IP Library Granted Patent US 12,357,734
Granted Patent B2
US 12,357,734 · App. 18/298,617 · Granted Jul 15, 2025

Extracorporeal blood filtering machine and methods

Inventors: Vitaliy Gennad'yevich Epshteyn (Maple Grove, MN); Steven Daniel Sandoval (Eden Prairie, MN); Kalley Francis Berg (Lino Lakes, MN); Franz Willems Ulrich (Minneapolis, MN)
Assignee: NUWELLIS, INC.
A61M1/154A61M1/1601A61M1/36224A61J1/10A61M1/14A61M1/155A61M1/1562A61M1/15632A61M1/1566A61M1/16A61M1/1643A61M1/1694A61M1/34A61M1/3403A61M1/341A61M1/3413A61M1/342A61M1/3424A61M1/3427A61M1/3431A61M1/3434A61M1/3437A61M1/3441A61M1/3444A61M1/3451A61M1/3607A61M1/361A61M1/36225A61M1/362262A61M1/362264A61M1/362266A61M1/3624A61M1/3626A61M1/3627A61M1/3639A61M1/3644A61M1/3663A61M1/3672A61M5/1415A61M5/165A61M5/172A61M60/109A61M60/268A61M2202/0042A61M2205/3331A61M2205/3368A61M2205/3379A61M2205/3393A61M2205/50A61M2205/502A61M2205/505A61M2205/82A61M2205/8206A61M2205/8262A61M2230/005
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Quick Facts
Patent No.
US 12,357,734
App. No.
18/298,617
Granted
Jul 15, 2025
Kind
B2
Abstract

An extracorporeal blood filtering machine can include a blood circuit, an effluent circuit, and a source fluid circuit and can be controlled by a controller. The extracorporeal blood filtering machine can also include access ports for connecting the source fluid circuit to the blood circuit, as well as blood sensors to detect possible issues with the extracorporeal blood filtering machine. The extracorporeal blood filtering machine can include density sensors and flow sensors that enable it to be more accurate and to operate while being transported. The extracorporeal blood filtering machine can further include a user interface and can display fluid inflow/outflow information. A medical fluid container can automatically empty after being filled. An apparatus for supporting a medical fluid container can include a hanger and an attachment member with the apparatus able to adjust to ensure the medical fluid container remains properly oriented directly under a medical fluid container scale.

Claims (83)

1. An extracorporeal blood filtering system comprising:

a blood circuit that includes:

a blood line comprising a blood inlet configured to receive blood from a patient and a blood outlet configured to return the blood to the patient,

a filter fluidly connected to the blood line between the blood inlet and the blood outlet, and

a blood pump configured to pump the blood from the blood inlet to the blood outlet through the filter, the filter configured to remove waste from the blood;

an effluent circuit that includes:

an effluent line fluidly connected to the filter, the effluent line configured to receive the waste from the filter in the form of effluent, and

an effluent pump configured to pump the effluent from the filter through the effluent line to an effluent receptacle;

a controller configured to:

determine a quantity of effluent pumped through the effluent line into the effluent receptacle based on a determined effluent density value, and

output a system control signal based on the quantity of effluent.

2. The extracorporeal blood filtering system of claim 1 , further comprising an effluent density sensor, wherein the controller is configured to receive the determined effluent density value from the effluent density sensor.

3. The extracorporeal blood filtering system of claim 2 , wherein the effluent density sensor is inline with the effluent line.

4. The extracorporeal blood filtering system of claim 2 , wherein the effluent density sensor is offline from the effluent line.

5. The extracorporeal blood filtering system of claim 4 , wherein the controller is configured to receive a user input indicative of the determined effluent density value output by the effluent density sensor.

6. The extracorporeal blood filtering system of claim 4 , wherein the blood circuit, the effluent circuit, and the controller are housed in an extracorporeal blood filtering machine, and the effluent density sensor is separate from the extracorporeal blood filtering machine.

7. The extracorporeal blood filtering system of claim 1 , further comprising a scale configured to measure an effluent weight value of the effluent receptacle, wherein the controller is configured to determine the quantity of effluent based on the determined effluent density value and the effluent weight value.

8. The extracorporeal blood filtering system of claim 1 , further comprising:

a source fluid circuit that includes:

a source fluid line fluidly connected to a source fluid reservoir and to the blood circuit, and

a source fluid pump configured to pump source fluid from the source fluid reservoir through the source fluid line into the blood circuit,

wherein:

the controller is further configured to determine a quantity of source fluid pumped through the source fluid line from the source fluid reservoir based on a determined source fluid density value, and

the system control signal is based on the quantity of source fluid.

9. The extracorporeal blood filtering system of claim 8 , further comprising a source fluid density sensor, wherein the controller is configured to receive the determined source fluid density value from the source fluid density sensor.

10. The extracorporeal blood filtering system of claim 9 , wherein the source fluid density sensor is inline with the source fluid line.

11. The extracorporeal blood filtering system of claim 9 , wherein the source fluid density sensor is offline from the source fluid line.

12. The extracorporeal blood filtering system of claim 11 , wherein the controller is configured to receive a user input indicative of the determined source fluid density value output by the source fluid density sensor.

13. The extracorporeal blood filtering system of claim 11 , wherein the blood circuit, the effluent circuit, and the controller are housed in an extracorporeal blood filtering machine, and the source fluid density sensor is separate from the extracorporeal blood filtering machine.

14. The extracorporeal blood filtering system of claim 8 , further comprising a first scale configured to measure an effluent weight value of the effluent receptacle, and a second scale configured to measure a source fluid weight value of the source fluid reservoir, wherein the controller is configured to:

determine the quantity of effluent based on the determined effluent density value and the effluent weight value, and

determine the quantity of source fluid based on the determined source fluid density value and the source fluid weight value.

15. The extracorporeal blood filtering system of claim 8 , further comprising a source fluid scale, wherein:

the source fluid pump is configured to pump (a) priming fluid from a priming fluid reservoir through the source fluid line during a priming operation and (b) source fluid from the source fluid reservoir through the source fluid line into the blood circuit during standard operation,

the source fluid scale is configured to measure (a) a priming fluid weight value of the priming fluid reservoir during the priming operation and (b) a source fluid weight value of the source fluid reservoir during standard operation,

the controller is configured to:

determine a source fluid pump rate during the priming operation based on the priming fluid weight value and a known priming fluid density value, and

determine the determined source fluid density value during standard operation based on the source fluid weight value and the source fluid pump rate.

16. A method comprising:

providing an extracorporeal blood filtering system that includes:

a blood circuit comprising:

a blood line comprising a blood inlet and a blood outlet,

a filter fluidly connected to the blood line between the blood inlet and the blood outlet, and

a blood pump;

an effluent circuit that includes:

an effluent line fluidly connected to the filter, and

an effluent pump; and

a source fluid circuit that includes:

a source fluid line fluidly connected to a source fluid reservoir and to the blood circuit, and

a source fluid pump;

operating the blood pump to pump blood received from a patient at the blood inlet through the filter and back to the patient at the blood outlet, the filter removing waste from the blood and providing the waste to the effluent line in the form of effluent;

operating the effluent pump to pump the effluent from the filter through the effluent line into an effluent receptacle;

operating the source fluid pump to pump source fluid from the source fluid reservoir through the source fluid line into the blood circuit;

determining an effluent density value of the effluent and a source fluid density value of the source fluid;

determining a quantity of effluent pumped through the effluent line into the effluent receptacle based on the effluent density value;

determining a quantity of source fluid pumped through the source fluid line from the source fluid reservoir based on the source fluid density value; and

outputting a system control signal based on the quantity of effluent and the quantity of source fluid.

17. The method of claim 16 , wherein:

the extracorporeal blood filtering system further includes an effluent density sensor and a source fluid density sensor,

determining the effluent density value of the effluent comprises measuring the effluent density value with the effluent density sensor, and

determining the source fluid density value of the source fluid comprises measuring the source fluid density value with the source fluid density sensor.

18. The method of claim 17 , wherein:

the effluent density sensor is inline with the effluent line, and

the source fluid density sensor is inline with the source fluid line.

19. The method of claim 17 , wherein:

the effluent density sensor is offline from the effluent line, and

the source fluid density sensor is offline from the source fluid line.

20. The method of claim 19 , wherein:

determining the effluent density value of the effluent further comprises receiving a first user input indicative of the effluent density value output by the effluent density sensor, and

determining the source fluid density value of the source fluid further comprises receiving a second user input indicative of the source fluid density value output by the source fluid density sensor.

21. The method of claim 16 , wherein:

the extracorporeal blood filtering system further comprises an effluent scale and a source fluid scale,

the method further comprises:

measuring an effluent weight value of the effluent receptacle with the effluent scale, measuring a source fluid weight value of the source fluid reservoir with the source fluid scale,

determining the quantity of effluent pumped through the effluent line into the effluent receptacle is based on the effluent density value and the effluent weight value, and

determining the quantity of source fluid pumped through the source fluid line from the source fluid reservoir is based on the source fluid density value and the source fluid weight value.

22. The method of claim 16 , wherein:

the extracorporeal blood filtering system further comprises a source fluid scale, the method further comprises:

operating the source fluid pump to pump a priming fluid from a priming fluid reservoir through the source fluid line during a priming operation,

operating the source fluid pump to pump source fluid from the source fluid reservoir through the source fluid line into the blood circuit during standard operation,

using the source fluid scale to measure (a) a priming fluid weight value of the priming fluid reservoir during the priming operation and (b) a source fluid weight value of the source fluid reservoir during standard operation,

determining a source fluid pump rate during the priming operation based on the priming fluid weight value and a known priming fluid density value, and

determining the source fluid density value during standard operation based on the source fluid weight value and the source fluid pump rate.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 6, 2023
From: EPSHTEYN, VITALIY GENNAD'YEVICH; SANDOVAL, STEVEN DANIEL; BERG, KALLEY FRANCIS; ULRICH, FRANZ WILLEMS
To: NUWELLIS, INC.
Reel/Frame 063863/0857 →
Continuity (2)
Continuation 18171612 · Feb 20, 2023
Related Publication 20240277929A1 · Aug 22, 2024
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