Treatment of cancer with a RAF inhibitor
Provided herein are compositions and methods for the treatment of a cancer. Said compositions comprise a RAF inhibitor. Some embodiments comprise combination therapy featuring the RAF inhibitor with at least one oncology therapeutic agent.
1. A method of treating a cancer in a patient in need thereof, comprising administering to the patient (S)-N-(3-(2-(((R)-1-hydroxypropan-2-yl)amino)- 6-morpholinopyridin-4-yl)-4-methylphenyl)-3-(2,2,2-trifluoroethyl) pyrrolidine-1-carboxamide, or pharmaceutically acceptable salt or solvate thereof, wherein the cancer is characterized as having an oncogenic BRAF alteration, and wherein the cancer is metastatic melanoma.
2. A method of treating a cancer in a patient in need thereof, comprising administering to the patient (S)-N-(3-(2-(((R)-1-hydroxypropan-2-yl) amino)-6-morpholinopyridin-4-yl)-4-methylphenyl)-3-(2,2,2-trifluoroethyl) pyrrolidine-1-carboxamide, or pharmaceutically acceptable salt or solvate thereof, wherein the cancer is characterized as having an oncogenic BRAF alteration, wherein the cancer is non-small cell lung cancer.
3. The method of claim 2 , wherein the non-small cell lung cancer exhibits a BRAF V600 mutation.
4. The method of claim 3 , wherein the BRAF V600 mutation is a V600E or V600K mutation.
5. The method of claim 2 , wherein the non-small cell lung cancer exhibits a Class II BRAF mutation.
6. The method of claim 2 , wherein the non-small cell lung cancer is metastatic.
7. The method of claim 6 , wherein the method is adjuvant therapy following surgical resection.
8. The method of claim 6 , wherein the patient has relapsed after prior therapy.
9. The method of claim 6 , wherein the patient has acquired resistance to prior therapy.
10. The method of claim 6 , wherein the patient is refractory to therapy.
11. The method of claim 1 , wherein the method is adjuvant therapy following surgical resection.
12. The method of claim 1 , wherein the patient has relapsed after prior therapy.
13. The method of claim 1 , wherein the patient has acquired resistance to prior therapy.
14. The method of claim 1 , wherein the patient is refractory to therapy.
15. The method of claim 2 , wherein the method is adjuvant therapy following surgical resection.
16. The method of claim 2 , wherein the patient has relapsed after prior therapy.
17. The method of claim 2 , wherein the patient has acquired resistance to prior therapy.
18. The method of claim 2 , wherein the patient is refractory to therapy.
19. The method of claim 1 , wherein the (S)-N-(3-(2-(((R)-1-hydroxypropan-2-yl) amino)-6-morpholinopyridin-4-yl)-4-methylphenyl)-3-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, or pharmaceutically acceptable salt or solvate thereof, is administered orally.
20. The method of claim 2 , wherein the (S)-N-(3-(2-(((R)-1-hydroxypropan-2-yl)amino)-6-morpholinopyridin-4-yl)-4-methylphenyl)-3-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, or pharmaceutically acceptable salt or solvate thereof, is administered orally.