Compositions and methods for the treatment of alopecia
Embodiments relate to compositions and methods for the treatment of hair loss, which can include treatment of alopecia, via an application of a composition including an alkalizing agent and/or a sulfotransferase enzyme. The composition can be formulated to be an orally administered composition. In some embodiments, the composition is used to increase the response of minoxidil.
1. A method for improving, increasing, or enhancing hair re-growth of a subject suffering from alopecia, the method comprising:
orally administering a composition comprising an alkalizing agent and a sulfotransferase enzyme to a subject suffering from alopecia, thereby promoting sulfotransferase enzyme expression in an outer root sheath of a hair follicle of the subject.
2. The method of claim 1 ,
further comprising administering the composition further involves administering the composition topologically, via injection, or transdermally; and/or
administering the composition as a drug, a nutritional supplement, or a cosmetic.
3. The method of claim 1 , further comprising:
administering the composition before, during, and/or after administration of minoxidil.
4. The method of claim 1 ,
the composition further comprises minoxidil.
5. The method of claim 1 , wherein:
the alkalizing agent comprises one or more of a bicarbonate, citrate, a loop diuretic, MOPS, BES, TES, HEPES, DIPSO, TAPSO, Acetamidoglycine, POPSO, HEPPSO, HEPPS, Tricine, Tris (tromethamine), Glycinamide, Glycylglycine, Bicine, or TAPS.
6. The method of claim 1 , wherein:
the sulfotransferase enzyme comprises a human sulfotransferase enzyme and/or a non-human sulfotransferase enzyme.
7. The method of claim 1 , wherein:
the sulfotransferase enzyme comprises one or more of a carbohydrate sulfotransferase, a galactose-3-O-sulfotransferase, a heparan sulfate 2-O-sulfotransferase, a heparan sulfate 3-O-sulfotransferase, a heparan sulfate 6-O-sulfotransferase, a N-deacetylase/N-sulfotransferase, a tyrosylprotein sulfotransferase, an uronyl-2-sulfotransferase, an estrone sulfotransferase, a chondroitin 4-sulfotransferase, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1B1, SULT1C2, SULT1C3, SULT1C4, SULT1D1P, SULT1E1, SULT2A1, SULT2B1, SULT4A1, or SULT6B1.
8. The method of claim 1 , wherein:
the composition contains natural levels or extracts of minoxidil sulfotransferase enzymes, natural levels or extracts of phenol sulfotransferase enzymes, and/or natural levels of extracts sulfotransferase enzymes derived from Populus trichocarpa, Populus x canescens, Salix sp., Arabidopsis thaliana , silver poplar ( Populus alba ), Simon's poplar ( Populus simonii ), S. purpurea, P. tremuloides, I. polycarpa, P. nigra, Oryza sativa , Salicaceae family, Poplars ( Populus sp.), Idesia polycarpa , Japanese orange cherry, Potato ( Solanum tuberosum ), Cabbage ( Brassica rapa ), Populus trichocarpa (Black cottonwood), Salix Sp. (Willow tree), Cotton ( Gossypium ), Olea europaea L, Brassica napus, Apium graveolens, Brassica oleracea, Saccharina japonica, Solanum tuberosum , and/or Black cottonwood; and
the natural levels or extracts of minoxidil sulfotransferase enzymes, phenol sulfotransferase enzymes, and/or sulfotransferase enzymes are present in amounts ranging from 1%-100% by weight.
9. The method of claim 1 , wherein:
the sulfotransferase enzyme comprises OeST1.
10. The method of claim 1 , further comprising:
quantifying activity of SULT1A1 in dermal papillae cells and/or dermal sheath of the subject.
11. The method of claim 10 , further comprising:
determining a dosage and/or treatment regimen for the composition based on the quantitative measurement of activity of SULT1A1 in dermal papillae cells and/or dermal sheath of the subject.
12. A method for improving, increasing, or enhancing minoxidil response to a subject suffering from alopecia, the method comprising:
performing the method of claim 1 while the subject is undergoing minoxidil treatment for the alopecia.
13. A method for increasing sulfotransferase enzyme activity in a scalp and/or a liver of a subject suffering from alopecia, the method comprising:
orally administering a composition comprising an alkalizing agent and a sulfotransferase enzyme to a subject suffering from alopecia, thereby promoting sulfotransferase enzyme expression in an outer root sheath of a hair follicle of the subject.