 20060178304A1 · Juul-Mortensen et al. · 2006 [cited by applicant]
US 20060286129A1 · Sarubbi · 2006 [cited by applicant]
US 20060287221A1 · Knudsen et al. · 2006 [cited by applicant]
US 20070042956A1 · Johansen et al. · 2007 [cited by applicant]
US 20070093761A1 · Veasey et al. · 2007 [cited by applicant]
US 20080125361A1 · Ludvigsen et al. · 2008 [cited by applicant]
US 20090011976A1 · Ludvigsen et al. · 2009 [cited by applicant]
US 20090111752A1 · Flink et al. · 2009 [cited by applicant]
US 20090156478A1 · Lau · 2009 [cited by examiner]
US 20100311643A1 · Bevec et al. · 2010 [cited by applicant]
US 20120208755A1 · Leung · 2012 [cited by applicant]
US 20120225810A1 · Pedersen et al. · 2012 [cited by applicant]
US 20130190230A1 · Casadesus Smith et al. · 2013 [cited by applicant]
US 20150011462A1 · Reedtz-Runge et al. · 2015 [cited by applicant]
US 20150157619A1 · Kiyoshima et al. · 2015 [cited by applicant]
US 20150238629A1 · Kim et al. · 2015 [cited by applicant]
US 20160067184A1 · Nielsen · 2016 [cited by examiner]
US 20160235855A1 · Xiong et al. · 2016 [cited by applicant]
US 20160243199A1 · Bueche et al. · 2016 [cited by applicant]
US 20180021409A1 · Chang et al. · 2018 [cited by applicant]
US 20190133951A1 · Liu et al. · 2019 [cited by applicant]
US 20190231876A1 · Pedersen et al. · 2019 [cited by applicant]
US 20190388502A1 · Corvari et al. · 2019 [cited by applicant]
US 20200316204A1 · Pedersen et al. · 2020 [cited by applicant]
US 20210252111A1 · Engelund et al. · 2021 [cited by applicant]
AU 611385B2 · 1991 [cited by applicant]
CA 2223531A1 · 1996 [cited by applicant]
CA 2306024 · 1999 [cited by applicant]
CA 2359375A1 · 2000 [cited by applicant]
CA 2527743 · 2004 [cited by applicant]
CA 2960334A1 · 2016 [cited by applicant]
CL 2021001430A1 · 2021 [cited by applicant]
CN 1199339A · 1998 [cited by applicant]
CN 1250370A · 2000 [cited by applicant]
CN 1257510A · 2000 [cited by applicant]
CN 1376166A · 2002 [cited by applicant]
CN 101133082A · 2008 [cited by applicant]
CN 101663022A · 2010 [cited by applicant]
CN 102579350A · 2012 [cited by applicant]
CN 105963257A · 2016 [cited by applicant]
CN 106999602A · 2017 [cited by applicant]
CN 105777872 · 2019 [cited by applicant]
DE 3546150A1 · 1987 [cited by applicant]
DE 3609555A1 · 1987 [cited by applicant]
DE 3900926A1 · 1989 [cited by applicant]
DE 4208677A1 · 1993 [cited by applicant]
DK PA200101010 · 2001 [cited by applicant]
DK 1412384T3 · 2008 [cited by applicant]
EP 0037043B1 · 1984 [cited by applicant]
EP 195075 · 1988 [cited by applicant]
EP 0299527A1 · 1989 [cited by applicant]
EP 327910 · 1989 [cited by applicant]
EP 359070A2 · 1990 [cited by applicant]
EP 0431679 · 1990 [cited by applicant]
EP 0438767 · 1990 [cited by applicant]
EP 450905A1 · 1991 [cited by applicant]
EP 0452281A1 · 1991 [cited by applicant]
EP 0496141A1 · 1992 [cited by applicant]
EP 498737 · 1992 [cited by applicant]
EP 879610 · 1992 [cited by applicant]
EP 608343 · 1993 [cited by applicant]
EP 0552996A1 · 1993 [cited by applicant]
EP 0554996 · 1993 [cited by applicant]
EP 594349 · 1994 [cited by applicant]
EP 699687 · 1995 [cited by applicant]
EP 0673482 · 1995 [cited by applicant]
EP 699686A2 · 1996 [cited by applicant]
EP 702970 · 1996 [cited by applicant]
EP 0708179A2 · 1996 [cited by applicant]
EP 747390 · 1996 [cited by applicant]
EP 0923159A2 · 1999 [cited by applicant]
EP 0923950A2 · 1999 [cited by applicant]
EP 0926159 · 1999 [cited by applicant]
EP 0937471 · 1999 [cited by applicant]
EP 937476 · 1999 [cited by applicant]
EP 1003581 · 1999 [cited by applicant]
EP 0978565A1 · 2000 [cited by applicant]
EP 1025125A1 · 2000 [cited by applicant]
EP 1329462 · 2001 [cited by applicant]
EP 1424077 · 2002 [cited by applicant]
EP 1250167A1 · 2002 [cited by applicant]
EP 1344533 · 2003 [cited by applicant]
EP 1396499 · 2004 [cited by applicant]
EP 1412384A2 · 2004 [cited by applicant]
EP 722492 · 2005 [cited by applicant]
EP 1570876A2 · 2005 [cited by applicant]
EP 1601396A2 · 2005 [cited by applicant]
EP 1687019A2 · 2006 [cited by applicant]
EP 0944648B1 · 2007 [cited by applicant]
EP 2394656A2 · 2011 [cited by applicant]
EP 3295952A1 · 2018 [cited by applicant]
FR 2583291 · 1986 [cited by applicant]
FR 2767479 · 1999 [cited by applicant]
GB 735443A · 1955 [cited by applicant]
GB 995065A · 1965 [cited by applicant]
GB 1232899A · 1971 [cited by applicant]
GB 2141799A · 1985 [cited by applicant]
HU 213691B · 1997 [cited by applicant]
HU 215007B · 1998 [cited by applicant]
HU 215366B · 1998 [cited by applicant]
HU 215634B · 1999 [cited by applicant]
IT 1222331B · 1990 [cited by applicant]
JP H05337179A · 1993 [cited by applicant]
JP H06296691A · 1994 [cited by applicant]
JP 10101696 · 1998 [cited by applicant]
JP 2000510813 · 2000 [cited by applicant]
JP 2001525371 · 2001 [cited by applicant]
JP 2002501790A · 2002 [cited by applicant]
JP 2002504908 · 2002 [cited by applicant]
JP 2002508332 · 2002 [cited by applicant]
JP 2002524514 · 2002 [cited by applicant]
JP 2002532557 · 2002 [cited by applicant]
JP 2003519195 · 2003 [cited by applicant]
JP 2003519195A · 2003 [cited by applicant]
JP 3503129B2 · 2004 [cited by applicant]
JP 2004518756A · 2004 [cited by applicant]
JP 2015522573A · 2015 [cited by applicant]
KR 20060135661A · 2006 [cited by applicant]
KR 20140018798A · 2014 [cited by applicant]
KR 20170021313A · 2017 [cited by applicant]
PA 200101010 · 2001 [cited by applicant]
RU 2111019 · 1997 [cited by applicant]
RU 2180218 · 2002 [cited by applicant]
TW 267945B · 1996 [cited by applicant]
WO 8706941A1 · 1987 [cited by applicant]