Neurosleeve for closed loop EMG-FES based control of pathological tremors
A tremor suppression device includes a garment wearable on an anatomical region and including electrodes contacting the anatomical region when the garment is worn on the anatomical region, and an electronic controller configured to: detect electromyography (EMG) signals as a function of anatomical location and time using the electrodes; identify tremors as a function of anatomical location and time based on the EMG signals; and apply neuromuscular electrical stimulation (NMES) at one or more anatomical locations as a function of time using the electrodes to suppress the identified tremors.
1. A tremor suppression method comprising:
using a garment worn on an anatomical region of a patient and including an array of electrodes disposed on an inside of the garment and contacting the anatomical region, measuring baseline tremors in the anatomical region; and
performing closed-loop feedback controlled tremor suppression including:
applying a tremor suppression therapy to the patient;
measuring modified tremors in the anatomical region during or after the applying of the tremor suppression therapy to the patient; and
tuning the tremor suppression therapy applied to the patient based on the measured modified tremors while repeating the applying and the measuring of the modified tremors until the measuring of the modified tremors indicates that tremor suppression is achieved.
2. The tremor suppression method of claim 1 , wherein the modified tremors in the anatomical region are measured as a function of time.
3. The tremor suppression method of claim 1 , wherein the applying of the tremor suppression therapy to the patient comprises:
applying an electrical stimulation to the patient by Vagus Nerve Stimulation (VNS) using a nerve stimulation interface.
4. The tremor suppression method of claim 1 , wherein wherein the applying of the tremor suppression therapy to the patient comprises:
applying an electrical stimulation to the patient by Direct Brain Stimulation (DBS) using a nerve stimulation interface.
5. The tremor suppression method of claim 1 , wherein the using of the garment to measure modified tremors in the anatomical region is performed during the applying of the tremor suppression therapy to the patient.
6. The tremor suppression method of claim 1 , wherein the garment is a sleeve and the anatomical region is an arm, a leg, a wrist, an ankle, an arm and a wrist, or a leg and an ankle.
7. The tremor suppression method of claim 1 , wherein the anatomical region is at least one of an arm, a wrist and/or a hand, or a leg, an ankle, and/or a foot.
8. A tremor suppression method comprising:
using a garment worn on an anatomical region of a patient and including an array of electrodes disposed on an inside of the garment and contacting the anatomical region, measuring baseline tremors in the anatomical region; and
performing closed-loop feedback controlled tremor suppression including:
applying an electrical stimulation to the patient by Vagus Nerve Stimulation (VNS) using a nerve stimulation interface;
measuring modified tremors in the anatomical region as a function of time during or after the applying of the electrical stimulation by VNS; and
tuning the electrical stimulation to the patient by VNS based on the modified tremors measured as a function of time while repeating the applying and the measuring of the modified tremors until the measuring of the modified tremors indicates that tremor suppression is achieved.
9. The tremor suppression method of claim 8 , wherein the using of the garment to measure modified tremors in the anatomical region is performed during the electrical stimulation by VNS.
10. The tremor suppression method of claim 8 , wherein the garment is a sleeve and the anatomical region is an arm, a leg, a wrist, an ankle, an arm and a wrist, or a leg and an ankle.
11. The tremor suppression method of claim 8 , wherein the anatomical region is at least one of an arm, a wrist and/or a hand, or a leg, an ankle, and/or a foot.
12. A tremor suppression apparatus comprising:
a tremor suppression therapy device;
a garment configured to be worn on an anatomical region of the patient and including an array of electrodes disposed on an inside of the garment and contacting the anatomical region when the garment is worn on the anatomical region; and
an electronic processor configured to measure baseline tremors in the anatomical region using the electrodes disposed on the inside of the garment, and to perform closed-loop feedback controlled tremor suppression including:
applying tremor suppression therapy to the patient using the tremor suppression therapy device;
during or after the applying of the tremor suppression therapy to the patient, measuring modified tremors in the anatomical region using the electrodes disposed on the inside of the garment; and
tuning the tremor suppression therapy applied to the patient based on the measured modified tremors while repeating the applying and the measuring of the modified tremors until the measuring of the modified tremors indicates that tremor suppression is achieved.
13. The tremor suppression apparatus of claim 12 , wherein the modified tremors in the anatomical region are measured as a function of time.
14. The tremor suppression apparatus of claim 12 , wherein the tremor suppression therapy device comprises a nerve stimulation interface configured to perform Vagus Nerve Stimulation (VNS), and the applying of the tremor suppression therapy to the patient comprises applying an electrical stimulation to the patient by VNS using the nerve stimulation interface.
15. The tremor suppression apparatus of claim 12 , wherein the tremor suppression therapy device comprises a nerve stimulation interface configured to perform Direct Brain Stimulation (DBS), and the applying of the tremor suppression therapy to the patient comprises applying an electrical stimulation to the patient by DBS using the nerve stimulation interface.
16. The tremor suppression apparatus of claim 12 , wherein the modified tremors in the anatomical region are measured during the applying of the tremor suppression therapy to the patient using the tremor suppression therapy device.
17. The tremor suppression apparatus of claim 12 , wherein the garment is a sleeve and the anatomical region is an arm, a leg, a wrist, an ankle, an arm and a wrist, or a leg and an ankle.